Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Brittany E. Yee ◽  
Phillip Richards ◽  
Jennifer Y. Sui ◽  
Amanda Fleming Marsch
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Treatment ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ling-Jun Wang ◽  
Ming-Qing Wang ◽  
Rong Hu ◽  
Yi Yang ◽  
Yu-Sheng Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Subgroup Analysis ◽  
Zinc Supplementation ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Maintenance Hemodialysis ◽  
Randomized Controlled ◽  
Zinc Levels ◽  
Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

scholarly journals Serum Zinc Levels and the Effect of Oral Zinc in Acne Vulgaris

2020 ◽  
Vol 7 (47) ◽  
pp. 2777-2782
Author(s):  
Mohan Rao Munnaluri ◽  
Sravan Chittla ◽  
Nihal Perumalla
Keyword(s):  
Zinc Sulphate ◽  
Social Issues ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Normal Serum ◽  
Female Ratio ◽  
Chronic Inflammatory Condition ◽  
Different Types ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND Acne vulgaris is a chronic inflammatory condition of the pilosebaceous unit which occurs in adolescent age groups. Physical and psychological scars can create social issues in the family, school and workplace. The disorder is multifactorial. There are plenty of recovery choices but are not satisfactory. We wanted to investigate the serum zinc levels and the therapeutic utility of oral zinc supplementation in acne vulgaris patients. METHODS This is a prospective study conducted over a period of one and a half years among one hundred acne patients who reported to the outpatient clinic of the Department of Dermatology, Venereology and Leprology with untreated patients of acne vulgaris. RESULTS Males were 65 % and females were 35 % with male : female ratio of 6.5 : 3.5. Most of the patients were students occupying 71 % of the study. Family history was observed in 46 % of patients, either in the siblings or in the parents. Premenstrual flare-up of acne lesions was noted in 71.42 % of female patients indicating a pivotal role of hormones in the pathogenesis of acne. Aggravation of lesions in summer was noted in 45 % of patients. Aggravation of acne lesions with different types of diet like non-vegetarian food, oily food and chocolates was noticed in 69 % of the study. History of usage of different types of cosmetics available in the market was noted in 76 % of the patients. In the present study, 62 % had lower than normal serum zinc levels and 38 % had normal serum zinc levels. Thus, serum zinc levels were found to be lower in both male and female acne patients in the majority (62 %) of the study patients and also normal healthy controls. The fasting serum zinc levels in the 62 patients before and after oral zinc sulphate were estimated after completion of 3 months treatment. Normal serum zinc levels were observed in all 62 patients treated. CONCLUSIONS Oral zinc sulphate is an effective, safe and economic remedy in the treatment of acne vulgaris. The extra advantage with oral zinc sulphate is that it is devoid of many adverse reactions commonly seen after prolonged use of systemic antibiotics. KEYWORDS Oral Zinc Sulphate, Acne Vulgaris

scholarly journals Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis

2018 ◽  
Vol 46 (12) ◽  
pp. 4898-4906 ◽  
Author(s):  
Yueying Xie ◽  
Junjie Wang ◽  
Xiaoya Zhao ◽  
Xuli Zhou ◽  
Xiaohui Nie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Cervical Cancer Risk ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

2021 ◽  
Vol 25 (2) ◽  
pp. 407-415
Author(s):  
Sadeq A. Al-Maweri ◽  
Esam Halboub ◽  
Hesham Mohammed Al-Sharani ◽  
Anas Shamala ◽  
Ahlam Al-Kamel ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Trial Sequential Analysis ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Correlation between the Severity and Type of Acne Lesions with Serum Zinc Levels in Patients with Acne Vulgaris

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Majid Rostami Mogaddam ◽  
Nastaran Safavi Ardabili ◽  
Nasrollah Maleki ◽  
Maedeh Soflaee
Keyword(s):  
Acne Vulgaris ◽  
Serum Zinc ◽  
Atomic Absorption Spectrophotometry ◽  
Zinc Level ◽  
Healthy Controls ◽  
Serum Zinc Level ◽  
Absorption Spectrophotometry ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Some studies have reported an association between serum zinc levels and acne vulgaris. We aimed to evaluate the serum zinc level in patients with acne vulgaris and compare it with healthy controls. One hundred patients with acne vulgaris and 100 healthy controls were referred to our clinic. Acne severity was classified according to Global Acne Grading System (GAGS). Atomic absorption spectrophotometry was used to measure serum zinc levels. Mean serum level of zinc in acne patients and controls was 81.31 ± 17.63 μg/dl and 82.63 ± 17.49 μg/dl, respectively. Although the mean serum zinc level was lower in acne group, it was not statistically significant (P=0.598). There was a correlation between serum zinc levels with severity and type of acne lesions. The results of our study suggest that zinc levels may be related to the severity and type of acne lesions in patients with acne vulgaris. Relative decrease of serum zinc level in acne patients suggests a role for zinc in the pathogenesis of acne vulgaris.

scholarly journals EVALUATION OF SERUM ZINC LEVEL

2018 ◽  
Vol 25 (02) ◽  
pp. 307-312
Author(s):  
Thiga Mohammed Mohammed Osman Alhassan ◽  
Abdelmula Mohamed Abdalla ◽  
Eshtiag Mohammed Mohammed Osman Alhassan ◽  
Suhair Abdelrahman Ahmed
Keyword(s):  
Reference Group ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Level ◽  
Chronic Inflammatory Disease ◽  
Acrodermatitis Enteropathica ◽  
Serum Zinc Level ◽  
Severe Acne ◽  
Zinc Levels ◽  
Serum Zinc Levels

Back ground: Acne vulgaris is a common chronic inflammatory disease ofthe skin. Zinc is a trace element, exists in high amounts within the skin and especially theepidermis. Its importance for human metabolism has been noted by the dramatic improvementof acrodermatitis enteropathica following zinc supplementation. Objectives: To evaluate theserum zinc level among patients with acne vulgaris, and to correlate age, grade and durationof acne vulgaris with serum zinc level. Study Design: Case- control hospital base study.Setting: Khartoum state at Khartoum Dermatology & Venerology Hospital. Period: February toSeptember 2017. Materials Methods: 100 samples were collected from patients attending toKhartoum Dermatology & Venerology hospital suffering from acne vulgaris. Acne severity wasclassified according to Global Acne Grading System (GAGS). In addition to other 100 samplescollected from healthy individuals (students and nurse) sex and age matched as control. Thelevels of serum zinc was measured in each group by atomic absorption spectroscopy. Results:The study showed significant decrease in the zinc concentrations in acne vulgaris patientswhen compared with the reference group (0.207±0.04 mg/l versus 0.788 ± 0.14 mg/l) (p=0.000). The study observed decreased serum zinc level with advancedgrade of acne; mild47 patients (47%) (0.247 ± 0.05), moderate 33 (33%) (0.1925 ± 0.04) and severe in 20 (20%)(0.180 ± 0.03), based on the anova test analysis mean serum zinc levels were significantlylower in patients with mild to moderate and to severe acne vulgaris when compared betweenacne vulgairs grades and with reference group(p ≤ 0.001, p ≤ 0.01, p ≤ 0.05 respectively).The present study showed no correlation between zinc level (mg/l) and age in patient with acnevulgaris (years) (r=0.032, P =0.827). On the other hand significant correlation was recordedbetween serum zinc level (mg/l) and duration of the acne vulgaris in the study group (r=-0.311,p = 0.028). Conclusion: Study revealed that serum zinc levels is significantly decreased inpatients with acne vulgaris, and prescribing zinc supplement treatments help increasing thesuccess rate of acne treatment.

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