Thickness of actinic elastosis a surrogate marker of chronic UV‐damage : A post mortem analysis of 41 cases

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Margareta J. Riegler ◽  
Sebastian Mannweiler ◽  
Angelika Sturm ◽  
Augustin Donnerer ◽  
Mario Darok ◽  
...  
Keyword(s):  
Surrogate Marker ◽  
Post Mortem ◽  
Uv Damage ◽  
Actinic Elastosis

Ante Mortem Cerebrospinal Fluid Levels of Calsyntenin-1 and Neurexin-2a Reflect Post-Mortem TDP-43 Pathology in a Pathological Cohort of Frontotemporal Lobar Degeneration

2021 ◽  
Author(s):  
Alba Cervantes-González ◽  
David J Irwin ◽  
Daniel Alcolea ◽  
Corey T McMillan ◽  
Alice Chen-Plotkin ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Frontotemporal Lobar Degeneration ◽  
Neurofibrillary Tangle ◽  
Surrogate Marker ◽  
Quantitative Measure ◽  
Synaptic Proteins ◽  
Analysis Of Covariance ◽  
Early Event ◽  
Post Mortem ◽  
Csf Levels

Abstract Background. Frontotemporal dementia (FTD) clinical diagnosis is challenged by the variable correspondence between the clinical syndrome and underlying neuropathological changes, the phenotypic overlap with Alzheimer's disease (AD) and the lack of pathophysiologic diagnostic biomarkers. As synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD), a surrogate marker of synapse loss could be used to monitor early pathologic changes. The aim of this study was to evaluate the relationship of antemortem cerebrospinal fluid (CSF) levels of 9 synaptic proteins with postmortem global tau and TDP-43 burden in a neuropathological FTLD cohort. Methods. We included patients with a neuropathological confirmation of FTLD-Tau (n=24, mean age-at-CSF 67 years+/-11), FTLD-TDP (n=25, 66 years+/-9) or AD (n=25, 73 years+/-6) as well as cognitively normal controls (n=35, 69 years+/-7) from the Penn FTD Center and ADRC. A subset of 39 FTLD patients presented without AD comorbidity (neurofibrillary tangle score of B0/B1 according to the NIA-AA classification) and 18 AD patients presented without TDP-43 comorbidity. We quantified the synaptic panel in antemortem CSF by targeted mass spectrometry using isotopically-labeled peptides as internal standards. We used a semi-quantitative measure of tau and TDP-43 inclusions to quantify pathological burden across 16 brain regions. Statistical methods included Spearman rank correlations, one-way analysis of covariance (controlling for sex and age-at-CSF), linear regression (controlling for age-at-death) and receiver-operating characteristic curves. Result. CSF calsyntenin-1 and neurexin-2a were correlated in all patient groups (rs=.55 to .88). In FTLD-TDP, we observed low antemortem CSF levels of calsyntenin-1 and neurexin-2a compared to AD (.72-fold, p=.001, .77-fold, p=.04, respectively) and controls (.80-fold, p=.02, .78-fold, p=.02, respectively), which were inversely associated with post-mortem global TDP-43 burden (regression r2=.36, p=.04 and r2=.35, p=.04, respectively). Neurexin-2a showed 75.0% (95% CI 60-88) accuracy to discriminate FTLD-TDP from controls. Calsyntenin-1 showed 75.1% (95% CI 62-87) accuracy to discriminate FTLD-TDP from AD. None of the synaptic proteins were altered in FTLD-Tau compared to controls (0.79 to 1.12-fold, p>.12) or associated with post-mortem global tau burden (r2=.12, p=.36). Comorbidity had a limited effect on these findings. Conclusion. CSF calsyntenin-1 and neurexin-2a have potential as objective measures of TDP-43-mediated degeneration in FTLD.

Ultrastructural investigation of an adenoma of the pituitary post mortem

1987 ◽  
Vol 45 ◽  
pp. 622-623
Author(s):  
Shirley Siew ◽  
W. C. deMendonca
Keyword(s):  
Deleterious Effect ◽  
Anterior Lobe ◽  
Definitive Diagnosis ◽  
Pars Intermedia ◽  
Post Mortem ◽  
Close Apposition ◽  
Autopsy Material ◽  
Progressive Loss ◽  
Transmission Electron ◽  
Means Of Transmission

The deleterious effect of post mortem degeneration results in a progressive loss of ultrastructural detail. This had led to reluctance (if not refusal) to examine autopsy material by means of transmission electron microscopy. Nevertheless, Johannesen has drawn attention to the fact that a sufficient amount of significant features may be preserved in order to enable the establishment of a definitive diagnosis, even on “graveyard” tissue.Routine histopathology of the autopsy organs of a woman of 78 showed the presence of a well circumscribed adenoma in the anterior lobe of the pituitary. The lesion came into close apposition to the pars intermedia. Its architecture was more compact and less vascular than that of the anterior lobe. However, there was some grouping of the cells in relation to blood vessels. The cells tended to be smaller, with a higher nucleocytoplasmic ratio. The cytoplasm showed a paucity of granules. In some of the cells, it was eosinophilic.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem

Aneurysms in the history of medicine

VASA ◽  
2002 ◽  
Vol 31 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Bollinger ◽  
Rüttimann
Keyword(s):  
History Of Medicine ◽  
Albert Einstein ◽  
Thomas Mann ◽  
Post Mortem ◽  
John Hunter ◽  
History Of

Die Geschichte des sackförmigen oder fusiformen Aneurysmas reicht in die Zeit der alten Ägypter, Byzantiner und Griechen zurück. Vesal 1557 und Harvey 1628 führten den Begriff in die moderne Medizin ein, indem sie bei je einem Patienten einen pulsierenden Tumor intra vitam feststellten und post mortem verifizierten. Weitere Eckpfeiler bildeten die Monographien von Lancisi und Scarpa im 18. bzw. beginnenden 19. Jahrhundert. Die erste wirksame Therapie bestand in der Kompression des Aneurysmasacks von außen, die zweite in der Arterienligatur, der John Hunter 1785 zum Durchbruch verhalf. Endoaneurysmoraphie (Matas) und Umhüllung mit Folien wurden breit angewendet, bevor Ultraschalldiagnostik und Bypass-Chirurgie Routineverfahren wurden und die Prognose dramatisch verbesserten. Die diagnostischen und therapeutischen Probleme in der Mitte des 20. Jahrhunderts werden anhand von zwei prominenten Patienten dargestellt, Albert Einstein und Thomas Mann, die beide im Jahr 1955 an einer Aneurysmaruptur verstarben.

Post-Mortem-Versorgung

NOVAcura ◽  
2020 ◽  
Vol 51 (7) ◽  
pp. 1-60
Keyword(s):  
Post Mortem

Findings in post mortem computed tomography (PMCT) after cardiac surgery of the adult

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
B Vogel ◽  
H Gulbins ◽  
H Reichenspurner ◽  
A Heinemann ◽  
H Vogel
Keyword(s):  
Computed Tomography ◽  
Cardiac Surgery ◽  
Post Mortem
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