Pain reduction by dehydrated human amnion/chorion membrane allograft in nondiabetic leg ulcers might be an early indicator of good response: A case series

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Simon M. Mueller ◽  
Alexander A. Navarini ◽  
Peter Itin ◽  
Simon Schwegler ◽  
Severin Laeuchli ◽  
...  
Keyword(s):  
Case Series ◽  
Pain Reduction ◽  
Leg Ulcers ◽  
Human Amnion ◽  
Early Indicator

Dehydrated human amnion/chorion tissue in difficult–to-heal DFUs: a case series

2015 ◽  
Vol 24 (3) ◽  
pp. 104-111 ◽  
Author(s):  
H. Penny ◽  
M. Rifkah ◽  
A. Weaver ◽  
P. Zaki ◽  
A. Young ◽  
...  
Keyword(s):  
Case Series ◽  
Human Amnion

Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series

Vascular ◽  
2014 ◽  
Vol 23 (6) ◽  
pp. 580-585 ◽  
Author(s):  
Seyhan Yilmaz ◽  
Eray Aksoy ◽  
Suat Doganci ◽  
Adnan Yalcinkaya ◽  
Adem I Diken ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Leg Ulcers ◽  
Wound Surface ◽  
Wound Area ◽  
Venous Leg Ulcers ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Prospective Case Series ◽  
Complete Wound Healing

StudyWe report our results on a case series of 19 patients receiving platelet-rich plasma application in treatment of patients with chronic unhealing venous leg ulcers.Material and methodsThere were 16 males and three females with a mean age of 38.55 ± 16.46 years. Planimetric size measurements were performed and pain was tested throughout the treatment period. Follow-up was made in seven-day periods. Patients received 5 ml of platelet-rich plasma for each 5 cm2of the wound surface with half of the amount being injected 1–2 mm deep into the wound and the wound surface was covered with the remaining half.ResultsComplete wound healing occurred in 18 of 19 patients (94.7%) within a mean of 4.82 ± 2.16 week. There were significant reductions in wound area among all consecutive measurements except for first week. A significant reduction in wound volume was apparent even in first week and sustained among consecutive measurements.ConclusionPlatelet-rich plasma seems effective in terms of promoting healing of venous leg ulcers. Improvement in wound depth was slightly more prominent than that in wound area, indicating a potential role of platelet-rich plasma especially in deep venous ulcers.

Use of Porcine-Derived Dermal Substitutes for Treatment of Nonhealing Vascular Leg Ulcers: A Case Series

2020 ◽  
pp. 153473462094556
Author(s):  
Marianna Sallustro ◽  
Raffaele Polichetti ◽  
Anna Florio
Keyword(s):  
Therapeutic Option ◽  
Graft Loss ◽  
Case Series ◽  
Skin Lesions ◽  
Dermal Substitute ◽  
Leg Ulcers ◽  
Major Health Problem ◽  
Dermal Substitutes ◽  
Effective Therapeutic Option ◽  
Wound Bed Preparation

Nonhealing leg ulcers are a major health problem worldwide with a high economic burden since they require human and material resources. Moreover, nonhealing ulcers are a major nontraumatic cause of lower limb amputations. Dermal substitutes have emerged as an effective therapeutic option for treatment of skin lesions, but data on leg ulcers are scarce. We evaluated safety and efficacy of a porcine-derived dermal substitute in the treatment of chronic vascular leg ulcers. Records of patients with nonhealing ulcers seen at our unit from 2018 to 2019 were retrospectively reviewed. Wound etiology, wound area, and complications were evaluated. Each patient received one application of porcine-derived dermal substitute and was followed-up. Six patients (5 females and 1 male) with a mean age of 61.3 (52-81) years presented with nonhealing leg ulcers. After surgical debridement and wound bed preparation, porcine-derived dermal substitute was applied onto the ulcer. Granulation was satisfactory within 10 days. All wounds healed after an average time of 14 weeks. Graft take was good, and no graft loss, rejection, or associated infection were observed. In conclusion, the data presented indicate that dermal substitutes are safe and effective for treatment of chronic nonhealing vascular leg ulcers.

Poster 111: Effect of PTH 1-84 on the Increase in BMD and Pain Reduction of Patients With Osteoporotic Vertebral Fractures. A Case Series

PM&R ◽  
2010 ◽  
Vol 2 ◽  
pp. S54-S54
Author(s):  
Alba Gomez-Garrido ◽  
Silvia Caño ◽  
Carme Garcia-Ameijeiras ◽  
Ana Maria Leon ◽  
Mauricio Tovar-Felice
Keyword(s):  
Vertebral Fractures ◽  
Case Series ◽  
Pain Reduction ◽  
Osteoporotic Vertebral Fractures

scholarly journals Intrapelvic Obturator Internus Muscle Injections: A Novel Fluoroscopic Technique

2015 ◽  
Vol 2;18 (2;3) ◽  
pp. E237-E243
Author(s):  
Assia Valovska
Keyword(s):  
Dimensional Space ◽  
Symptomatic Relief ◽  
Case Series ◽  
Pain Reduction ◽  
Pain Scale ◽  
Pelvic Cavity ◽  
Obturator Internus ◽  
Complex Anatomy ◽  
Scale Scores ◽  
Obturator Internus Muscle

The obturator internus (OI) muscle is important in adult chronic noninfectious pelvic, perineal, gluteal, and retrotrochanteric pain syndromes. Evaluation and management of these patients’ pain can be challenging because of the complex anatomy of this region, broad differential diagnosis, and lack of specific physical examination findings. Consequently, several clinicians have advocated the use of image guided injections to assist in the accurate diagnosis of OI-related symptoms and provide symptomatic relief to affected patients. We present 2 case series describing a novel fluoroscopically guided contrast controlled transpectineal approach to intrapelvic OI injections. Unlike prior fluoroscopically guided OI injection techniques, the approach described in the present 2 cases utilized multiple standard pelvic views, thus facilitating optimal needle positioning in three-dimensional space. This technique utilized standard fluoroscopic pelvic views to accurately measure needle depth within the pelvic cavity permitting the bulk of the OI to be injected in a controlled and safe fashion. The first patient underwent a left intrapelvic OI muscle injection with bupivacaine 0.25% and 40 mg methylprednisolone. The average pre- and postprocedural visual analog pain scale scores were 5 out of 10 and 2 out of 10, respectively, with a self-reported 75% pain reduction. The second patient underwent a right intrapelvic OI muscle injection with bupivacaine 0.25% and 40 mg methylprednisolone. The average pre- and postprocedural visual analog scale scores were 8 out of 10 and 1 out of 10, respectively, with a self-reported 90% pain reduction. Larger scale studies should be undertaken to evaluate the therapeutic efficacy and generalized accuracy of this technique. Key words: Obturator internus muscle, pelvic, perineal, gluteal, retrotrochanteric pain, fluoroscopic, transpectineal

Efficacy of Mobiderm® Bandage in Compression Therapy for Venous Ulcers: A Prospective Case Series

2021 ◽  
pp. 153473462110582
Author(s):  
Harikrishna K.R. Nair ◽  
Xian Lew ◽  
Kong Yen Liew ◽  
Siti Aishah Kamis ◽  
Nik Muhamad Hakimi Nik Kub ◽  
...  
Keyword(s):  
Case Series ◽  
Compression Therapy ◽  
High Morbidity ◽  
Leg Ulcers ◽  
Calf Circumference ◽  
Mean Values ◽  
Venous Leg Ulcers ◽  
Venous Ulcers ◽  
Wound Size ◽  
Prospective Case Series

Background: Venous leg ulcers severely affect patients’ quality of life due to its high morbidity and recurrent nature. Currently, compression therapy is the first-line treatment for venous leg ulcers. Aim: This study sought to evaluate the efficacy of the Mobiderm® technology developed by Thuasne in a prospective case series of venous leg ulcers. Methods: Nine patients ( N  =  9) with venous leg ulcers were enrolled into this case series. Mobiderm® bandage was applied on to the affected limbs of the patients in the multi-component bandages system. The bandages were changed as frequent as the patients had their wound dressing for their standard treatment in a 12-week duration. Wound size and calf circumference were measured at week 0 and week 12. Paired sample t-test was used to compare the mean values of wound size and calf circumference pre- and post-treatment. Results: Reductions in wound size and calf circumference were observed in all nine patients (100%). Five patients were evaluable at week 12. The wound sizes significantly reduced by 27.2% to 53.2% ( p  =  0.02), and the calf circumferences significantly reduced by 3.2% to 26.0% ( p  =  0.02) after 12 weeks ( N  =  5). Safety was unremarkable, with no occurrence of treatment-emergent-related adverse event. Conclusion: Mobiderm® bandage was reported to be effective in promoting wound healing and reducing swelling, suggesting it to be integrated in the compression therapy for the management of venous leg ulcers.

The Difficult Venous Ulcer: Case Series of 177 Ulcers Referred for Vascular Surgical Opinion following Failure of Conservative Management

Angiology ◽  
2009 ◽  
Vol 60 (4) ◽  
pp. 492-495 ◽  
Author(s):  
S. K. Neequaye ◽  
A. D. Douglas ◽  
D. Hofman ◽  
M. Wolz ◽  
R. Sharma ◽  
...  
Keyword(s):  
Case Series ◽  
Venous Ulcer ◽  
Service Planning ◽  
Leg Ulcers ◽  
Surgical Service ◽  
Ulcer Case ◽  
Compression Bandaging ◽  
Dermatology Clinic ◽  
Venous Surgery

Venous leg ulcers are common, chronic, debilitating, and expensive. Evidence supports use of compression bandaging, with superficial venous surgery in selected cases, but these interventions frequently fail to achieve healing. We describe a series of 152 consecutive referrals from a nurse-led specialist dermatology clinic to a vascular surgical service; a group posing particularly challenging problems. This observational study, with median follow-up of 18 months, describes outcomes in a number of important clinically identifiable subgroups. Its findings may assist service planning and discussion of the surgical role within multidisciplinary ulcer management.

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