Successful therapy of recurrent toxic epidermal necrolysis using total plasma exchange, continuous venovenous hemodiafiltration, and intravenous immunoglobulin—Case report

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Andrzej Krajewski ◽  
Maciej J. Mazurek ◽  
Elżbieta Młyńska‐Krajewska
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Total Plasma ◽  
Successful Therapy ◽  
Continuous Venovenous Hemodiafiltration ◽  
Total Plasma Exchange

Plasmapheresis for the Treatment of Acute Pancreatitis due to Severe Hypertriglyceridemia

2020 ◽  
pp. 1-3
Author(s):  
Juan Carlos Ruiz-Rodríguez ◽  
Luis Silvestre Chiscano-Camón ◽  
Clara Palmada ◽  
Verónica Pons ◽  
Ricard Ferrer
Keyword(s):  
Acute Pancreatitis ◽  
Plasma Exchange ◽  
Treatment Options ◽  
Total Plasma ◽  
Severe Hypertriglyceridemia ◽  
Total Plasma Exchange

Severe hypertriglyceridemia (HTG) is associated with acute pancreatitis (AP). Treatment options include total plasma exchange (TPE). We report a case of AP due to severe HTG treated with TPE.

scholarly journals Total Plasma Exchange in Hypertriglyceridemia-Induced Pancreatitis: Case Report and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Harleen Dehal ◽  
Michael Adashek
Keyword(s):  
Plasma Exchange ◽  
Treatment Options ◽  
Clinical Status ◽  
Clinical Situation ◽  
Dramatic Improvement ◽  
Total Plasma ◽  
Rapid Fall ◽  
The Many ◽  
Total Plasma Exchange

Objective. To emphasize the role of apheresis in management of pancreatitis. Methods. The clinical course of a patient admitted for hypertriglyceridemia-induced pancreatitis (HTGP) complicated by multiorgan dysfunction is described, who demonstrated dramatic improvement in his clinical status after total plasma exchange (TPE). In addition, the current guidelines for TPE and the alternative treatment options for HTGP are also presented. Results. A patient presenting with pancreatitis associated with severe systemic inflammatory response was admitted to our hospital with an initial triglyceride level of 1181 mg/dL. Given the patient’s worsening clinical condition, he was started on TPE with a rapid fall in his serum TG levels, in turn leading to early clinical recovery. Conclusion. Though various therapeutic options for the treatment of HTGP are described in literature, there are no set guidelines available to tackle this difficult clinical situation. TPE, albeit not very well known in this context, is one of the many therapies available. Though it leads to a rapid, precipitous fall in the TG levels and early symptom resolution, the data about the long-term morbidity as well as the effectiveness of this therapy is still lacking.

scholarly journals Toxic epidermal necrolysis in an 8-year-old girl successfully treated with cyclosporin A, intravenous immunoglobulin and plasma exchange

2018 ◽  
Vol 35 (2) ◽  
pp. 217-221 ◽  
Author(s):  
Marzena Zielińska ◽  
Łukasz Matusiak ◽  
Waldemar Gołębiowski ◽  
Katarzyna Swiątek ◽  
Iwona Chlebicka ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Toxic Epidermal Necrolysis ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin

scholarly journals Sepsis Mimicking TTP-Case Report and Review of Literature

2020 ◽  
pp. 1-2
Author(s):  
Vijay Raju Krupesh ◽  
◽  
Biswabikash Mohanty ◽  
Srinivas B J ◽  
Sachin Jadhav ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Disease Stage ◽  
Total Leucocyte Count ◽  
Adamts13 Activity ◽  
Total Plasma ◽  
Thrombocytopenic Purpura ◽  
Clinical Dilemma ◽  
Total Plasma Exchange ◽  
Multifocal Disease

Here we report a case of Sepsis mimicking as thrombotic thrombocytopenic purpura in a cancer patient with Urothelioma. A 61-year-old man with High grade Urothelial Carcinoma of left renal pelvis (Multifocal disease) Stage-4 presented with Fever on and off since 1 week and shortness of breath at rest since 2 days and hematuria since 1 day.Later in the course, he developed thrombocytopenia followed by MAHA (Micro Angiopathic haemolytic Anaemia), and other lab abnormalities .Thrombotic thrombocytopenic purpura (TTP) was suspected, and total plasma exchange was considered. Since serum procalcitonin,Total leucocyte count was very high and also had elevated prothrombin time, ADAMTS13(a disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13) was sent for confirmation showed that ADAMTS13 activity of more than 10% for which plasmapheresis was delayed , later patient was treated for sepsis , but patient did not respond and succumbed . This case shows that Sepsis can mimic TTP making diagnosis and treatment extremely difficult. In this type of clinical dilemma to do total plasma exchange (TPE) which is the main modality of treatment for TTP ADAMTS13 activity helps us to prioritise treatment

scholarly journals Role of Plasma Exchange in a Steroid- and IVIG-Refractory Patient with Acute Disseminated Encephalomyelitis: A Case Report

2020 ◽  
Vol 47 (5) ◽  
pp. 420-423 ◽  
Author(s):  
Parmatma Prasad Tripathi ◽  
Rekha Hans ◽  
Ratti Ram Sharma ◽  
Divjot Singh Lamba ◽  
Preeti Paul ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Steroid Therapy ◽  
Neurological Deficit ◽  
Demyelinating Disease ◽  
Acute Disseminated Encephalomyelitis ◽  
Complete Loss ◽  
High Dose

Background: Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease usually affecting children and is treated with high-dose steroid therapy. Case Report: An 8-year boy presented with limbs weakness and complete loss of vision and was resistant to steroid therapy. He was further treated with plasma exchange and showed full recovery from the neurological deficit. Conclusion: Therapeutic plasma exchange appears to be effective in ADEM patients in reversing the neuropathological process especially refractory to steroids and intravenous immunoglobulin.

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