Infective endocarditis in two patients with pemphigus vulgaris under multiagent immunosuppressive drug therapy: A rare entity to remember in the differential diagnosis of fever of unknown origin

2019 ◽  
Vol 32 (3) ◽  
Author(s):  
Rıfkiye Küçükoğlu ◽  
Sıla Kılıç ◽  
Gizem Pınar Sun
Keyword(s):  
Differential Diagnosis ◽  
Drug Therapy ◽  
Infective Endocarditis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pemphigus Vulgaris ◽  
Immunosuppressive Drug ◽  
Rare Entity ◽  
Immunosuppressive Drug Therapy

scholarly journals Large vessel vasculitis secondary to granulocyte-colony stimulating factor

VASA ◽  
2020 ◽  
Vol 49 (6) ◽  
pp. 509-513
Author(s):  
Juan José Soto Castillo ◽  
Jesús Loarce-Martos ◽  
José Miguel Blanc-Molina
Keyword(s):  
Differential Diagnosis ◽  
Febrile Neutropenia ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Large Vessel ◽  
Rare Entity ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Oncological Patients ◽  
Stimulating Factor

Summary: Aortitis is a rare entity that may cause fever of unknown origin. This entity has a wide various etiologies, which main cause is rheumatologic, but not only. Iatrogenia has also been described, including chemotherapy and supporting treatment (like granulocyte-colony stimulating factor in oncological patients. The evidence in favour of this pharmacological link is growing. The differential diagnosis of fever, in febrile neutropenia setting, can be difficult to itemize.

Infective endocarditis as a complication of longstanding ventriculoatrial (VA) shunt: the importance of suspicion and early investigation in patients with VA shunt and pyrexia of unknown origin

2021 ◽  
Vol 14 (1) ◽  
pp. e237161
Author(s):  
Rosa Sun ◽  
Richard Warwick ◽  
Stuart Harrisson ◽  
Nageswar Bandla
Keyword(s):  
Infective Endocarditis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Early Investigation ◽  
Window Of Opportunity ◽  
Pyrexia Of Unknown Origin ◽  
Cerebrospinal Fluid Diversion ◽  
Prompt Diagnosis

Ventriculoatrial (VA) shunts are a method of cerebrospinal fluid diversion, which nowadays are infrequently seen in medical practice. Infective endocarditis (IE) can occur as rare complications of VA shunts, through the introduction of a foreign body close to the tricuspid valve. We report a case of infective endocarditis, that is, in a patient with VA shunt for congenital hydrocephalus. We present the case to highlight the importance of early investigation for IE in patients with fever of unknown origin and shunt in situ, as rapid deterioration can occur and be fatal. We also discuss past experience reported in the literature on the role of cardiothoracic intervention. Prompt diagnosis and early cardiothoracic referral for surgery are crucial, there may only be a narrow window of opportunity for intervention before patients develop fulminant sepsis.

Select Opportunistic Infections in Adult Patients With HIV

2012 ◽  
Author(s):  
John W. Wilson ◽  
Lynn L. Estes
Keyword(s):  
Risk Factors ◽  
Drug Therapy ◽  
Opportunistic Infections ◽  
Immunosuppressive Drug ◽  
Atypical Presentation ◽  
Chest Discomfort ◽  
Exertional Dyspnea ◽  
Interstitial Infiltrate ◽  
Immunosuppressive Drug Therapy ◽  
Chronic Corticosteroid

•Risk factors: Ubiquitous organism; CD4 count <200/mcL; chronic corticosteroid or other immunosuppressive drug therapy•Clinical disease• Exertional dyspnea, fever, nonproductive cough, and chest discomfort that gets worse over days to weeks• Hypoxemia; chest radiographs vary (most commonly show diffuse bilateral, symmetrical interstitial infiltrate but may be relatively normal early in course and can have atypical presentation)...

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