Diffusion of Two Botulinum Toxins Type A on the Forehead: Double-Blinded, Randomized, Controlled Study

2014 ◽  
Vol 40 (2) ◽  
pp. 184-192 ◽  
Author(s):  
Hai-Yan Jiang ◽  
Shujun Chen ◽  
Jun Zhou ◽  
Kong Kwok Leung ◽  
Peiying Yu
Keyword(s):  
Type A ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Botulinum Toxins ◽  
Randomized Controlled ◽  
Double Blinded ◽  
Botulinum Toxins Type A

Botulinum Toxin Type A Injection for Mammoplasty and Abdominoplasty Scar Management: A Split-Scar Double-Blinded Randomized Controlled Study

2020 ◽  
Vol 44 (6) ◽  
pp. 2270-2276
Author(s):  
Robabeh Abedini ◽  
Neda Mehdizade Rayeni ◽  
Shahriar Haddady Abianeh ◽  
Javad Rahmati ◽  
Amir Teymourpour ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Scar Management ◽  
Double Blinded

scholarly journals Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study

2020 ◽  
Vol 46 (11) ◽  
pp. 2015-2025 ◽  
Author(s):  
Sung Yeon Hwang ◽  
◽  
Seung Mok Ryoo ◽  
Jong Eun Park ◽  
You Hwan Jo ◽  
...  
Keyword(s):  
Septic Shock ◽  
Combination Therapy ◽  
Vitamin C ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Double Blinded

scholarly journals Cryoneurolysis for cervicogenic headache – a double blinded randomized controlled study

2019 ◽  
Vol 20 (1) ◽  
pp. 39-50
Author(s):  
Gunnvald Kvarstein ◽  
Henrik Högström ◽  
Sara Maria Allen ◽  
Jan Henrik Rosland
Keyword(s):  
Pain Relief ◽  
Local Anaesthetic ◽  
Cervicogenic Headache ◽  
Pain Clinic ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Group Differences ◽  
Anatomical Landmarks ◽  
Randomized Controlled ◽  
Double Blinded

AbstractBackground and aimsCervicogenic headache (CEH) is a debilitating condition and analgesics have limited effect. Percutaneous cryoneurolysis is thus still in use although the clinical evidence is lacking. We present a randomized, controlled study to assess the clinical efficacy of cryoneurolysis compared with a corticosteroid combined with a local anaesthetic.MethodsIn a university-based outpatient pain clinic we performed a randomized, double blinded, comparative study with an 18-week follow-up. After positive diagnostic test blocks 52 eligible patients were randomly allocated in a ratio of 3:2, 31 participants to occipital cryoneurolysis and 21 participants to injections of 1 mL methylprednisolone 40 mg/mL (Depo-Medrol®) combined with 1 mL bupivacaine 5 mg/mL.ResultsWe observed a significant pain reduction of more than 50% in both treatment groups, slightly improved neck function and reduced number of opioid consumers. After 6–7-weeks, however, pain intensity increased gradually, but did not reach baseline within 18 weeks. Although cryoneurolysis provided a more prolonged effect, the group differences did not reach statistical significance. Health related quality of life and psychological distress improved minimally. A large number reported minor and transient side effects, but we found no significant group differences. After 18 weeks, 29% rated the headache as much improved, and 12 (24%) somewhat improved, but a large proportion (78%) reported need for further intervention/treatment.ConclusionsCryoneurolysis provided substantial, but temporary pain relief, and the effect was not significantly different from injections of a corticosteroid combined with a local anaesthetic. Participants were selected by a single test block, and the neurolytic procedure was guided by anatomical landmarks and nerve stimulation. A stricter patient selection and an ultrasound-guided technique might have improved the results. Cryoneurolysis provides temporary pain relief not significantly superior to corticosteroid injection, and the results question the value of occipital cryoneurolysis for a chronic pain condition like CEH.ImplicationsOccipital cryoneurolysis may be considered when non-invasive treatments appear insufficient, but only for patients who have responded substantially to test blocks. A risk of local scar and neuroma formation by repeated cryoneurolysis, leading to neuropathic pain has been discussed by other researchers.

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