Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

2013 ◽  
Vol 39 (4) ◽  
pp. 627-633 ◽  
Author(s):  
Katie Xiaoyi Wang ◽  
Adam Meekings ◽  
Joachim W. Fluhr ◽  
Gordon McKenzie ◽  
David A. Lee ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Optical Coherence ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery

scholarly journals Line-Field Confocal Optical Coherence Tomography May Enhance Monitoring of Superficial Basal Cell Carcinoma Treated with Imiquimod 5% Cream: A Pilot Study

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4913
Author(s):  
Anna Elisa Verzì ◽  
Giuseppe Micali ◽  
Francesco Lacarrubba
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Line Field ◽  
Non Invasive ◽  
Superficial Basal Cell Carcinoma

Line-field confocal optical coherence tomography (LC-OCT) is a novel, non-invasive technique for real-time skin imaging. Imiquimod (IQ) 5% cream is an immune response modifier currently approved for the treatment of small, superficial basal cell carcinoma (BCC). The aim of this study was to investigate if LC-OCT may be useful to enhance the treatment monitoring of BCC. Twenty superficial BCCs from 12 patients were treated with IQ 5% cream once daily, five days a week, for six weeks. Clinical and LC-OCT evaluations were performed at baseline and 4 weeks after the end of treatment. At the end of the study, 13 lesions showed a complete clinical and LC-OCT response, 4 lesions a partial clinical and LC-OCT response, and 3 lesions a complete clinical response but residual tumoral signs at LC-OCT. Our pilot study suggests that LC-OCT may represent a promising tool able to enhance the evaluation of the treatment response of BCCs to non-invasive treatments. In our case series, its use highlighted, through a detailed, fast, and complete examination of the treated area, three cases of residual BCC that otherwise would have gone undetected at clinical examination. Future studies on larger series of patients treated with different modalities and with a longer follow-up are advisable.

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