Endocytoscopic observation of various esophageal lesions at ×600: can nuclear abnormality be recognized?

2014 ◽  
Vol 28 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Y. Kumagai ◽  
K. Kawada ◽  
M. Higashi ◽  
T. Ishiguro ◽  
J. Sobajima ◽  
...  
Keyword(s):  
Nuclear Abnormality

Congenital Dyserythropoietic Anaemia with Peculiar Nuclear Abnormality

2009 ◽  
Vol 15 (4) ◽  
pp. 261-271 ◽  
Author(s):  
S. Weiss ◽  
U. Gafter ◽  
E. Lyn ◽  
M. Dialdetti
Keyword(s):  
Nuclear Abnormality

scholarly journals Cytogenotoxicity of Abattoir Effluent in Clarias gariepinus (Burchell, 1822) Using Micronucleus Test

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Chibuisi G. Alimba ◽  
Ebenezer O. Ajayi ◽  
Titilayo Hassan ◽  
Akindayo A. Sowunmi ◽  
Adekunle A. Bakare
Keyword(s):  
Micronucleus Test ◽  
Tap Water ◽  
Clarias Gariepinus ◽  
Oxygen Demand ◽  
Negative Control ◽  
Control Fish ◽  
Dependent Manner ◽  
Nuclear Abnormality ◽  
And Control ◽  
Positive Controls

The cytogenotoxic potential of abattoir effluent from Bodija, Nigeria, was investigated using micronucleus test in Clarias gariepinus. Fish was exposed to five different concentrations: 0.2, 0.4, 0.8, 1.6, and 3.1% of the effluent for 7, 14, and 28 days. Tap water and 0.02 mL/L of benzene were used as negative and positive controls, respectively. Physicochemical parameters and heavy metals were analyzed in the effluent in accordance with standard methods. After exposure, blood was collected from the treated and control fish and slides were prepared for micronuclei (MN) and nuclear abnormality evaluation in the peripheral erythrocytes. The effluent induced significant (p<0.05) increase in the frequency of MN in a time dependent manner. Similarly, the frequency of total nuclear abnormalities (blebbing, notch, bud, binucleation, and vacuolation) was higher in the exposed fish than the negative control. Electrical conductivity, nitrate, biochemical oxygen demand, chemical oxygen demand, arsenic, and copper analyzed in the effluent may have provoked the observed cytogenetic damage. The findings herein suggest the presence of clastogens and cytotoxins in Bodija abattoir wastewater which are capable of increasing genomic instability in aquatic biota.

scholarly journals Chromatin Clumping in Mature Leukocytes: A Hitherto Unrecognized Abnormality

Blood ◽  
1970 ◽  
Vol 35 (5) ◽  
pp. 637-658 ◽  
Author(s):  
SUSAN S. GUSTKE ◽  
GARY A. BECKER ◽  
JOHN C. GARANCIS ◽  
NICHOLAS F. GEIMER ◽  
ANTHONY V. PISCIOTTA
Keyword(s):  
Electron Microscopy ◽  
Stem Cell ◽  
Family Members ◽  
Erythroid Cells ◽  
Ineffective Erythropoiesis ◽  
Leukemic Transformation ◽  
Bacterial Killing ◽  
Nuclear Abnormality ◽  
Cellular Aggregation ◽  
Functional Defect

Abstract A 62-year-old man and a 73-year-old woman were found to have a nuclear abnormality characterized by exaggerated clumping of the chromatin in the mature granulocytic and erythroid cells. The mature granulocytes showed loss of normal segmentation. The abnormality was not noted in other family members and appeared to be related to an atypical leukemic process. The nuclear abnormality was shown to be associated with a defect in cellular production within the marrow. Granulocyte precursors and normoblasts incorporated 3H-TdR but did not divide. Electron microscopy suggested the distribution of more than normal quantities of heterochromatin to mature leukocytes. Ferrokinetic studies disclosed ineffective erythropoiesis. The sharing of this abnormality by the myeloid and erythroid cells suggests a common stem cell origin. A functional defect of phagocytosis and cellular aggregation was demonstrated in the neutrophils, but bacterial killing was not affected. The nuclear anomaly described herein may be a pre-leukemic abnormality. Since this paper was submitted for publication, we have treated two more patients with an identical nuclear defect; an 82-year-old woman and a 79-year-old man. The woman succumbed of acute leukemic transformation, while the man is still alive.

scholarly journals Morphometrical Analysis of Nuclear Abnormality of Tubular Tumors of the Stomach with Image Processing

1992 ◽  
Vol 83 (3) ◽  
pp. 294-299 ◽  
Author(s):  
Tatsuya Ishido ◽  
Hajime Yamaguchi ◽  
Shigeaki Yoshida ◽  
Shin Tonouchi
Keyword(s):  
Image Processing ◽  
Morphometrical Analysis ◽  
Nuclear Abnormality

Significance of Borderline Nuclear Abnormality In Cervical Smears

Cytopathology ◽  
1992 ◽  
Vol 3 (2) ◽  
pp. 85-91 ◽  
Author(s):  
D. M. PARHAM ◽  
E. K. WIREDU ◽  
K. A. HUSSEIN
Keyword(s):  
Cervical Smears ◽  
Nuclear Abnormality
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