Metabolically healthy obesity and cardiovascular events: A risk of obesity

2021 ◽  
Author(s):  
Tomoyuki Kawada
Keyword(s):  
Cardiovascular Events ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

Metabolically Healthy Obesity and Cardiovascular Events. A Nationwide Cohort Study

2021 ◽  
Author(s):  
Grégoire Fauchier ◽  
Arnaud Bisson ◽  
Alexandre Bodin ◽  
Julien Herbert ◽  
Carl Semaan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Events ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysis

2015 ◽  
Vol 23 (9) ◽  
pp. 956-966 ◽  
Author(s):  
Nathalie Eckel ◽  
Karina Meidtner ◽  
Tamara Kalle-Uhlmann ◽  
Norbert Stefan ◽  
Matthias B Schulze
Keyword(s):  
Systematic Review ◽  
Cardiovascular Events ◽  
Meta Analysis ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

Metabolically healthy obesity and metabolically obese normal weight: a review

2021 ◽  
Vol 77 (1) ◽  
pp. 175-189 ◽  
Author(s):  
Saioa Gómez-Zorita ◽  
Maite Queralt ◽  
Maria Angeles Vicente ◽  
Marcela González ◽  
María P. Portillo
Keyword(s):  
Normal Weight ◽  
Metabolically Healthy Obesity ◽  
Metabolically Obese Normal Weight ◽  
Metabolically Healthy

scholarly journals Early determinants of metabolically healthy obesity in young adults: study of the Northern Finland Birth Cohort 1966

2018 ◽  
Vol 42 (10) ◽  
pp. 1704-1714 ◽  
Author(s):  
Rozenn Nedelec ◽  
Jari Jokelainen ◽  
Jouko Miettunen ◽  
Aimo Ruokonen ◽  
Karl-Heinz Herzig ◽  
...  
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

scholarly journals Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study

2018 ◽  
Vol 65 (6) ◽  
pp. 669-675 ◽  
Author(s):  
Takuro Okamura ◽  
Yoshitaka Hashimoto ◽  
Masahide Hamaguchi ◽  
Akihiro Ohbora ◽  
Takao Kojima ◽  
...  
Keyword(s):  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Metabolically Healthy Obesity ◽  
Cross Sectional ◽  
Metabolically Healthy

Current prospects of metabolically healthy obesity

2021 ◽  
pp. 100361
Author(s):  
Mousa Numan Ahmad ◽  
Ayat Abdulla Zawatia
Keyword(s):  
Metabolically Healthy Obesity ◽  
Metabolically Healthy

scholarly journals Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants

Diabetologia ◽  
2021 ◽  
Author(s):  
Ziyi Zhou ◽  
John Macpherson ◽  
Stuart R. Gray ◽  
Jason M. R. Gill ◽  
Paul Welsh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Diseases ◽  
Population Based ◽  
Incident Diabetes ◽  
Uk Biobank ◽  
Metabolically Healthy Obesity ◽  
Wide Range ◽  
Metabolically Healthy

Abstract Aims/hypothesis People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. This study aims to examine the associations of MHO with a wide range of obesity-related outcomes. Methods This is a population-based prospective cohort study of 381,363 UK Biobank participants with a median follow-up of 11.2 years. MHO was defined as having a BMI ≥ 30 kg/m2 and at least four of the six metabolically healthy criteria. Outcomes included incident diabetes and incident and fatal atherosclerotic CVD (ASCVD), heart failure (HF) and respiratory diseases. Results Compared with people who were not obese at baseline, those with MHO had higher incident HF (HR 1.60; 95% CI 1.45, 1.75) and respiratory disease (HR 1.20; 95% CI 1.16, 1.25) rates, but not higher ASCVD. The associations of MHO were generally weaker for fatal outcomes and only significant for all-cause (HR 1.12; 95% CI 1.04, 1.21) and HF mortality rates (HR 1.44; 95% CI 1.09, 1.89). However, when compared with people who were metabolically healthy without obesity, participants with MHO had higher rates of incident diabetes (HR 4.32; 95% CI 3.83, 4.89), ASCVD (HR 1.18; 95% CI 1.10, 1.27), HF (HR 1.76; 95% CI 1.61, 1.92), respiratory diseases (HR 1.28; 95% CI 1.24, 1.33) and all-cause mortality (HR 1.22; 95% CI 1.14, 1.31). The results with a 5 year landmark analysis were similar. Conclusions/interpretation Weight management should be recommended to all people with obesity, irrespective of their metabolic status, to lower risk of diabetes, ASCVD, HF and respiratory diseases. The term ‘MHO’ should be avoided as it is misleading and different strategies for risk stratification should be explored. Graphical abstract

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