Safety and Effectiveness of Metformin in Patients with Reduced Renal Function: A Systematic Review

2021 ◽  
Author(s):  
Jeremy Orloff ◽  
Jea Young Min ◽  
Alvin Mushlin ◽  
James Flory
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Reduced Renal Function

scholarly journals Hypertension in autosomal dominant polycystic kidney disease: a meta-analysis

2016 ◽  
Vol 101 (12) ◽  
pp. 1142-1147 ◽  
Author(s):  
Matko Marlais ◽  
Oliver Cuthell ◽  
Dean Langan ◽  
Jan Dudley ◽  
Manish D Sinha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Meta Analysis ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Hypertension In Children ◽  
Reduced Renal Function

ContextAutosomal dominant polycystic kidney disease (ADPKD) is a common disorder that can cause hypertension during childhood, but the true prevalence of hypertension during childhood is not known.ObjectiveWe undertook a systematic review and meta-analysis to determine the prevalence of hypertension in children with ADPKD.Data sourcesSystematic review of articles published between 1980 and 2015 in MEDLINE and EMBASE.Study selectionStudies selected by two authors independently if reporting data on prevalence of hypertension in children and young persons aged <21 years with a diagnosis of ADPKD. Observational series were included with study populations of >15 children. Articles were excluded if inadequate diagnostic criteria for hypertension were used. Studies with selection bias were included but analysed separately.Data extractionData extracted on prevalence of hypertension, proteinuria and reduced renal function using standardised form. Meta-analysis was performed to calculate weighted mean prevalence.Results903 articles were retrieved from our search; 14 studies met the inclusion criteria: 1 prospective randomised controlled trial; 8 prospective observational studies; and 5 retrospective cross-sectional studies. From 928 children with clinically confirmed ADPKD, 20% (95% CI 15% to 27%) were hypertensive. The estimated prevalence of proteinuria in children with ADPKD is 20% (8 studies; 95% CI 9% to 40%) while reduced renal function occurred in 8% (5 studies; 95% CI 2% to 26%).LimitationsStudies showed a high degree of methodological heterogeneity (I2=73.4%, τ2=0.3408, p<0.0001). Most studies did not use ambulatory blood pressure (BP) monitoring to diagnose hypertension.ConclusionsIn this meta-analysis we estimate 20% of children with ADPKD have hypertension. In the population, many children with ADPKD are not under regular follow-up and remain undiagnosed. We recommend that all children at risk of ADPKD have regular BP measurement.

scholarly journals SUBCLINICAL HYPOTHYROIDISM;

2012 ◽  
Vol 20 (01) ◽  
pp. 023-029
Author(s):  
MOHAMMAD ASIF ◽  
ATIF ULLAH ◽  
MUHAMMAD AKRAM
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Subclinical Hypothyroidism ◽  
Renal Mass ◽  
Medical Institute ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Endocrine Abnormality ◽  
Reduced Renal Function

Chronic kidney disease (CKD) is characterized by progressive destruction of renal mass with irreversible sclerosis andloss of nephrons.Various metabolic, hematological and endocrine abnormalities are known to occur in CKD. Subclinical hypothyroidismis an important endocrine abnormality associated with a greater cardiovascular risk, atherosclerosis and an important factor forprogression of renal disease in such patients. Objective: To calculate the frequency of subclinical hypothyroidism in predialysis CKDpatients. Design: Cross sectional survey. Setting: Pathology Department Post Graduate Medical Institute, Lahore. Period: 06 months(June 2011 to Dec 2011). Results: 210 patients were included in the study. Serum creatinine. TSH and FT4 were measured and therelevant data was entered in predesigned proforma. 19.5 % of CKD population had subclinical hypothyroidism with slightly increasedpreponderance in females as compared to males and also increased frequency as the stage of CKD increased. Subclinicalhypothyroidism is more common in CKD population. Conclusions: Increased frequency of subclinical hypothyroidism was found inpatients with reduced renal function not on dialysis. 19.5% of CKD population on conservative management had labortary evidence ofthyroid dysfunction.

Appropriateness of enoxaparin prescribing in patients with reduced renal function

2012 ◽  
Vol 19 (2) ◽  
pp. 91.3-92
Author(s):  
P. Hidalgo Collazos ◽  
L. García-López ◽  
L. Gómez-Sayago ◽  
T. Rico-Gutiérrez ◽  
R. Aguilella-Vizcaíno ◽  
...  
Keyword(s):  
Renal Function ◽  
Reduced Renal Function

Drugs and the kidney

2010 ◽  
pp. 4174-4188
Author(s):  
Aine Burns ◽  
Caroline Ashley
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Critical Role ◽  
The Body ◽  
Medical Practitioners ◽  
Drug Dosing ◽  
Estimated Glomerular Filtration Rates ◽  
Careful Thought ◽  
Reduced Renal Function

The kidney plays a critical role in the elimination of many drugs from the body, hence consideration should be given to a patient’s renal function whenever any drug is prescribed. Much kidney disease is unrecognized, but the widespread reporting of estimated glomerular filtration rates (eGFR) has brought greater awareness of the prevalence of chronic kidney disease (CKD) and thereby encouraged medical practitioners to take account of reduced renal function when prescribing. CKD is very often one of many coexisting comorbid conditions, especially in elderly patients, when particularly careful thought must be given to appropriate drug dosing and the possibility of drug interactions....

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