Do sodium‐glucose transporter‐2 inhibitors increase plasma glucagon by direct actions on the alpha‐cell? – and does the increase matter for the associated increase in endogenous glucose production?

2021 ◽  
Author(s):  
Rune E. Kuhre ◽  
Carolyn F. Deacon ◽  
Nicolai J. Wewer Albrechtsen ◽  
Jens J. Holst
Keyword(s):  
Glucose Transporter ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Alpha Cell ◽  
Plasma Glucagon ◽  
Glucose Transporter 2 ◽  
Endogenous Glucose

scholarly journals Regulation of Endogenous Glucose Production in Glucose Transporter 4 Over-Expressing Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52355 ◽  
Author(s):  
Eric D. Berglund ◽  
Candice Y. Li ◽  
Julio E. Ayala ◽  
Owen P. McGuinness ◽  
David H. Wasserman
Keyword(s):  
Glucose Transporter ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Glucose Transporter 4 ◽  
Endogenous Glucose

scholarly journals Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes of the young caused by HNF-1alpha gene mutations (MODY3)

2001 ◽  
pp. 45-49 ◽  
Author(s):  
E Guenat ◽  
G Seematter ◽  
J Philippe ◽  
E Temler ◽  
E Jequier ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Glucose Production ◽  
Glucagon Secretion ◽  
Insulin Dependent Diabetes Mellitus ◽  
Endogenous Glucose Production ◽  
Dependent Diabetes Mellitus ◽  
Plasma Glucagon ◽  
Functional Consequences ◽  
Insulin Dependent ◽  
Endogenous Glucose

Mutations of HNF-1alpha lead to severe beta cell dysfunction, resulting in decreased glucose-induced insulin secretion. HNF-1alpha is also expressed in liver, kidney and pancreatic alpha cells, but the functional consequences of HNF-1alpha mutations in these organs remain unknown. We therefore assessed the counterregulatory responses to hypoglycemia in six patients with HNF-1alpha mutations (MODY3), five patients with non-insulin-dependent diabetes mellitus (NIDDM) and in nine healthy controls. Plasma glucagon concentrations and endogenous glucose production were measured every 15 min during a hyperinsulinemic clamp with progressive hypoglycemia. Plasma glucagon concentrations were similar at basal glycemia (73+/-6, 69+/-5 and 69+/-7 ng/l) and reached peak values of 88+/-9, 88+/-11 and 89+/-7 ng/l at a glycemia of 3.6 mmol/l in MODY3 patients, patients with NIDDM and controls respectively (NS). Suppression of endogenous glucose production by insulin was blunted in MODY3 patients (3.3+/-1.2 micromol/kg per min) and in patients with NIDDM (4.4+/-0.6 micromol/kg per min) compared with controls (1.7+/-0.5 micromol/kg per min, P<0.05 compared with both MODY3 patients and patients with NIDDM). During hypoglycemia, endogenous glucose production increased to 8.6+/-2.1, 8.8+/-0.7 and 7.0+/-1.0 micromol/kg per min in MODY3 patients, patients with NIDDM and controls respectively (all NS). These data indicate that mutations of HNF-1alpha in MODY3 do not result in a decreased glucagon secretion or alterations of glucose production during hypoglycemia.

scholarly journals Endogenous glucose production after sequential meals in humans: evidence for more prolonged suppression after ingestion of a second meal

2018 ◽  
Vol 315 (5) ◽  
pp. E904-E911 ◽  
Author(s):  
Teddy Ang ◽  
Greg M. Kowalski ◽  
Clinton R. Bruce
Keyword(s):  
Real Life ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Eating Patterns ◽  
Plasma Glucagon ◽  
Healthy Individuals ◽  
Carbohydrate Ingestion ◽  
Single Meal ◽  
Endogenous Glucose ◽  
Insulin Responses

Single-meal studies have shown that carbohydrate ingestion causes rapid and persistent suppression of endogenous glucose production (EGP). However, little is known about the regulation of EGP under real-life eating patterns in which multiple carbohydrate-containing meals are consumed throughout the day. Therefore, we aimed to characterize the regulation of EGP in response to sequential meals, specifically during the breakfast-lunch transition. Nine healthy individuals (5 men, 4 women; 32 ± 2 yr; 25.0 ± 1.4 kg/m2) ingested two identical mixed meals, each containing 25 g of glucose, separated by 4 h, and EGP was determined by the variable infusion tracer-clamp approach. EGP was rapidly suppressed after both meals, with the pattern and magnitude of suppression being similar over the initial 75-min postmeal period. However, EGP suppression was more transient after breakfast compared with lunch, with EGP returning to basal rates 3 h after breakfast. In contrast, EGP remained in a suppressed state for the entire 4-h postlunch period. This occurred despite each meal eliciting similar plasma glucose and insulin responses. However, there was greater suppression of plasma glucagon levels after lunch, likely contributing to this response. These findings highlight the potential for distinct regulation of EGP with each meal of the day and suggest that EGP may be in a suppressed state for much of the day, since EGP did not return to basal rates even after a lunch meal containing a modest amount of carbohydrate.

155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 155-LB
Author(s):  
CAROLINA SOLIS-HERRERA ◽  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
HENRI HONKA ◽  
RUPAL PATEL ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Sglt2 Inhibition ◽  
Endogenous Glucose ◽  
Glucose Excretion

1832-P: Palmitic Acid Esters of Hydroxy Stearic Acids Reduce Endogenous Glucose Production through GPR43 Activation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1832-P
Author(s):  
ANNA SANTORO ◽  
PENG ZHOU ◽  
YAN ZHU ◽  
ODILE D. PERONI ◽  
ANDREW T. NELSON ◽  
...  
Keyword(s):  
Palmitic Acid ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose ◽  
Acid Esters

246-OR: Contribution of Plasma Glucose and Hormones to the Acute Compensatory Rise in Endogenous Glucose Production (EGP) during Glucosuria in T2D Patients

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 246-OR
Author(s):  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
NITCHAKARN LAICHUTHAI ◽  
JOHN M. ADAMS ◽  
MUHAMMAD ABDUL-GHANI ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose

1898-P: Colonic Short-Chain Fatty Acids Lower Endogenous Glucose Production

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1898-P
Author(s):  
ADELINA I.L. LANE ◽  
SAVANNA N. WENINGER ◽  
FRANK DUCA
Keyword(s):  
Fatty Acids ◽  
Glucose Production ◽  
Short Chain Fatty Acids ◽  
Endogenous Glucose Production ◽  
Short Chain ◽  
Endogenous Glucose ◽  
Chain Fatty Acids

691-P: Exercise Effect on Endogenous Glucose Production in Type 1 Diabetes: A Modeling Analysis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 691-P
Author(s):  
DAVIDE ROMERES ◽  
MICHELE SCHIAVON ◽  
ROBERTO VISENTIN ◽  
ANANDA BASU ◽  
CLAUDIO COBELLI ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Modeling Analysis ◽  
Exercise Effect ◽  
Endogenous Glucose

Endogenous glucose production in critical illness

2021 ◽  
Author(s):  
Nameer Al‐Yousif ◽  
Sagar Rawal ◽  
Michael Jurczak ◽  
Hussain Mahmud ◽  
Faraaz Ali Shah
Keyword(s):  
Critical Illness ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose
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