Bariatric surgery in the treatment of patients with obesity and type 1 diabetes: A retrospective study of clinical data

2021 ◽  
Author(s):  
Nagi Mohammed ◽  
Adam Buckley ◽  
Mohgah Elsheikh ◽  
Matthew Allum ◽  
Sara Suliman ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Type 1 Diabetes ◽  
Retrospective Study ◽  
Clinical Data

scholarly journals Insulin doses requirements in patients with type 1 diabetes using glargine U300 or degludec in routine clinical practice

2021 ◽  
pp. jim-2020-001633
Author(s):  
Florentino Carral San Laureano ◽  
Mariana Tomé Fernández-Ladreda ◽  
Ana Isabel Jiménez Millán ◽  
Concepción García Calzado ◽  
María del Carmen Ayala Ortega
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Practice ◽  
Retrospective Study ◽  
Real World ◽  
Glycosylated Hemoglobin ◽  
Routine Clinical Practice ◽  
Insulin Analogs ◽  
Total P ◽  
Real Clinical Practice

There are not many real-world studies evaluating daily insulin doses requirements (DIDR) in patients with type 1 diabetes (T1D) using second-generation basal insulin analogs, and such comparison is necessary. The aim of this study was to compare DIDR in individuals with T1D using glargine 300 UI/mL (IGlar-300) or degludec (IDeg) in real clinical practice. An observational, retrospective study was designed in 412 patients with T1D (males: 52%; median age 37.0±13.4 years, diabetes duration: 18.7±12.3 years) using IDeg and IGla-300 ≥6 months to compare DIDR between groups. Patients using IGla-300 (n=187) were more frequently males (59% vs 45.8%; p=0.004) and had lower glycosylated hemoglobin (HbA1c) (7.6±1.2 vs 8.1%±1.5%; p<0.001) than patients using IDeg (n=225). Total (0.77±0.36 unit/kg/day), basal (0.43±0.20 unit/kg/day) and prandial (0.33±0.23 unit/kg/day) DIDR were similar in IGla-300 and IDeg groups. Patients with HbA1c ≤7% (n=113) used significantly lower basal (p=0.045) and total (p=0.024) DIDR, but not prandial insulin (p=0.241), than patients with HbA1c between 7.1% and 8% and >8%. Patients using IGla-300 and IDeg used similar basal, prandial and total DIDR regardless of metabolic control subgroup. No difference in basal, prandial and total DIDR was observed between patients with T1D using IGla-300 or IDeg during at least 6 months in routine clinical practice.

scholarly journals Bariatric Surgery and Type 1 Diabetes: Unanswered Questions

2020 ◽  
Vol 11 ◽  
Author(s):  
Emmanouil Korakas ◽  
Aikaterini Kountouri ◽  
Athanasios Raptis ◽  
Alexander Kokkinos ◽  
Vaia Lambadiari
Keyword(s):  
Bariatric Surgery ◽  
Type 1 Diabetes

scholarly journals A Multiple Hypothesis Approach to Estimating Meal Times in Individuals With Type 1 Diabetes

2019 ◽  
Vol 15 (1) ◽  
pp. 141-146
Author(s):  
John P. Corbett ◽  
Marc D. Breton ◽  
Stephen D. Patek
Keyword(s):  
Type 1 Diabetes ◽  
Clinical Data ◽  
Estimation Error ◽  
Average Error ◽  
Accurate Information ◽  
Data Set ◽  
Multiple Hypothesis ◽  
Meal Time ◽  
Normally Distributed

Introduction: It is important to have accurate information regarding when individuals with type 1 diabetes have eaten and taken insulin to reconcile those events with their blood glucose levels throughout the day. Insulin pumps and connected insulin pens provide records of when the user injected insulin and how many carbohydrates were recorded, but it is often unclear when meals occurred. This project demonstrates a method to estimate meal times using a multiple hypothesis approach. Methods: When an insulin dose is recorded, multiple hypotheses were generated describing variations of when the meal in question occurred. As postprandial glucose values informed the model, the posterior probability of the truth of each hypothesis was evaluated, and from these posterior probabilities, an expected meal time was found. This method was tested using simulation and a clinical data set ( n = 11) and with either uniform or normally distributed ( μ = 0, σ = 10 or 20 minutes) prior probabilities for the hypothesis set. Results: For the simulation data set, meals were estimated with an average error of −0.77 (±7.94) minutes when uniform priors were used and −0.99 (±8.55) and −0.88 (±7.84) for normally distributed priors ( σ = 10 and 20 minutes). For the clinical data set, the average estimation error was 0.02 (±30.87), 1.38 (±21.58), and 0.04 (±27.52) for the uniform priors and normal priors ( σ = 10 and 20 minutes). Conclusion: This technique could be used to help advise physicians about the meal time insulin dosing behaviors of their patients and potentially influence changes in their treatment strategy.

scholarly journals Bariatric surgery in patients with type 1 diabetes: special considerations are warranted

2019 ◽  
Vol 10 ◽  
pp. 204201881882220 ◽  
Author(s):  
Zohar Landau ◽  
Galit Kowen-Sandbank ◽  
Daniela Jakubowicz ◽  
Asnat Raziel ◽  
Nasser Sakran ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Glucose Control ◽  
Healthcare Services ◽  
Short And Long Term ◽  
The Mean

Objective: We examined short and long-term outcomes of bariatric surgery in patients with obesity and type 1 diabetes mellitus (T1DM). Methods: We reviewed the records of all adults insured by Maccabi Healthcare Services during 2010 -2015, with body mass index (BMI) ⩾30 kg/m2 and T1DM; and compared weight reduction and glucose control according to the performance of bariatric surgery. BMI and glycated hemoglobin (HbA1c) levels were extracted for baseline and every 6 months, for a mean 3.5 years. Results: Of 52 patients, 26(50%) underwent bariatric surgery. Those who underwent surgery were more often female and with a longer duration of diabetes. Immediately postoperative, 4(15%) developed diabetic ketoacidosis, while 6(23%) experienced severe hypoglycemic episodes. The mean BMI decreased among surgery patients: from 39.5±4.4 to 30.1±5.0 kg/m2 ( p < 0.0001); and increased among those who did not undergo surgery: from 33.6±3.9 to 35.1±4.4 kg/m2 ( p = 0.49). The mean HbA1c level decreased during the first 6 months postoperative: from 8.5±0.9% to 7.9±0.9%; however, at the end of follow-up, was similar to baseline, 8.6±2.0% (p = 0.87). For patients who did not undergo surgery, the mean HbA1c increased from 7.9±1.9% to 8.6±1.5% ( p = 0.09). Conclusions: Among individuals with obesity and T1DM, weight loss was successful after bariatric surgery, but glucose control did not improve. The postoperative risks of diabetic ketoacidosis and severe hypoglycemic episodes should be considering when performing bariatric surgery in this population.

Incidence of fractures in patients with type 1 diabetes mellitus—a retrospective study with 4420 patients

2020 ◽  
Vol 31 (7) ◽  
pp. 1315-1322 ◽  
Author(s):  
U. Stumpf ◽  
P. Hadji ◽  
L. van den Boom ◽  
W. Böcker ◽  
K. Kostev
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Retrospective Study ◽  
Type 1 Diabetes Mellitus

Bariatric surgery in type 1 diabetes

2013 ◽  
Vol 60 (1) ◽  
pp. 46-47
Author(s):  
Rebeca Reyes Garcia ◽  
Manuel Romero Muñoz ◽  
Héctor Galbis Verdú
Keyword(s):  
Bariatric Surgery ◽  
Type 1 Diabetes

Bariatric Surgery in Patients with Type 1 Diabetes: A Meta-analysis of 104 Cases

2015 ◽  
Vol 11 (6) ◽  
pp. S166-S168
Author(s):  
Ali Aminian ◽  
John Kirwan ◽  
Bartolome Burguera ◽  
Sangeeta Kashyap ◽  
Philip Schauer ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Type 1 Diabetes ◽  
Meta Analysis
Sign in / Sign up

Export Citation Format

Share Document