Sodium‐glucose cotransporter‐2 inhibitors and the risk of urinary tract infection among diabetic patients in Japan: Target trial simulation using a nationwide administrative claims database

2021 ◽  
Author(s):  
Yoshinori Takeuchi ◽  
Hiraku Kumamaru ◽  
Yasuhiro Hagiwara ◽  
Hiroki Matsui ◽  
Hideo Yasunaga ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Patients ◽  
Administrative Claims ◽  
Target Trial ◽  
Claims Database ◽  
Sodium Glucose Cotransporter ◽  
Trial Simulation

scholarly journals Isolation and diagnosis of bacteria causing urinary tract infection in pregnant and non pregnant females with diabetes mellitus type2

2019 ◽  
Vol 29 (4) ◽  
pp. 23
Author(s):  
Faraj Hatto Joni
Keyword(s):  
Diabetes Mellitus ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pregnant Women ◽  
Diabetic Patients ◽  
Microscopical Examination ◽  
Symptomatic Infection ◽  
Pregnant Females ◽  
Esherichia Coli

Diabetic patients have more outcomes of urinary tract infection than non diabetes, mortality of urinary tract infection (UTI) is 5 times higher in patients with diabetes old age, the incidence of urinary tract infection in pregnant women is slightly higher than non pregnant women, urinary tract infection in pregnant women either as a symptomatic bacteriiuria or symptomatic infection, which is more complication during pregnancy this present study was done in March 2016 to July 2016, the patients were females, total samples of 80 patient of pregnant and non pregnant with diabetes mellitus, selected from medical and general surgical wards, the samples were sending to teaching laboratories from the same hospital, the present study show that the incidence of UTI at non pregnant diabetic women occur at age (9-11) years (45%), the most common causative agents of UTI in diabetic pregnant females is Esherichia coli 20(50%), the results of microscopical examination of urine of pregnant with diabetes mellitus of urine of pregnant with diabetes mellitus revealed that (43), pyuria and (28) had crystals, and the result of microscopical examination of urine of non pregnant females with diabetes mellitus revealed that the common causative agent is Esherichia coli 3(30%), (9) had pyuria and (4) had crystals.

Health guidelines to prevent recurrence of urinary tract infection among diabetic patients

2018 ◽  
Vol 15 (3) ◽  
pp. 236
Author(s):  
SharbatT Hassanine ◽  
ManarF Hamza ◽  
EglalH Abdel-Hakeim
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Patients

scholarly journals In-Vitro Biofilm Formation and Antimicrobial Resistance of Escherichia coli in Diabetic and Nondiabetic Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Sunayana Raya ◽  
Ankit Belbase ◽  
Laxmi Dhakal ◽  
Krishna Govinda Prajapati ◽  
Reena Baidya ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diabetic Patients ◽  
Microtitre Plate ◽  
Plate Method ◽  
E Coli ◽  
Biofilm Production

Background. Diabetic patients are more susceptible to urinary tract infection compared to nondiabetic patients, Escherichia coli being the most common uropathogen causing UTI. Unreasonable and incorrect antibiotic prescription for UTI in these patients may induce the development of antibiotic-resistant urinary pathogens resulting in delayed recovery and longer hospitalization. In addition to these, biofilm forming capacity of the pathogen may worsen the problem. The main aim of this cross-sectional study (conducted from March to September 2015) is to detect the biofilm forming capacity of UTI causing micro-organisms and compare the antibiotic resistance pattern of Escherichia coli, the most common cause of UTI, which will help the physician in choosing the best antibiotic. Method. Total of 1,099 clean-catch mid stream urine (CCMSU) was processed by standard microbiological technique; 182 were from the diabetic group and 917 nondiabetic. Following identification, all isolates were subjected to antibiotic susceptibility testing using modified Kirby-Bauer disc diffusion method. In-vitro biofilm forming capacity of the isolates were detected by Microtitre plate method. The data were analyzed using SPSS software 16. Result. Urinary tract infection was found to be significantly higher in diabetic patients (42.9%) compared to nondiabetic patients (17.4%) with Escherichia coli as the most common uropathogen in both diabetic and nondiabetic groups. Similarly, UTI was more common in elderly population (29.5%). Imipenem, nitrofurantoin and amikacin were found to be the most effective drug for uropathogenic E. coli in both diabetic and nondiabetic patients, whereas amoxicillin, ciprofloxacin, and cotrimoxazole were least effective. Of the total bacterial isolates, 43.3% showed positive results for in-vitro biofilm production by the Microtitre plate method. A significantly higher resistance rate was observed among biofilm producing E. coli for quinolones, cotrimoxazole, and third generation cephalosporin ceftriaxone. Most of the biofilm producers (79.5%) were found to be MDR (p-value 0.015). Conclusion. Elderly populations with diabetes are at a higher risk of UTI. Higher biofilm production and resistance to in-use antimicrobial agents in this study render its inefficacy for empirical treatment and point out the importance of biofilm screening to ensure the effective management of infection.

scholarly journals Prevalence of Urinary Tract Infection and Antimicrobial Susceptibility among Diabetic Patients with Controlled and Uncontrolled Glycemia in Kuwait

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
May Sewify ◽  
Shinu Nair ◽  
Samia Warsame ◽  
Mohamed Murad ◽  
Asma Alhubail ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Resistance Pattern ◽  
Clear Correlation ◽  
Diabetic Patients ◽  
Antimicrobial Drugs ◽  
Age And Gender ◽  
And Gender ◽  
The Impact

Diabetic patients have higher risk of urinary tract infection (UTI). In the present study, we investigated the impact of glycemic control in diabetic patients on UTI prevalence, type of strains, and their antimicrobial drugs susceptibility. This study was conducted on urine samples from 722 adult diabetic patients from which 252 (35%) samples were positive for uropathogens. Most UTI cases occurred in the uncontrolled glycemic group (197 patients) versus 55 patients with controlled glycemia. Higher glycemic levels were measured in uncontrolled glycemia group (HbA1c = 8.3 ± 1.5 and 5.4 ± 0.4, resp.,P<0.0001). Females showed much higher prevalence of UTI than males in both glycemic groups (88.5% and 11.5%, resp.,P<0.0001). In the uncontrolled glycemia group 90.9% of the UTI cases happened at ages above 40 years and a clear correlation was obtained between patient age ranges and number of UTI cases (r=0.94;P=0.017), whereas in the group with controlled glycemia no trend was observed.Escherichia coliwas the predominant uropathogen followed byKlebsiella pneumoniaeand they were together involved in 76.2% of UTI cases. Those species were similarly present in both diabetic groups and displayed comparable antibiotic resistance pattern. These results highlight the importance of controlling glycemia in diabetic patients to reduce the UTI regardless of age and gender.

scholarly journals ISOLATION AND CHARACTERISATION OF ANTI-BACTERIAL RESISTANCE PATTERNS OF BACTERIAL ISOLATES FROM URINARY TRACT INFECTION IN DIABETICS

2021 ◽  
pp. 57-59
Author(s):  
HARIKRISHNAN S. ◽  
ROSY VENNILA ◽  
R. MONICA
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Resistance ◽  
Resistance Pattern ◽  
Diabetic Patients ◽  
E Coli ◽  
Drug Of Choice ◽  
Resistance Patterns ◽  
Common Infections

Objective: Urinary tract infection (UTI) is one of the most common infections observed in diabetic patients. This study is aimed at identifying the organisms with their anti-bacterial resistance pattern. Methods: A total of 400 diabetic patients over a period of nine months presenting with symptom s of urinary tract infection were taken for the study. Their urine were cultured and an antibiogram done. Results: E. coli, Klebsiella and Enterococci were the commonest organism found. It was found that E. coli, which was the commonest organism E. Coli was sensitive to Norfloxacin and resistant to Ciprofloxacin. Conclusion: Empirical treatment with ciprofloxacin, Which is considered the drug of choice, will lead to failure of treatment.

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