Normal insulin sensitivity, glucose tolerance, gut incretin and pancreatic hormone responses in adults with atopic dermatitis

2020 ◽  
Vol 22 (11) ◽  
pp. 2161-2169
Author(s):  
Lise Gether ◽  
Jacob P. Thyssen ◽  
Mette Gyldenløve ◽  
Bolette Hartmann ◽  
Jens J. Holst ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Hormone Responses ◽  
Pancreatic Hormone

Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance

1993 ◽  
Vol 128 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Susanne Lanng ◽  
Birger Thorsteinsson ◽  
Michael E Røder ◽  
Cathrine Ørskov ◽  
Jens J Holst ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Pancreatic Polypeptide ◽  
Oral Glucose ◽  
C Peptide ◽  
Control Subjects ◽  
Gut Hormone ◽  
Patient Groups ◽  
Hormone Responses

Pancreatic and gut hormone responses to oral glucose, and insulin sensitivity were studied in cystic fibrosis patients with normal (N= 14), impaired (N=4), and diabetic (N= 12) glucose tolerance, and in 10 control subjects, and beta cell responses to oral glucose and intravenous glucagon were compared. Compared to control subjects, initial insulin and C-peptide responses to oral glucose were lower in all patient groups, and decreased with decreasing glucose tolerance. Insulin sensitivity in patients with impaired and diabetic glucose tolerance was lower than in control subjects. The 6 min post-glucagon C-peptide concentration was positively correlated with the initial insulin response to oral glucose. Fasting levels of pancreatic polypeptide, pancreatic glucagon, total glucagon, glucagon-like peptide-1 7-36 amide, and gastric inhibitory polypeptide were normal in all patient groups. Following oral glucose, pancreatic polypeptide responses were absent in all patients, suppressibility of pancreatic glucagon secretion was increasingly impaired with decreasing glucose tolerance, and gut hormone levels were normal. In conclusion, at cystic fibrosis (a) insulin secretion is impaired even when glucose tolerance and insulin sensitivity are within the normal range, (b) the glucagon test gives valid estimates of residual beta cell function, (c) pancreatic polypeptide response to oral glucose is absent, (d) glucagon suppressibility decreases with decreasing glucose tolerance, and (e) the enteroinsular axis is intact.

1576-P: Correlation Analysis between Insulin Sensitivity, Branched-Chain Acid, and Adiponectin Levels in Japanese Individuals with Varying Degrees of Glucose Tolerance

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1576-P
Author(s):  
ERI AMANO ◽  
KUMIKO YOSHIMURA ◽  
SHOGO FUNAKOSHI ◽  
SEIKI HIRANO ◽  
SATOKO OHMI ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Correlation Analysis ◽  
Glucose Tolerance ◽  
Branched Chain
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