scholarly journals The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 ( GLP ‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP ‐1 receptor agonists

2020 ◽  
Vol 22 (10) ◽  
pp. 1886-1891 ◽  
Author(s):  
Shweta Urva ◽  
Tamer Coskun ◽  
Corina Loghin ◽  
Xuewei Cui ◽  
Emily Beebe ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Receptor Agonist ◽  
The Novel ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Long Acting

scholarly journals GLP-1 Receptor Agonists in Type 2 Diabetes and Beyond – New Insights 2015

2015 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Baptist Gallwitz ◽  
Keyword(s):  
Type 2 Diabetes ◽  
European Association ◽  
The Novel ◽  
Diabetes Therapy ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Treatment Of Obesity ◽  
Long Acting

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were introduced for type 2 diabetes therapy nearly 10 years ago, among them short-acting compounds on the basis of the GLP-1-like peptide exendin-4 (exenatide and lixisenatide) and a long-acting GLP-1 RA based on the human GLP-1 sequence (liraglutide). Recently, two novel long-acting GLP-1 RAs on the basis of human GLP-1 sequence, for onceweekly application, have been approved for therapy of type 2 diabetes. Additionally, liraglutide has been approved for treatment of obesity at a higher dose than that used for diabetes therapy. This mini-review gives a short overview of the novel long-acting GLP-1 RAs albiglutide and dulaglutide and also reviews the studies of liraglutide in treatment of obesity leading to its approval for this use. These studies were largely presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in fall 2014.

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