scholarly journals The effect of small doses of fructose and allulose on postprandial glucose metabolism in type 2 diabetes: A double-blind, randomized, controlled, acute feeding, equivalence trial

2018 ◽  
Vol 20 (10) ◽  
pp. 2361-2370 ◽  
Author(s):  
Jarvis C. Noronha ◽  
Catherine R. Braunstein ◽  
Andrea J. Glenn ◽  
Tauseef A. Khan ◽  
Effie Viguiliouk ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Postprandial Glucose ◽  
Double Blind ◽  
Equivalence Trial ◽  
Randomized Controlled ◽  
Small Doses

scholarly journals Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial

Diabetes Care ◽  
2020 ◽  
Vol 43 (8) ◽  
pp. 1813-1821 ◽  
Author(s):  
Christopher K. Rayner ◽  
Linda E. Watson ◽  
Liza K. Phillips ◽  
Kylie Lange ◽  
Michelle J. Bound ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Controlled Trial ◽  
Gastric Emptying ◽  
Glucose Metabolism ◽  
Controlled Trial ◽  
Postprandial Glucose ◽  
Randomized Controlled

scholarly journals Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study

2019 ◽  
Vol 59 (7) ◽  
pp. 2969-2983 ◽  
Author(s):  
Angela Horvath ◽  
Bettina Leber ◽  
Nicole Feldbacher ◽  
Norbert Tripolt ◽  
Florian Rainer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Pilot Study ◽  
Glucose Metabolism ◽  
Life Assessment ◽  
Gut Permeability ◽  
Double Blind ◽  
Double Blind Placebo

Abstract Purpose Diabesity, the combination of obesity and type 2 diabetes, is an ever-growing global health burden. Diabesity-associated dysbiosis of the intestinal microbiome has gained attention as a potential driver of disease and, therefore, a possible therapeutic target by means of pro- or prebiotic supplementation. This study tested the effects of a multispecies synbiotic (i.e. a combination of probiotics and prebiotics) on glucose metabolism, gut microbiota, gut permeability, neutrophil function and quality of life in treatment-experienced diabesity patients. Methods A randomized, double-blind, placebo-controlled pilot study with 26 diabesity patients was conducted in which patients received a daily dose of a multispecies probiotic and a prebiotic (or a placebo) for 6 months. Results There were no changes in glucose metabolism or mixed meal tolerance test responses throughout the study. The analysis of secondary outcomes revealed beneficial effects on hip circumference [− 1 (95% CI − 4; 3) vs +3 (− 1; 8) cm, synbiotics vs. placebo, respectively, p = 0.04], serum zonulin [− 0.04 (− 0.2; 0.1) vs +0.3 (− 0.05; 0.6) ng/ml, p = 0.004)] and the physical role item of the SF36 quality of life assessment [+ 5.4 (− 1.7; 12.5) vs − 5.0 (− 10.1; 0.2) points, p = 0.02] after 3 months of intervention, and lipoprotein (a) [− 2.1 (− 5.7; 1.6) vs +3.4 (− 0.9; 7.9) mg/dl, p = 0.02] after 6 months. There were no significant differences in alpha or beta diversity of the microbiome between groups or time points. Conclusions Glucose metabolism as the primary outcome was unchanged during the intervention with a multispecies synbiotic in patients with diabesity. Nevertheless, synbiotics improved some symptoms and biomarkers of type 2 diabetes and aspects of quality of life suggesting a potential role as adjuvant tool in the management of diabesity. Graphic abstract

23-OR: The Effect of 14-Day Atorvastatin Treatment on Postprandial Glucose Metabolism in Healthy Males—A Link to Why Statin Therapy Increases the Risk of Type 2 Diabetes?

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 23-OR
Author(s):  
MARTIN L. THOMASEN ◽  
DAVID P. SONNE ◽  
MARTIN L. KÅRHUS ◽  
ANDREAS BRØNDEN ◽  
BART STAELS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Statin Therapy ◽  
Postprandial Glucose ◽  
Atorvastatin Treatment ◽  
Healthy Males
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