scholarly journals Greater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast‐acting insulin aspart compared with insulin aspart

2018 ◽  
Vol 20 (7) ◽  
pp. 1615-1622 ◽  
Author(s):  
Ananda Basu ◽  
Thomas R. Pieber ◽  
Ann K. Hansen ◽  
Stefanie Sach‐Friedl ◽  
Lars Erichsen ◽  
...  
Keyword(s):  
Insulin Aspart ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Glucose Disappearance ◽  
Acting Insulin ◽  
Endogenous Glucose ◽  
Fast Acting

Enteral infusion of glucose at rates approximating EGP enhances glucose disposal but does not cause hypoglycemia

2003 ◽  
Vol 285 (2) ◽  
pp. E280-E286 ◽  
Author(s):  
Farhad Zangeneh ◽  
Rita Basu ◽  
Pankaj Shah ◽  
Puneet Arora ◽  
Michael Camilleri ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Glucose Sensor ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Glucose Disposal ◽  
Wild Type ◽  
Glucose Disappearance ◽  
Endogenous Glucose ◽  
Glucose Plasma ◽  
Portal Infusion

Portal infusion of glucose at rates approximating endogenous glucose production (EGP) causes paradoxical hypoglycemia in wild-type but not GLUT2 null mice, implying activation of a specific portal glucose sensor. To determine whether this occurs in humans, glucose containing [3-3H]glucose was infused intraduodenally at rates of 3.1 mg · kg-1 · min-1 ( n = 5), 1.55 mg · kg-1 · min-1 ( n = 9), or 0/0.1 mg · kg-1 · min-1 ( n = 9) for 7 h in healthy nondiabetic subjects. [6,6-2H2]glucose was infused intravenously to enable simultaneous measurement of EGP, glucose disappearance, and the rate of appearance of the intraduodenally infused glucose. Plasma glucose concentrations fell ( P < 0.01) from 90 ± 1 to 84 ± 2 mg/dl during the 0/0.1 mg · kg-1 · min-1 id infusions but increased ( P < 0.001) to 104 ± 5 and 107 ± 3 mg/dl, respectively, during the 1.55 and 3.1 mg · kg-1 · min-1 id infusions. In contrast, insulin increased ( P < 0.05) during the 1.55 and 3.0 mg · kg-1 · min-1 infusions, reaching a peak of 10 ± 2 and 18 ± 5 μU/ml, respectively, by 2 h. Insulin concentrations then fell back to concentrations that no longer differed by study end (7 ± 1 vs. 8 ± 1 μU/ml). This resulted in comparable suppression of EGP by study end (0.84 ± 0.2 and 0.63 ± 0.1 mg · kg-1 · min-1). Glucose disappearance was higher ( P < 0.01) during the final hour of the 3.1 than 1.55 mg · kg-1 · min-1 id infusion (4.47 ± 0.2 vs. 2.6 ± 0.1 mg · kg-1 · min-1), likely because of the slightly, but not significantly, higher glucose and insulin concentrations. We conclude that, in contrast to mice, selective portal glucose delivery at rates approximating EGP does not cause hypoglycemia in humans.

Evaluation of Early Postprandial Suppression of Endogenous Glucose Production with Faster Aspart vs. Insulin Aspart

2017 ◽  
Vol 41 (5) ◽  
pp. S70
Author(s):  
Jina Hahn ◽  
Ananda Basu ◽  
Thomas R. Pieber ◽  
Ann Kathrine Hansen ◽  
Stefanie Sach-Friedl ◽  
...  
Keyword(s):  
Insulin Aspart ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose

Adaptive changes in rates of appearance and disappearance of glucose in dogs following step changes in the rate of glucose infusion

1968 ◽  
Vol 46 (3) ◽  
pp. 391-398 ◽  
Author(s):  
G. Hetenyi Jr. ◽  
G. A. Wrenshall
Keyword(s):  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Glucose Infusion ◽  
Glucose Turnover ◽  
Glucose Disappearance ◽  
Endogenous Production ◽  
Endogenous Glucose ◽  
Diabetic Dogs ◽  
Pancreatectomized Dogs

The intravenous infusion of glucose at rates corresponding to 17–79% of the endogenous (hepatic) rate of glucose production decreased the latter in both normal and diabetic dogs. The increase in the rate of the exogenous infusion and the decrease in the rate of endogenous production were found to be positively correlated. The correlation between the change in the rate of glucose disappearance (utilization plus excretion) and the change in the rate of the exogenous infusion was significant in normal but not in diabetic dogs. The infusion of galactose had no effect on endogenous glucose production. Infusions into the cephalic vein or into the carotid artery were equally effective in decreasing endogenous glucose production. It appears that the rate of endogenous (hepatic) glucose production adapts to an exogenous glucose infusion in both normal and diabetic dogs. Such an adaptation in the rate of glucose disappearance (disposal) was observed only in normal but not in pancreatectomized dogs. Thus the role of the release of insulin in such adaptation is to increase the disposal rather than to decrease the rate of the endogenous production of glucose. The specificity of the adaptive mechanism is demonstrated by the ineffectiveness of galactose in altering glucose turnover.

155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 155-LB
Author(s):  
CAROLINA SOLIS-HERRERA ◽  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
HENRI HONKA ◽  
RUPAL PATEL ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Sglt2 Inhibition ◽  
Endogenous Glucose ◽  
Glucose Excretion

1832-P: Palmitic Acid Esters of Hydroxy Stearic Acids Reduce Endogenous Glucose Production through GPR43 Activation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1832-P
Author(s):  
ANNA SANTORO ◽  
PENG ZHOU ◽  
YAN ZHU ◽  
ODILE D. PERONI ◽  
ANDREW T. NELSON ◽  
...  
Keyword(s):  
Palmitic Acid ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose ◽  
Acid Esters

1037-P: Efficacy and Safety of Fast-Acting Insulin Aspart in Adults with T2D with Different Insulin Requirements

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1037-P
Author(s):  
WENDY LANE ◽  
MAGNUS EKELUND ◽  
ÓLÖF THÓRISDÓTTIR ◽  
ESTEBAN JÓDAR ◽  
ALEJANDRA OVIEDO ◽  
...  
Keyword(s):  
Insulin Aspart ◽  
Efficacy And Safety ◽  
Insulin Requirements ◽  
Acting Insulin ◽  
Fast Acting

246-OR: Contribution of Plasma Glucose and Hormones to the Acute Compensatory Rise in Endogenous Glucose Production (EGP) during Glucosuria in T2D Patients

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 246-OR
Author(s):  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
NITCHAKARN LAICHUTHAI ◽  
JOHN M. ADAMS ◽  
MUHAMMAD ABDUL-GHANI ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Endogenous Glucose

1898-P: Colonic Short-Chain Fatty Acids Lower Endogenous Glucose Production

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1898-P
Author(s):  
ADELINA I.L. LANE ◽  
SAVANNA N. WENINGER ◽  
FRANK DUCA
Keyword(s):  
Fatty Acids ◽  
Glucose Production ◽  
Short Chain Fatty Acids ◽  
Endogenous Glucose Production ◽  
Short Chain ◽  
Endogenous Glucose ◽  
Chain Fatty Acids
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