scholarly journals Single‐dose euglycaemic clamp studies demonstrating pharmacokinetic and pharmacodynamic similarity between MK ‐1293 insulin glargine and originator insulin glargine ( L antus) in subjects with type 1 diabetes and healthy subjects

2017 ◽  
Vol 20 (2) ◽  
pp. 400-408 ◽  
Author(s):  
Michael F. Crutchlow ◽  
John S. Palcza ◽  
Kate M. Mostoller ◽  
Chantal D. Mahon ◽  
April M. Barbour ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
Insulin Glargine ◽  
Healthy Subjects ◽  
Euglycaemic Clamp

scholarly journals Single‐dose new insulin glargine 300  U/ml provides prolonged, stable glycaemic control in J apanese and E uropean people with type 1 diabetes

2014 ◽  
Vol 17 (3) ◽  
pp. 254-260 ◽  
Author(s):  
M. Shiramoto ◽  
T. Eto ◽  
S. Irie ◽  
A. Fukuzaki ◽  
L. Teichert ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
Glycaemic Control ◽  
Insulin Glargine

Glycaemic control and hypoglycaemia with new insulin glargine 300 U/mL in people with type 1 diabetes (EDITION 4)

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
M Ziemen ◽  
RM Bergenstal ◽  
MC Riddle ◽  
M Rojeski ◽  
M Espinasse ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
Insulin Glargine

Use of insulin glargine throughout pregnancy in 102 women with type 1 diabetes

2010 ◽  
Vol 36 (3) ◽  
pp. 209-212 ◽  
Author(s):  
J. Lepercq ◽  
S. Jacqueminet ◽  
S. Hieronimus ◽  
J. Timsit ◽  
A. Grimaldi
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Glargine

scholarly journals Day-to-Day Variations in Fasting Plasma Glucose Do Not Influence Gastric Emptying in Subjects With Type 1 Diabetes

2020 ◽  
Author(s):  
Lea Aigner ◽  
Björn Becker ◽  
Sonja Gerken ◽  
Daniel R. Quast ◽  
Juris J. Meier ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gastric Emptying ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Chronic Hyperglycemia ◽  
Fasting Plasma

<b>Objective:</b> Acute experimental variations in glycemia decelerate (hyperglycemia) or accelerate (hypoglycemia) gastric emptying. Whether spontaneous variations in fasting plasma glucose (FPG) have a similar influence on gastric emptying is yet unclear. <p><b>Research design and methods:</b> Gastric emptying of a mixed meal was prospectively studied three times in 20 patients with type 1 diabetes and 10 healthy subjects with normal glucose tolerance using a <sup>13</sup>C-CO<sub>2</sub> octanoate breath test with Wagner-Nelson analysis. The velocity of gastric emptying was related to fasting plasma glucose (FPG) measured before the test (grouped as low, intermediate, or high). In addition, gastric emptying data from 255 patients with type 1 diabetes studied for clinical indications were compared by tertiles of baseline FPG. </p> <p><b>Results:</b> Despite marked variations in FPG (by 4.8 (3.4; 6.2) mmol/l), gastric emptying did not differ between the three prospective examinations in patients with type 1 diabetes (D T<sub>1/2</sub> between highest and lowest FPG: 1 [95 % CI: -35; 37] min; p = 0.90). The coefficient of variation for T<sub>1/2 </sub>determined three times was 21.0 %. Similar results at much lower variations in FPG were found in healthy subjects. In the cross-sectional analysis, gastric emptying did not differ between the tertiles of FPG (D T<sub>1/2</sub> between highest and lowest FPG: 7 [95 % CI: - 10; 23] min; p = 0.66), when FPG varied by 7.2 (6.7; 7.8) mmol/l. However, higher HbA<sub>1c</sub> was significantly related to slower gastric emptying.</p> <p><b>Conclusions:</b> Day-to-day variations in FPG not induced by therapeutic measures do not influence gastric emptying significantly. These findings are in contrast with those obtained after rapidly clamping plasma glucose in the hyper- or hypoglycemic concentrations range and challenge the clinical importance of short-term glucose fluctuations for gastric emptying in type 1-diabetic patients. Rather, chronic hyperglycemia is associated with slowed gastric emptying.</p>

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