scholarly journals Projected long‐term outcomes in patients with type 1 diabetes treated with fast‐acting insulin aspart vs conventional insulin aspart in the UK setting

2017 ◽  
Vol 19 (12) ◽  
pp. 1773-1780 ◽  
Author(s):  
David Russell‐Jones ◽  
Simon R. Heller ◽  
Sarah Buchs ◽  
Anna Sandberg ◽  
William J. Valentine ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Aspart ◽  
Long Term Outcomes ◽  
Acting Insulin ◽  
The Uk ◽  
Fast Acting

Glycemic Control with Fast-Acting Insulin Aspart According to Dose Adjustment Method in Type 1 Diabetes: A Post Hoc Analysis of Onset 8

2018 ◽  
Vol 42 (5) ◽  
pp. S47
Author(s):  
Rémi Rabasa-Lhoret ◽  
Thomas R. Pieber ◽  
John B. Buse ◽  
Ludger Rose ◽  
Anders Gorst-Rasmussen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Insulin Aspart ◽  
Dose Adjustment ◽  
Post Hoc Analysis ◽  
Adjustment Method ◽  
Acting Insulin ◽  
Post Hoc ◽  
Fast Acting

scholarly journals The association between anti‐insulin aspart antibodies and the pharmacokinetic and pharmacodynamic characteristics of fast‐acting insulin aspart in children and adolescents with type 1 diabetes

2020 ◽  
Vol 21 (5) ◽  
pp. 781-790
Author(s):  
Torben Biester ◽  
Thekla von dem Berge ◽  
Line Quist Bendtsen ◽  
Mette Dahl Bendtsen ◽  
Naveen Rathor ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Insulin Aspart ◽  
Acting Insulin ◽  
Fast Acting

scholarly journals Investigation of Pump Compatibility of Fast-Acting Insulin Aspart in Subjects With Type 1 Diabetes

2017 ◽  
Vol 12 (1) ◽  
pp. 145-151 ◽  
Author(s):  
Eric Zijlstra ◽  
Marek Demissie ◽  
Tina Graungaard ◽  
Tim Heise ◽  
Leszek Nosek ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Aspart ◽  
Acting Insulin ◽  
Fast Acting

scholarly journals Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial

2021 ◽  
Author(s):  
Melissa H. Lee ◽  
Barbora Paldus ◽  
Sara Vogrin ◽  
Dale Morrison ◽  
Dessi P. Zaharieva ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Aspart ◽  
Glucose Control ◽  
Primary Outcome ◽  
Closed Loop ◽  
Open Label ◽  
Modest Improvement ◽  
Acting Insulin ◽  
Fast Acting

<p><b>Objective</b></p> <p>To evaluate glucose control using fast-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp) delivered by the MiniMedä Advanced Hybrid Closed-Loop (AHCL) system in adults with type 1 diabetes. </p> <p><b>Research Design and Methods</b></p> <p>In this randomized, open-label, crossover study, participants were assigned to receive faster aspart or IAsp in random-order. Stages 1 and 2 comprised six-weeks in closed-loop; preceded by two-weeks in open-loop. This was followed by Stage 3, whereby participants changed directly back to the insulin formulation used in Stage 1 for one-week in CL. Participants chose their own meals except for two standardized meal tests; a missed and late meal bolus. Primary outcome was % sensor glucose time-in-range (TIR; 70-180mg/dL).</p> <p><b>Results</b></p> <p>Twenty-five adults (52% male) were recruited; median (IQR) age was 48 (37, 57) years, and HbA<sub>1c</sub> 7.0% (6.6, 7.2) (53 [49, 55] mmol/mol). Faster aspart demonstrated greater overall TIR compared with IAsp (82.3% [78.5, 83.7] vs. 79.6% [77.0, 83.4], respectively; mean difference 1.9% [0.5, 3.3]; <i>p</i>=0.007). Four-hour PPG TIR was higher using faster aspart compared with IAsp for all-meals combined (73.6% [69.4, 80.2] vs. 72.1% [64.5, 78.5], respectively; median difference 3.5% [1.0, 7.3]; <i>p</i>=0.003). There was no ketoacidosis or severe hypoglycemia. </p> <p><b>Conclusions</b></p> <p>Faster aspart safely improved glucose control compared with IAsp in a well-controlled group of adults with type 1 diabetes using AHCL. The modest improvement mainly related to mealtime glycemia. Whilst the primary outcome demonstrated statistical significance, the clinical impact may be small given an overall difference in TIR of 1.9%.</p>

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