Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates

2017 ◽  
Vol 19 (12) ◽  
pp. 1762-1772 ◽  
Author(s):  
Albert M. Kim ◽  
Veena R. Somayaji ◽  
Jennifer Q. Dong ◽  
Timothy P. Rolph ◽  
Yan Weng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Growth Factor ◽  
Bone Turnover ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Obese People ◽  
Weekly Administration ◽  
Turnover Markers ◽  
Long Acting

scholarly journals Fibroblast Growth Factor 21 (FGF21), Free Fatty Acid (FFA), High Sensitivity C-reactive Protein (hsCRP) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Among Indonesian Obese Non-Diabetic Males

2009 ◽  
Vol 1 (3) ◽  
pp. 76 ◽  
Author(s):  
Yani Lina ◽  
Gatot Susilo Lawrence ◽  
Andi Wijaya ◽  
Suryani As'ad
Keyword(s):  
Blood Pressure ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Sensitivity ◽  
Significant Negative Correlation ◽  
Fibroblast Growth Factor 21 ◽  
Compensatory Mechanism ◽  
Model Assessment ◽  
Fibroblast Growth ◽  
Cross Sectional

BACKGROUND: Fibroblast growth factor-21 (FGF21) is known as an important endocrine and paracrine regulator of metabolic homeostasis. Recent studies have shown that FGF21 attenuates lipolysis in human adipocytes, which is suggested as a FGF21's mechanism as anti-hyperlipidemia, anti-hyperglycemia and anti-obesity. The aim of this study was to measure the correlation between FGF21, FFA, hsCRP and HOMA-IR among Indonesian obese non diabetic males.METHOD: The study was observational with cross sectional design. The analysis was done in 137 subjects aged 30-60 years with non diabetic abdominal obesity. We measured the biochemical markers FGF21, FFA, hsCRP, fasting insulin and fasting glucose. We also measured weight, height, waist circumrefence (WC), creatinine, serum glutamin oxaloacetic transaminase (SGOT), and serum glutamic pyruvic transaminase (SGPT), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Correlation between markers was measured using Pearson and Spearman's analysis.  RESULT: There were significant positive correlations between FGF21-HOMA-IR (r=0.314, p=0.000); FGF21-WC (r=0.173, p=0.043); FFA=hsCRP (r=0.270, p=0.001); and WC-HOMA-IR (r=0.279, p=0.001). There was significant negative correlation between FGF21-FFA (r=-0.038, p=0.657) and FGF21-hsCRP (r=-0.061, p=0.482). CONCLUSION: In this study we found that although there was no significant correlation, FGF21 might act as an anti-lipolytic and anti-inflammation agent among Indonesian obese non-diabetic males. Our findings agree with results of previous studies that the positive correlation between FGF21-WC and FGF21-HOMA-IR moght occur as a compensatory mechanism or resistance to FGF21 in obesity.KEYWORDS: Obesity, FGF21, FFA, hsCRP, HOMA-IR

scholarly journals LBPS 02-06 PLASMA LEVEL OF FIBROBLAST GROWTH FACTOR 21 IS INDEPENDENTLY RELATED TO BLOOD PRESSURE

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e507
Author(s):  
Bmy Cheung ◽  
Chy Fong ◽  
C Chen ◽  
Awk Cho ◽  
Y Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Growth Factor ◽  
Plasma Level ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

Red raspberry (poly)phenolic extract improves diet-induced obesity, hepatic steatosis and insulin resistance in obese mice

2021 ◽  
pp. 1-14
Author(s):  
Haizhao Song ◽  
Xinchun Shen ◽  
Qiang Chu ◽  
Xiaodong Zheng
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Red Raspberry ◽  
Diet Induced Obesity ◽  
Phenolic Extract

BACKGROUND: Red raspberry (Rubus idaeus L.), a natural dietary source of (poly)phenols, has been used as medicine for centuries. OBJECTIVE: The purpose of this study is to determine the effect of a red raspberry (poly)phenolic extract (RPE) on diet-induced obesity, hepatic steatosis and insulin resistance, and elucidate the underlying molecular mechanisms. METHODS: Male specific pathogen-free C57BL/6J mice were randomly divided into three groups (n = 12 per group), and fed with low-fat diet (10% fat energy), high-fat diet (HFD, 45% fat energy), or HFD supplemented with RPE of 150 mg/kg body weight by intragastric administration for 14 weeks. Obesity-related biochemical indexes and hepatic gene expression levels were determined. The statistical analyses were conducted using one-way analysis of variance (ANOVA) followed by Duncan’s multiple range test. RESULTS: The body weight gain, steatosis grade scores and insulin resistance index in the RPE group decreased by 34.48% (P = 0.00), 58.82% (P = 0.00), and 53.77% (P = 0.00), respectively, compared to those in the HFD group. Moreover, RPE supplement significantly changed the expression profile of the genes involved in lipid metabolism and fibroblast growth factor 21 signaling pathway. CONCLUSIONS: This study demonstrated that RPE protected from diet-induced obesity and related metabolic disorders by improving the lipid metabolism and fibroblast growth factor 21 resistance.

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