scholarly journals Intraperitoneal insulin delivery provides superior glycaemic regulation to subcutaneous insulin delivery in model predictive control‐based fully‐automated artificial pancreas in patients with type 1 diabetes: a pilot study

2017 ◽  
Vol 19 (12) ◽  
pp. 1698-1705 ◽  
Author(s):  
Eyal Dassau ◽  
Eric Renard ◽  
Jérôme Place ◽  
Anne Farret ◽  
Marie‐José Pelletier ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pilot Study ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Artificial Pancreas ◽  
Insulin Delivery ◽  
Subcutaneous Insulin ◽  
Intraperitoneal Insulin

scholarly journals Run-to-Run Tuning of Model Predictive Control for Type 1 Diabetes Subjects: In Silico Trial

2009 ◽  
Vol 3 (5) ◽  
pp. 1091-1098 ◽  
Author(s):  
Lalo Magni ◽  
Marco Forgione ◽  
Chiara Toffanin ◽  
Chiara Dalla Man ◽  
Boris Kovatchev ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Sensitivity ◽  
Model Predictive Control ◽  
Predictive Control ◽  
In Silico ◽  
Insulin Pump ◽  
Artificial Pancreas ◽  
Arx Model ◽  
Starting Point

Background: The technological advancements in subcutaneous continuous glucose monitoring and insulin pump delivery systems have paved the way to clinical testing of artificial pancreas devices. The experience derived by clinical trials poses technological challenges to the automatic control expert, the most notable being the large interpatient and intrapatient variability and the inherent uncertainty of patient information. Methods: A new model predictive control (MPC) glucose control system is proposed. The starting point is an MPC algorithm applied in 20 type 1 diabetes mellitus (T1DM) subjects. Three main changes are introduced: individualization of the ARX model used for prediction; synthesis of the MPC law on top of the open-loop basal/bolus therapy; and a run-to-run approach for implementing day-by-day tuning of the algorithm. In order to individualize the ARX model, a sufficiently exciting insulin profile is imposed by splitting the premeal bolus into two smaller boluses (40% and 60%) injected 30 min before and 30 min after the meal. Results: The proposed algorithm was tested on 100 virtual subjects extracted from an in silico T1DM population. The trial simulates 44 consecutive days, during which the patient receives breakfast, lunch, and dinner each day. For 10 days, meals are multiplied by a random variable uniformly distributed in [0.5, 1.5], while insulin delivery is based on nominal meals. Moreover, for 10 days, either a linear increase or decrease of insulin sensitivity (±25% of nominal value) is introduced. Conclusions: The ARX model identification procedure offers an automatic tool for patient model individualization. The run-to-run approach is an effective way to auto-tune the aggressiveness of the closed-loop control law, is robust to meal variation, and is also capable of adapting the regulator to slow parameter variations, e.g., on insulin sensitivity.

Meal Estimation in Nonlinear Model Predictive Control for Type 1 Diabetes

2010 ◽  
Vol 43 (14) ◽  
pp. 1052-1057 ◽  
Author(s):  
Dimitri Boiroux ◽  
Daniel A. Finan ◽  
John Bagterp Jørgensen ◽  
Niels Kjølstad Poulsen ◽  
Henrik Madsen
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Nonlinear Model ◽  
Nonlinear Model Predictive Control

scholarly journals Performance of the Omnipod Personalized Model Predictive Control Algorithm with Meal Bolus Challenges in Adults with Type 1 Diabetes

2018 ◽  
Vol 20 (9) ◽  
pp. 585-595 ◽  
Author(s):  
Bruce A. Buckingham ◽  
Mark P. Christiansen ◽  
Gregory P. Forlenza ◽  
R. Paul Wadwa ◽  
Thomas A. Peyser ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Model Predictive Control ◽  
Predictive Control ◽  
Control Algorithm ◽  
Model Predictive Control Algorithm

scholarly journals Continuous Intraperitoneal Insulin Infusion Versus Subcutaneous Insulin Therapy in the Treatment of Type 1 Diabetes: Effects on Glycemic Variability

2015 ◽  
Vol 17 (6) ◽  
pp. 379-384 ◽  
Author(s):  
Peter R. van Dijk ◽  
Klaas H. Groenier ◽  
J. Hans DeVries ◽  
Reinold O.B. Gans ◽  
Nanno Kleefstra ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Insulin Infusion ◽  
Glycemic Variability ◽  
Subcutaneous Insulin ◽  
Intraperitoneal Insulin
Sign in / Sign up

Export Citation Format

Share Document