Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double-blind randomized controlled trial

2016 ◽  
Vol 18 (6) ◽  
pp. 633-637 ◽  
Author(s):  
S. Tepper ◽  
D. R. Shahar ◽  
D. Geva ◽  
S. Ish-Shalom
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Model Assessment ◽  
Double Blind ◽  
Healthy Men ◽  
Randomized Controlled ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

scholarly journals Effects of Vitamin D Supplementation on Body Composition and Metabolic Risk Factors in Men: A Randomized Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1894 ◽  
Author(s):  
Elisabeth Lerchbaum ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Martina Kollmann ◽  
Monika Wölfler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Body Composition ◽  
Controlled Trial ◽  
Anthropometric Measures ◽  
Double Blind ◽  
Significant Treatment ◽  
Metabolic Markers ◽  
Healthy Men ◽  
Randomized Controlled

Vitamin D might play a role in metabolic processes and obesity. We therefore examined vitamin D effects on metabolic markers and obesity in a randomized controlled trial (RCT). This is a post-hoc analysis of the Graz Vitamin D&TT-RCT, a single-center, double-blind, randomized placebo-controlled trial. We included 200 healthy men with serum 25-hydroxyvitamin D (25(OH) D) levels <75 nmol/L. Subjects received 20,000 IU of vitamin D3/week (n = 100) or placebo (n = 100) for 12 weeks. Outcome measures were metabolic markers, anthropometric measures, and body composition assessed by Dual-energy X-ray absorptiometry. One-hundred and ninety-two men completed the study. We found a significant treatment effect on fasting glucose/fasting insulin ratio (−5.3 (−10.4 to −0.2), p = 0.040), whereas we observed no significant effect on the remaining outcome parameters. In subgroup analyses of men with baseline 25(OH)D levels <50 nmol/L (n = 80), we found a significant effect on waist circumference (1.6 (0.3 to 2.9) cm, p = 0.012), waist-to-hip ratio (0.019 (0.002 to 0.036), p = 0.031), total body fat (0.029 (0.004 to 0.055) %, p = 0.026), and android fat (1.18 (0.11 to 2.26) %, p = 0.010). In middle-aged healthy men, vitamin D treatment had a negative effect on insulin sensitivity. In vitamin D deficient men, vitamin D has an unfavorable effect on central obesity and body composition.

scholarly journals Vitamin D₃ Supplementation in Batswana Children and Adults with HIV: A Pilot Double Blind Randomized Controlled Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117123 ◽  
Author(s):  
Andrew P. Steenhoff ◽  
Joan I. Schall ◽  
Julia Samuel ◽  
Boitshepo Seme ◽  
Marape Marape ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females

2010 ◽  
Vol 95 (10) ◽  
pp. 4643-4651 ◽  
Author(s):  
K. A. Ward ◽  
G. Das ◽  
S. A. Roberts ◽  
J. L. Berry ◽  
J. E. Adams ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Quantitative Computed Tomography ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
Vitamin D2 ◽  
Double Blind ◽  
Randomized Controlled ◽  
Jump Velocity

Context: There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone mineral accumulation. Objective: The aim was to determine the effect of vitamin D supplementation on the adolescent musculoskeletal system. Design and Setting: We conducted a community-based, double-blind, randomized controlled trial in a secondary school. Participants: Postmenarchal 12- to 14-yr-old females participated in the trial. Ninety-nine were screened, 73 were included in randomized controlled trial, and 69 completed the trial. There were no adverse events. Intervention: Four doses of 150,000 IU vitamin D2 (ergocalciferol) were given over 1 yr. Main Outcome Measures: Dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and jumping mechanography were used. Results: At follow-up, 25-hydroxyvitamin D [25(OH)D] status was 56.0 ± 8.9 nmol/liter in the intervention group and 15.8 ± 6.6 nmol/liter in controls. There were no effects of supplementation on bone; however, for muscle function, efficiency of movement improved in the vitamin D-treated group. There was an interaction between baseline 25(OH)D concentration and response to vitamin D supplementation for muscle jump velocity. Conclusions: Despite improvements in 25(OH)D status, treatment with vitamin D2 was not shown to increase mineral accretion, bone geometry or strength, muscle force, or power. There were greater increases in jump velocity in girls with the lowest baseline 25(OH)D concentrations. Lack of effect of intervention after the period of peak mineral and muscle mass accretion suggests that earlier action is required.

scholarly journals Sa2037 – Effect of Calcium and Vitamin D Supplementation on Bone Density in Patients with Cirrhosis- a Double-Blind Randomized Controlled Trial

2019 ◽  
Vol 156 (6) ◽  
pp. S-481
Author(s):  
Indu Grover ◽  
Deepak Gunjan ◽  
Namrata Singh ◽  
lakshmy Ramakrishnan ◽  
Ravinder Goswami ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Bone Density ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Double Blind ◽  
Randomized Controlled
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