Effects of subcutaneous, low-dose glucagon on insulin-induced mild hypoglycaemia in patients with insulin pump treated type 1 diabetes

2016 ◽  
Vol 18 (4) ◽  
pp. 410-418 ◽  
Author(s):  
A. Ranjan ◽  
S. Schmidt ◽  
S. Madsbad ◽  
J. J. Holst ◽  
K. Nørgaard
Diabetologia ◽  
2019 ◽  
Vol 62 (4) ◽  
pp. 582-592 ◽  
Author(s):  
Isabelle I. K. Steineck ◽  
Ajenthen Ranjan ◽  
Signe Schmidt ◽  
Trine R. Clausen ◽  
Jens J. Holst ◽  
...  

2020 ◽  
Author(s):  
Ajenthen G. Ranjan ◽  
Signe Schmidt ◽  
Jens J. Holst ◽  
Merete B. Christensen ◽  
Kirsten Nørgaard

AbstractObjectiveTo compare the glucose response to low-dose glucagon after high carbohydrate diet (HCD) versus low carbohydrate diet (LCD).MethodsIndividuals with insulin pump-treated type 1 diabetes went through 12 weeks of HCD (>250 g/day) and 12 weeks of LCD (<100 g/day) in random order and separated by 12 weeks. At end of each diet, mild hypoglycaemia was induced in the fasting state by a subcutaneous insulin bolus. When plasma glucose (PG) reached 3.9 mmol/L, 100 µg glucagon was given subcutaneously.ResultsFour of six participants completed both study visits while the remaining two only completed the study visit following LCD. They were 37 (28-52) years old (median (IQR)), had BMI 25.0 (24.5-25.2) kg/m2, and HbA1c 57 (55-59) mmol/mol or 7.4 (7.2-7.5) %. Daily carbohydrate intake was 95 (86-97) g during LCD and 254 (184-259) g during HCD. Compared with HCD, LCD had a significantly lower area under the PG curve from 0-120 min (521 (394-617) vs 663 (546-746) mmol/l x min, p=0.045) and insignificant lower incremental PG peak after the glucagon bolus (1.5 (0.6-3.2) vs 3.0 (2.2-4.2) mmol/L, p=0.317).ConclusionIn conclusion, the glucose response to low-dose glucagon was reduced after 12 weeks of LCD compared with HCD.


Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 253-LB
Author(s):  
SHEN DONG ◽  
CODY T. MOWERY ◽  
KEVAN C. HEROLD ◽  
STEPHEN E. GITELMAN ◽  
JONATHAN H. ESENSTEN ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 693-P
Author(s):  
BARTłOMIEJ MATEJKO ◽  
ŁUKASZ TOTA ◽  
MAłGORZATA MORAWSKA ◽  
SANDRA MROZINSKA ◽  
WANDA PILCH ◽  
...  

2020 ◽  
Vol 16 ◽  
Author(s):  
Beáta Erika Nagy ◽  
Brigitta Munkácsi ◽  
Karolina Eszter Kovács

Background & Introduction: Due to the increasing prevalence of type-1-diabetes an increasing number of studies draws investigation draws attention to its psychological effects and long-term consequences. As Type 1 Diabetes Mellitus is a chronic, non-curable, yet maintanable condition, with the affected children and their families facing a lifelong challenge. Our research focuses on the factors influencing adherence. Methods & Results: The adherence of youth was examined in a sample involving 114 patients treated in the Medical and Health Science Centre at the University of Debrecen by employing a new adherence questionnaire (DAQ abbreviated version, Munkácsi et al, 2019) (DAF 2017; N=114). The influence of socio-demographic variables and those related to the disease (age at the diagnosis, time elapsed since diagnosis, method of treatment, the time elapsed since the use of the pump) were measured by linear regression. Furthermore, the between-group comparisons were made by independent sample t-tests and variance analysis. The investigation was carried out between September 2017 and May 2018. The effect of using insulin pump as therapy is significant and positive (0.36. p=0.045). The adherence of the patients using insulin pump is higher while the effect of the age at the diagnosis has a significantly negative effect (-.247, p=0.035). Thus, earlier detection of the disease may lead to a higher level of adherence. The effects of the socio-demographic variables (gender, family structure, educational level, type of the settlement, owning sibling and birth order) were not significant (p>0.05). Regarding the between-group comparisons, a significant difference could be pointed out concerning the siblings and birth-order as the adherence of the those with siblings was higher (p=0.044). Moreover, concerning insulin pump therapy, the adherence of patients using pump was significantly better (p=0.048). Also, regarding the age of the diagnosis, the adherence of those diagnosed before 12 was seemingly higher (p=0.039). Concerning the other socio-demographical and disease-related variables, no significant differences could be detected. Conclusions: The results suggest that the treatment has an outstanding role in the adherence of the disease. Moreover, the role of the appropriate treatment, living conditions as well as the early diagnosis is relevant.


2021 ◽  
Author(s):  
Shane P Mooney ◽  
Gillian L Booth ◽  
Rayzel Shulman ◽  
Yingbo Na ◽  
Alanna Weisman ◽  
...  

2021 ◽  
Vol 102 ◽  
pp. 106279
Author(s):  
Holly K. O'Donnell ◽  
Tim Vigers ◽  
Suzanne Bennett Johnson ◽  
Laura Pyle ◽  
Nancy Wright ◽  
...  

2021 ◽  
Vol 3 ◽  
pp. 100083
Author(s):  
Beth Mumford ◽  
Victoria Oldham ◽  
Dawn Lee ◽  
Julie Jones ◽  
Gautam Das
Keyword(s):  

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