A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis

2015 ◽  
Vol 17 (5) ◽  
pp. 495-504 ◽  
Author(s):  
W.-C. Hsiao ◽  
K.-S. Shia ◽  
Y.-T. Wang ◽  
Y.-N. Yeh ◽  
C.-P. Chang ◽  
...  
Keyword(s):  
Food Intake ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1

Effects on Food Intake and Blood Lipids of Cannabinoid Receptor 1 Antagonist Treatment in Lean Rats

Obesity ◽  
2008 ◽  
Vol 16 (11) ◽  
pp. 2451-2455 ◽  
Author(s):  
Marianne F. Bennetzen ◽  
Maria P. Nielsen ◽  
Bjørn Richelsen ◽  
Steen B. Pedersen
Keyword(s):  
Food Intake ◽  
Blood Lipids ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1

scholarly journals A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3587
Author(s):  
Isabel van Ackern ◽  
Angela Kuhla ◽  
Björn Kuhla
Keyword(s):  
Food Intake ◽  
Food Deprivation ◽  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Related Protein ◽  
Cannabinoid Receptor 1 ◽  
Short Term ◽  
Nutrient Delivery ◽  
Increase Food Intake ◽  
Agouti Related Protein

The endocannabinoid system (ECS) plays a pivotal role in the complex control and regulation of food intake. Pharmacological ECS activation could improve health in energy-deficient stages by increasing food intake, at least in intermittent feeders. However, knowledge of the mechanism regulating appetite in species with continued nutrient delivery is incomplete. The objectives of this pilot study were to investigate the effect of the intraperitoneal (i.p.) administration of the endocannabinoids (ECs) anandamide (AEA) and 2-arachidonoylglycerol (2-AG) on food intake, plasma EC concentrations and hypothalamic orexigenic signaling, and to study how the circulatory EC tone changes in response to short-term food deprivation in dairy cows, a species with continuous nutrient delivery. The administration of EC resulted in higher food intake during the first hour after treatment. Plasma AEA concentrations were significantly increased 2.5 h after AEA injection, whereas plasma 2-AG concentrations remained unchanged 2.5 h after 2-AG injection. The hypothalamic immunoreactivity of cannabinoid receptor 1, agouti-related protein, and orexin-A was not affected by either treatment; however, neuropeptide Y and agouti-related protein mRNA abundances were downregulated in the arcuate nucleus of AEA-treated animals. Short-term food deprivation increased plasma 2-AG, while plasma AEA remained unchanged. In conclusion, i.p.-administered 2-AG and AEA increase food intake in the short term, but only AEA accumulates in the circulation. However, plasma 2-AG concentrations are more responsive to food deprivation than AEA.

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism

scholarly journals Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice

2016 ◽  
Vol 332 ◽  
pp. 217-222 ◽  
Author(s):  
Katrina L. Toal ◽  
Kelly E. Radziwon ◽  
David P. Holfoth ◽  
Matthew A. Xu-Friedman ◽  
Micheal L. Dent
Keyword(s):  
Knockout Mice ◽  
Cannabinoid Receptor ◽  
Frequency Difference ◽  
Gap Detection ◽  
Cannabinoid Receptor 1 ◽  
Detection Thresholds
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