scholarly journals Pancreatic beta cell signalling and function

2019 ◽  
Vol 36 (S1) ◽  
pp. 21-22
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Cell Signalling ◽  
And Function

scholarly journals Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Latif Rachdi ◽  
Alicia Maugein ◽  
Severine Pechberty ◽  
Mathieu Armanet ◽  
Juliette Hamroune ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Line ◽  
Gabab Receptor ◽  
Pancreatic Beta Cell ◽  
Beta Cell Line ◽  
Regulated Expression ◽  
And Function

W46 ROLE OF LIPOPROTEINS IN PANCREATIC BETA-CELL SURVIVAL, PROLIFERATION AND FUNCTION

2010 ◽  
Vol 11 (2) ◽  
pp. 10
Author(s):  
R.A. Sibler ◽  
S. Rütti ◽  
J.A. Ehses ◽  
R. Prazak ◽  
D.T. Meier ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Pancreatic Beta Cell ◽  
And Function

scholarly journals Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress

2013 ◽  
Vol 58 (3) ◽  
pp. 447-456 ◽  
Author(s):  
María Ángeles Martín ◽  
Elisa Fernández-Millán ◽  
Sonia Ramos ◽  
Laura Bravo ◽  
Luis Goya
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Cell Viability ◽  
Pancreatic Beta Cell ◽  
And Function ◽  
Beta Cell Viability

Maternal Obesity (MO) and Nutritional Excess (NE) Decrease Pancreatic Beta-Cell Numbers and Function by Late Gestation.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 493-493
Author(s):  
Liren Zhang ◽  
Sarah M Hein ◽  
Nathan M Long ◽  
Peter W Nathanielsz ◽  
Stephen P Ford
Keyword(s):  
Beta Cell ◽  
Maternal Obesity ◽  
Pancreatic Beta Cell ◽  
Late Gestation ◽  
Cell Numbers ◽  
And Function

scholarly journals Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

Diabetologia ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 128-140 ◽  
Author(s):  
K. Y. Chu ◽  
H. Li ◽  
K. Wada ◽  
J. D. Johnson
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Pancreatic Beta Cell ◽  
And Function

scholarly journals Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function

2022 ◽  
pp. 101592
Author(s):  
Manuel Blandino-Rosano ◽  
Pau Romaguera Llacer ◽  
Ashley Lin ◽  
Janardan K. Reddy ◽  
Ernesto Bernal-Mizrachi
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
And Function ◽  
Pancreatic Beta Cell Mass

scholarly journals Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

Diabetologia ◽  
2019 ◽  
Vol 62 (7) ◽  
pp. 1225-1236 ◽  
Author(s):  
Atsushi Obata ◽  
Tomohiko Kimura ◽  
Yoshiyuki Obata ◽  
Masashi Shimoda ◽  
Tomoe Kinoshita ◽  
...  
Keyword(s):  
Blood Flow ◽  
Beta Cell ◽  
Knockout Mice ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Vascular Endothelial ◽  
And Function ◽  
Pancreatic Beta Cell Mass ◽  
Mrna Expression Levels

AbstractAims/hypothesisThe aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function.MethodsMale vascular endothelial cell-specificPdpk1-knockout mice (Tie2+/−/Pdpk1flox/floxmice) and their wild-type littermates (Tie2−/−/Pdpk1flox/floxmice; control) were used for this study. At 12 weeks of age, an IPGTT and OGTT were conducted. Pancreatic blood flow was measured under anaesthesia. Thereafter, islet blood flow was measured by the microsphere method. Mice were killed for islet isolation and further functional study and mRNA was extracted from islets. Pancreases were sampled for immunohistochemical analyses.ResultsDuring the IPGTT, the blood glucose level was comparable between knockout mice and controlfloxmice, although serum insulin level was significantly lower in knockout mice. During the OGTT, glucose tolerance deteriorated slightly in knockout mice, accompanied by a decreased serum insulin level. During an IPGTT after pre-treatment with exendin-4 (Ex-4), glucose tolerance was significantly impaired in knockout mice. In fact, glucose-stimulated insulin secretion of isolated islets from knockout mice was significantly reduced compared with controlfloxmice, and addition of Ex-4 revealed impaired sensitivity to incretin hormones in islets of knockout mice. In immunohistochemical analyses, both alpha and beta cell masses were significantly reduced in knockout mice. In addition, the CD31-positive area was significantly decreased in islets of knockout mice. The proportion of pimonidazole-positive islets was significantly increased in knockout mice. mRNA expression levels related to insulin biosynthesis (Ins1,Ins2,Mafa,Pdx1andNeurod[also known asNeurod1]) and beta cell function (such asGckandSlc2a2) were significantly decreased in islets of knockout mice. Microsphere experiments revealed remarkably reduced islet blood flow. In addition, mRNA expression levels ofHif1α(also known asHif1a) and its downstream factors such asAdm,Eno1,Tpi1(also known asEts1),Hmox1andVegfa, were significantly increased in islets of knockout mice, indicating that islets of knockout mice were in a more hypoxic state than those of controlfloxmice. As a result, mRNA expression levels related to adaptive unfolded protein response and endoplasmic reticulum stress-related apoptotic genes were significantly elevated in islets of knockout mice. In addition, inflammatory cytokine levels were increased in islets of knockout mice. Electron microscopy revealed reduced endothelial fenestration and thickening of basal membrane of vascular endothelium in islets of knockout mice.Conclusions/interpretationVascular endothelial PDPK1 plays an important role in the maintenance of pancreatic beta cell mass and function by maintaining vascularity of pancreas and islets and protecting them from hypoxia, hypoxia-related endoplasmic reticulum stress, inflammation and distortion of capillary structure.

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