Overestimation of glomerular filtration rate calculated from creatinine as compared with cystatin C in patients with type 2 diabetes receiving sodium‐glucose cotransportor 2 inhibitors.

2021 ◽  
Author(s):  
Pensiri Choosongsang ◽  
Supamai Soonthornpun
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate

scholarly journals Comparison of Glomerular Filtration Rate Estimation from Serum Creatinine and Cystatin C in HNF1A-MODY and Other Types of Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Magdalena Szopa ◽  
Maria Kapusta ◽  
Bartlomiej Matejko ◽  
Tomasz Klupa ◽  
Teresa Koblik ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Serum Creatinine ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Glomerular Filtration Rate Estimation ◽  
Measured Gfr

Introduction. We previously showed that in HNF1A-MODY the cystatin C-based glomerular filtration rate (GFR) estimate is higher than the creatinine-based estimate. Currently, we aimed to replicate this finding and verify its clinical significance. Methods. The study included 72 patients with HNF1A-MODY, 72 with GCK-MODY, 53 with type 1 diabetes (T1DM), 70 with type 2 diabetes (T2DM), and 65 controls. Serum creatinine and cystatin C levels were measured. GFR was calculated from creatinine and cystatin C using the CKD-EPI creatinine equation (eGRF-cr) and CKD-EPI cystatin C equation (eGFR-cys), respectively. Results. Cystatin C levels were lower (p<0.001) in the control (0.70±0.13 mg/L), HNF1A (0.75±0.21), and GCK (0.72±0.16 mg/L) groups in comparison to those with either T1DM (0.87±0.15 mg/L) or T2DM (0.9±0.23 mg/L). Moreover, eGFR-cys was higher than eGRF-cr in HNF1A-MODY, GCK-MODY, and the controls (p=0.004; p=0.003; p<0.0001). This corresponded to 8.9 mL/min/1.73 m2, 9.7 mL/min/1.73 m2, and 16.9 mL/min/1.73 m2 of difference. Additionally, T1DM patients had higher eGFR-cr than eGFR-cys (11.6 mL/min/1.73 m2; p=0.0004); no difference occurred in T2DM (p=0.91). Conclusions. We confirmed that eGFR-cys values in HNF1A-MODY patients are higher compared to eGFR-cr. Some other differences were also described in diabetic groups. However, none of them appears to be clinically relevant.

scholarly journals The Error of Estimated GFR in Type 2 Diabetes Mellitus

2019 ◽  
Vol 8 (10) ◽  
pp. 1543 ◽  
Author(s):  
Sergio Luis-Lima ◽  
Tomás Higueras Linares ◽  
Laura Henríquez-Gómez ◽  
Raquel Alonso-Pescoso ◽  
Angeles Jimenez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate

Type 2 diabetes mellitus represents 30–50% of the cases of end stage renal disease worldwide. Thus, a correct evaluation of renal function in patients with diabetes is crucial to prevent or ameliorate diabetes-associated kidney disease. The reliability of formulas to estimate renal function is still unclear, in particular, those new equations based on cystatin-C or the combination of creatinine and cystatin-C. We aimed to assess the error of the available formulas to estimate glomerular filtration rate in diabetic patients. We evaluated the error of creatinine and/or cystatin-C based formulas in reflecting real renal function over a wide range of glomerular filtration rate (from advanced chronic kidney disease to hyperfiltration). The error of estimated glomerular filtration rate by any equation was common and wide averaging 30% of real renal function, and larger in patients with measured glomerular filtration rate below 60 mL/min. This led to chronic kidney disease stages misclassification in about 30% of the individuals and failed to detect 25% of the cases with hyperfiltration. Cystatin-C based formulas did not outperform creatinine based equations, and the reliability of more modern algorithms proved to be as poor as older equations. Formulas failed in reflecting renal function in type 2 diabetes mellitus. Caution is needed with the use of these formulas in patients with diabetes, a population at high risk for kidney disease. Whenever possible, the use of a gold standard method to measure renal function is recommended.

scholarly journals Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations?

Diabetologia ◽  
2011 ◽  
Vol 54 (12) ◽  
pp. 2987-2994 ◽  
Author(s):  
F. Iliadis ◽  
T. Didangelos ◽  
A. Ntemka ◽  
A. Makedou ◽  
E. Moralidis ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Rate Estimation ◽  
Glomerular Filtration Rate Estimation

Combined creatinine-cystatin C CKD-EPI equation significantly underestimates measured glomerular filtration rate in people with type 2 diabetes mellitus

2018 ◽  
Vol 53 ◽  
pp. 43-48 ◽  
Author(s):  
Júlia Dauernheimer Machado ◽  
Eduardo Guimarães Camargo ◽  
Roberta Boff ◽  
Laís da Silva Rodrigues ◽  
Joíza Lins Camargo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Measured Glomerular Filtration Rate

scholarly journals Use of Serum Cystatin C to Detect Early Decline of Glomerular Filtration Rate in Type 2 Diabetes

2007 ◽  
Vol 46 (12) ◽  
pp. 801-806 ◽  
Author(s):  
Yi-Sun Yang ◽  
Chiung-Huei Peng ◽  
Chih-Kuang Lin ◽  
Chi-Pin Wang ◽  
Chien-Ning Huang
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals CYSTATIN C AS A MARKER OF KIDNEY FUNCTION IN PATIENTS WITH DIABETES MELLITUS AND PURINE METABOLISM DISORDERS

2021 ◽  
Vol 21 (2) ◽  
pp. 87-92
Author(s):  
A. Chernyaeva ◽  
M. Mykytyuk
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate

Chronic kidney disease is a pressing issue for healthcare systems over the world; its prevalence has reached 13% in Western countries. In recent years, cystatin C has been proposed as a more reliable endogenous marker of renal function, especially for the diagnosis of initial changes in glomerular filtration rate. The aim of this study is to analyze the signs of chronic kidney disease in patients with type 2 diabetes mellitus depending on the level of uricemia by using cystatin C in real clinical practice. The study included 127 patients with type 2 diabetes mellitus (mean age = 60.0 years [52.0; 66.0]; sex ratio: 55 men/ 72 women) who received oral hypoglycemic therapy. All subjects, depending on the stage of diabetic nephropathy were divided into groups: group 1 (n=80) included patients with asymptomatic diabetic nephropathy (normoalbuminuria below 30 mg/day)); group 2 (n=22) involved patients with microalbuminuria (30-300 mg/day); group 3 (n=17) included patients with proteinuria; group 4 (n=8) comprised patients with chronic renal failure. Glomerular filtration rate was calculated according to the formulas of Chronic Kidney Disease Epidemiology Collaboration taking into account the concentration of cystatin C (Chronic Kidney Disease Epidemiology Collaboration cys), by Cockcroft-Gault and Modification of Diet in Renal Disease Study using a calculator of the National Institute of Diabetes and Digestive and Kidney Diseases. In patients with type 2 diabetes mellitus, the development of chronic kidney disease is also predetermined by the following comorbid conditions as hypertension, chronic pyelonephritis, hyperuricemia, and asymptomatic urolithiasis, along with diabetic nephropathy. Glomerular filtration rate values in patients with type 2 diabetes mellitus assessed by Chronic Kidney Disease Epidemiology Collaboration cys are more reliable than those assessed by using the formulas of Cockcroft-Gault and Modification of Diet in Renal Disease Study, especially at the limit level of glomerular filtration rate ˂60 ml/min/1.73m2. In patients with type 2 diabetes mellitus, the level of circulating cystatin C is associated with body mass index, waist circumference, blood uric acid concentration and albuminuria levels. The blood concentration of cystatin C in the patients with type 2 diabetes mellitus is determined by the blood concentration of creatine and uric acid.

scholarly journals Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes

Diabetologia ◽  
2009 ◽  
Vol 52 (7) ◽  
pp. 1274-1278 ◽  
Author(s):  
R. A. Chudleigh ◽  
R. L. Ollerton ◽  
G. Dunseath ◽  
R. Peter ◽  
J. N. Harvey ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate

STUDY OF RADIATION CHARACTERISTICS THE RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2014 ◽  
pp. 73-77
Author(s):  
Van Chuong Nguyen ◽  
Thi Kim Anh Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Disease Duration ◽  
Left Kidney ◽  
Cross Sectional ◽  
The Right

Background: A Research glomerular filtration rate (GFR) of 61 patients with type 2 diabetes mellitus with renal scanning 99mTc-DTPA glomerular filtration rate at the hospital 175. Objective: (1) To study characteristics of imaging of renal function. (2) Understanding the relationship between GFR with blood sugar, HbA1c, blood pressure and albuminuria in patients with type 2 diabetes. Methods: Descriptive, prospective, cross-sectional study. Clinical examination, Clinical tests and 99mTc-DTPA GFR gamma - camera renography for patients. Result: GFR of the study group was 75,4 ± 22,3 ml/phut/1,73m2, the left kidney was 35,0 ± 13,0 is lower than the right kidney and 39,8 ± 11,9; p <0,01. There is no correlation between GFR with blood glucose and HbA1c, the risk of reduced GFR in hypertensive group associated is OR = 6,5 with p<0,01; albuminuria (+) is OR = 4,2 with p <0,01; and disease duration > 10 years is OR = 3,5 with p <0.01. Conclusion: GFR of the left kidneys is lower than the right kidney; correlation decreased GFR associated with hypertension, albuminuria and disease duration. Keywords: GFR, diabetes, albuminuria

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