HbA1c and fasting plasma glucose cannot replace oral glucose tolerance test in order to screen for hyperglycemia in pregnancy

2021 ◽  
Author(s):  
Charlotte Nachtergaele ◽  
Eric Vicaut ◽  
Hélène Bihan ◽  
Sara Pinto ◽  
Meriem Sal ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Fasting Plasma ◽  
In Pregnancy

scholarly journals Sensitivity of postnatal fasting plasma glucose in identifying impaired glucose tolerance in women with gestational diabetes – 25 Years’ data

2017 ◽  
Vol 10 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Habiba Kapaya ◽  
Lucy May ◽  
Richard Jacques ◽  
Priya Madhuvrata
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Impaired Glucose Tolerance ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Fasting Plasma

Objective To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance. Methods Retrospective study of 1961 women diagnosed with gestational diabetes mellitus. All women were offered oral glucose tolerance test six weeks post-delivery. Results Of 1961 women, 1090 (56%) returned for postpartum oral glucose tolerance test. A fasting plasma glucose of ≥6.1 mmol/l identified only 76 of 167 women with impaired glucose tolerance detected by a 2-h oral glucose tolerance test (sensitivity of 45.5%; 95%CI: 38.1–53.1). We observed a normal fasting glucose but an impaired 2-h glucose tolerance in 91 out of 968 (9.4%) women. Asian ethnicity, admission on special care baby unit and antenatal insulin therapy strongly predicted 2-h impaired postnatal blood glucose levels (P < 0.05). Conclusion Although fasting plasma glucose is a convenient method, it lacks sensitivity in identifying women with impaired glucose tolerance postnatally.

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