scholarly journals Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile

2021 ◽  
Author(s):  
Adrian H. Heald ◽  
Susan Martin ◽  
Helene Fachim ◽  
Harry D. Green ◽  
Katherine G. Young ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Profile ◽  
Clinical Course ◽  
Meaningful Difference

scholarly journals Renal outcomes and clinical course of nondiabetic renal diseases in patients with type 2 diabetes

2013 ◽  
Vol 28 (5) ◽  
pp. 565 ◽  
Author(s):  
Ja Min Byun ◽  
Cheol Hyun Lee ◽  
Sul Ra Lee ◽  
Ju Young Moon ◽  
Sang Ho Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Course ◽  
Renal Diseases ◽  
Renal Outcomes

scholarly journals Differential effects of sodium-glucose cotransporter 2 inhibitor and low-carbohydrate diet on body composition and metabolic profile in obese diabetic db/db mice

2020 ◽  
Vol 8 (1) ◽  
pp. e001303
Author(s):  
Toru Kusakabe ◽  
Shigefumi Yokota ◽  
Mika Shimizu ◽  
Takayuki Inoue ◽  
Masashi Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Composition ◽  
Metabolic Profile ◽  
The Body ◽  
Carbohydrate Diet ◽  
Glucose Levels ◽  
Low Carbohydrate Diet ◽  
Sodium Glucose Cotransporter ◽  
Low Carbohydrate

IntroductionTreatment using sodium-glucose cotransporter (SGLT) 2 inhibitor and low-carbohydrate diet (LCD) for obesity and type 2 diabetes are similar in terms of carbohydrate limitation. However, their mechanisms of action differ, and the effects on the body remain unclear. We investigated the effects of SGLT2 inhibitor and LCD on body composition and metabolic profile using the db/db mouse model for obesity and type 2 diabetes.Research design and methodsEight-week-old male db/db mice were divided into four groups: mice receiving normal diet and vehicle or canagliflozin (Cana) administration and mice receiving LCD and vehicle or Cana administration for 8 weeks. Consumed calories were adjusted to be equal among the groups.ResultsBoth Cana administration and LCD feeding resulted in significant weight gain. Cana administration significantly decreased plasma glucose levels and increased plasma insulin levels with preservation of pancreatic β cells. However, LCD feeding did not improve plasma glucose levels but deteriorated insulin sensitivity. LCD feeding significantly reduced liver weight and hepatic triglyceride content; these effects were not observed with Cana administration. Combined treatment with LCD did not lead to an additive increase in blood β-ketone levels.ConclusionsSGLT2 inhibitors and LCD exert differential effects on the body. Their combined use may achieve better metabolic improvements in obesity and type 2 diabetes.

Administration of Herbarium Mixture (Guazuma ulmifolia/Tecoma stans) on Metabolic Profile in Type 2 Diabetes Mellitus Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

2020 ◽  
Author(s):  
Sara Pascoe-González ◽  
María Guadalupe Ramos-Zavala ◽  
Miguel Angel Buenrostro Ahued ◽  
Sandra Ofelia Hernández-González ◽  
Ernesto Germán Cardona-Muñoz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Profile ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Guazuma Ulmifolia

Clinico-metabolic profile of a group of women with type 2 diabetes with high doses of insulin

2018 ◽  
Vol 275 ◽  
pp. e199-e200
Author(s):  
C. Jemai ◽  
N. Ben Amor ◽  
M. Zarrouk ◽  
H. Tertek ◽  
A. Temessek ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Profile ◽  
High Doses
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