A comparison between point‐of‐care testing and venous glucose determination for the diagnosis of diabetes mellitus 6–12 weeks after gestational diabetes

2019 ◽  
Vol 36 (5) ◽  
pp. 591-599 ◽  
Author(s):  
A. Coetzee ◽  
M. Vyver ◽  
M. Hoffmann ◽  
D. R. Hall ◽  
D. Mason ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Glucose Determination ◽  
Diagnosis Of Diabetes Mellitus ◽  
Venous Glucose

scholarly journals Diagnosis of Gestational Diabetes Mellitus with Point-of-Care Methods for Glucose versus Hospital Laboratory Method Using Isotope Dilution Gas Chromatography-Mass Spectrometry as Reference

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Karl Kristensen ◽  
Anne-Marie Wangel ◽  
Anastasia Katsarou ◽  
Nael Shaat ◽  
David Simmons ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Point Of Care ◽  
Gas Chromatography Mass Spectrometry ◽  
Positive Bias ◽  
Altman Analysis ◽  
Bland Altman Analysis

Background. In Sweden, both glucose analyzers in accredited laboratories and point-of-care glucose devices are used for gestational diabetes mellitus (GDM) diagnosis. The aim of this study was to compare the diagnostic performance of the HemoCue Glucose 201+ (HC201+) and RT (HC201RT) systems with that of the hospital central laboratory hexokinase method (CL) based on lyophilized citrate tubes, using the isotope dilution gas chromatography-mass spectrometry (ID GC-MS) as reference. Methods. A 75 g oral glucose tolerance test was performed on 135 women screened positive for GDM. Diagnosis was based on the World Health Organization 2013 diagnostic thresholds for fasting (n=135), 1 h (n=52), and 2 h (n=135) glucose measurements. Bland-Altman analysis and surveillance error grids were used to evaluate analytical and clinical accuracy. Results. Significantly more women were diagnosed with GDM by HC201+ (80%) and CL (80%) than with the reference (65%, P<0.001) based on fasting and/or 2 h thresholds, whereas the percentage diagnosed by HC201RT (60%) did not differ significantly from the reference. In Bland-Altman analysis, a positive bias was observed for HC201+ (4.2%) and CL (6.1%) and a negative bias for HC201RT (−1.8%). In the surveillance error grid, 95.9% of the HC201+ values were in the no-risk zone as compared to 98.1% for HC201RT and 97.5% for CL. Conclusions. A substantial positive bias was found for CL measurements resulting in overdiagnosis of GDM. Our findings suggest better performance of HC201RT than HC201+ in GDM diagnosis. The results may have possible implications for GDM diagnosis in Sweden and require further elucidation.

The value of hemoglobin A1c for diagnosis of diabetes mellitus and other changes in carbohydrate metabolism in women with recent gestational diabetes mellitus

2012 ◽  
Vol 59 (6) ◽  
pp. 362-366
Author(s):  
Luis García de Guadiana Romualdo ◽  
Mercedes González Morales ◽  
M. Dolores Albaladejo Otón ◽  
Elena Martín García ◽  
M. del Carmen Martín-Ondarza González ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Hemoglobin A1c ◽  
Diagnosis Of Diabetes Mellitus

scholarly journals Multicenter assessment of a hemoglobin A1c point-of-care device for diagnosis of diabetes mellitus

2018 ◽  
Vol 61 ◽  
pp. 18-22 ◽  
Author(s):  
Philip M. Sobolesky ◽  
Breland E. Smith ◽  
Amy K. Saenger ◽  
Karen Schulz ◽  
Fred S. Apple ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hemoglobin A1c ◽  
Point Of Care ◽  
Diagnosis Of Diabetes Mellitus

scholarly journals A Prospective Evaluation of Point-of-Care Measurements of Maternal Glucose for the Diagnosis of Gestational Diabetes Mellitus

2020 ◽  
Vol 66 (2) ◽  
pp. 316-323 ◽  
Author(s):  
Eimer G O’Malley ◽  
Ciara M E Reynolds ◽  
Ruth O’Kelly ◽  
Anne Killalea ◽  
Sharon R Sheehan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Regression Analysis ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Plasma Glucose ◽  
Point Of Care ◽  
Oral Glucose ◽  
Regression Equations ◽  
Capillary Glucose ◽  
Maternal Glucose

Abstract Background Point-of-care (POC) measurement of glucose is currently recommended only for the monitoring of gestational diabetes mellitus (GDM). This prospective observational study evaluated the use of POC measurements of maternal glucose to diagnose GDM in women being screened selectively with a 1-step 75 g oral glucose tolerance test (OGTT). Methods The strictest preanalytic and analytic international laboratory standards were applied to measure maternal plasma glucose at fasting and at 1 and 2 h post glucose load. The recent International Association of Diabetes and Pregnancy Study Groups diagnostic criteria were used. At the same time, maternal capillary glucose was measured. Because of differences in plasma and capillary glucose measurements, regression analysis of POC capillary glucose results vs laboratory plasma glucose results was conducted. The regression equations for plasma glucose were derived in a derivation cohort (n = 102). These equations were applied in the validation cohort (n = 100). Predicted and actual plasma glucose values were compared. Results Of the 202 women screened, 36.6% were nulliparous, 56.4% were obese, and 81.2% were Irish-born. Two thirds had a single risk factor for GDM, and a third had multiple risk factors. Based on the plasma measurements, 53.5% had GDM. As a predictor of GDM, the diagnostic accuracy of POC measurement was 83.0% (95% confidence interval, 74.2–89.8). Conclusions In high-resource settings where measures to inhibit glycolysis are implemented, the use of POC measurements for the diagnosis of GDM is not justified based on this study. In low- and medium-resource settings, where measures to inhibit glycolysis are not achievable, regression analysis using POC measurements may be acceptable compared with plasma samples subject to glycolysis.

Point-of-Care Testing device for analysis of Diabetes Mellitus

2013 ◽  
Author(s):  
J. A. Oliveira ◽  
G. Minas ◽  
M. Correia-Neves ◽  
J. Mariz ◽  
C. Capela ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Point Of Care ◽  
Testing Device ◽  
Point Of Care Testing

scholarly journals Self-administered oral glucose tolerance test with capillary glucose measurements for the screening of diabetes mellitus in high-risk adults: a feasibility study

2021 ◽  
Vol 9 (2) ◽  
pp. e002556
Author(s):  
Andrew Yen Siong Tan ◽  
Mui Suan Tan ◽  
Ashley Wu ◽  
Ai Choo Seah ◽  
Cecilia Chong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Capillary Glucose ◽  
Venous Glucose

IntroductionEarly diagnosis of prediabetes based on blood sampling for the oral glucose tolerance test (OGTT) is crucial for intervention but multiple barriers hinder its uptake. This study aimed to assess the feasibility and precision of a self-administered capillary OGTT for type-2 diabetes mellitus (T2DM) in high-risk individuals.Research design and methodsParticipants with history of gestational diabetes or prediabetes were recruited in primary care. Due to their prediabetic status and previous diagnosis of gestational diabetes mellitus, a proportion of participants had previous experience doing OGTT. They self-administered the capillary OGTT and concurrently their venous glucose samples were obtained. They filled a questionnaire to collect their demographic information, views of their capillary OGTT, and their preferred site of the test.ResultsAmong 30 participants enrolled in this feasibility study, 93.3% of them felt confident of performing the capillary OGTT themselves, and 70.0% preferred the test at home. Older, less educated participants found it less acceptable. Mean capillary glucose values were significantly higher than venous glucose values, with mean difference at 0.31 mmol/L (95% CI 0.13 to 0.49) at fasting, and 0.47 mmol/L (95% CI 0.12 to 0.92) 2 hours post-OGTT. Capillary and venous glucose measurements were correlated for fasting (r=0.95; p<0.001) and 2-hour-post-OGTT (r=0.95;p<0.001). The Fleiss-Kappa Score (0.79, p<0.0001) indicated fair agreement between the two methods. The capillary OGTT had excellent sensitivity (94.1%) and negative predictive value (NPV=91.7%) in identifying prediabetes or T2DM status, vis-a-vis to venous glucose samples.ConclusionSelf-administered capillary OGTT is feasible and acceptable, especially among younger adults, with excellent sensitivity and NPV compared with plasma-based OGTT.

Blood glucose measurement for the diagnosis of diabetes mellitus: new and controversial consequences of updated DDG (German Diabetes Society)- and AWMF (Association of the Scientific Medical Societies)-guidelines1)

2013 ◽  
Vol 36 (2) ◽  
Author(s):  
Theodor Koschinsky ◽  
Peter B. Luppa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Blood Glucose Measurement ◽  
Glucose Measurement ◽  
Medical Societies ◽  
German Diabetes ◽  
Diagnosis Of Diabetes Mellitus

AbstractNew DDG (Deutsche Diabetes-Gesellschaft) and AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften) guidelines have been established for the diagnosis of diabetes mellitus and gestational diabetes. These are relevant for blood glucose (BG) measurements with reference to: distinction from HbA

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