scholarly journals Predictors of early renal function decline in adults with Type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes and the Pittsburgh Epidemiology of Diabetes Complications studies

2017 ◽  
Vol 34 (11) ◽  
pp. 1532-1540 ◽  
Author(s):  
P. Bjornstad ◽  
T. Costacou ◽  
R. G. Miller ◽  
D. M. Maahs ◽  
M. J. Rewers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Diabetes Complications ◽  
Renal Function Decline

scholarly journals Impaired Renal Function Further Increases Odds of 6-Year Coronary Artery Calcification Progression in Adults With Type 1 Diabetes

Diabetes Care ◽  
2013 ◽  
Vol 36 (9) ◽  
pp. 2607-2614 ◽  
Author(s):  
David M. Maahs ◽  
Diana Jalal ◽  
Michel Chonchol ◽  
Richard J. Johnson ◽  
Marian Rewers ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Impaired Renal Function

The role of mineral and bone metabolism disorders in the development and progression of cardiac and renal pathology in the patients presenting with long-lasting type 1 diabetes mellitus

2013 ◽  
Vol 59 (5) ◽  
pp. 16-24
Author(s):  
M S Biragova ◽  
S A Gracheva ◽  
A M Glazunova ◽  
T I Dubrovskaia ◽  
S A Martynov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Renal Function ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Calcium Metabolism ◽  
Agatston Score ◽  
Cardiovascular Pathology ◽  
Score Index

The present study included a total of 96 patients with long-lasting type 1 diabetes mellitus (DM1) and early (0-5) stages of chronic renal disease (CRD). Replacement renal therapy (RRT) consisted of programmed hemodialysis (PHD) and kidney transplantation (KT). Routine clinical examination was supplemented by the assessment of phosphorous and calcium metabolism indices, measurement of cardiac pathology markers, and studies of coronary artery calcification with the use of multispiral computed tomography (MSCT) of the heart with the calculation of the Agatston score index. It was shown that the impairment of the renal function was accompanied by a rise in the phosphorus, parathormone, and FGF-23 levels, increased vitamin D deficiency (with a slight deviation of its levels from the reference values in the patients at high risk of cardiovascular events treated with PHD). In the patients who had undergone KT and showed fairly good function of the renal transplant, the above parameters were similar to those of the patients with stage 0-4 CRD which suggested their normalization in case of adequate RRT during DM1. The progress of cardiovascular pathology with the deterioration of the renal function was manifested as an increase of NT-proBNP levels in parallel to the duration of CRD (r=0.304; p<0.05), decrease of the glomerular filtration rate (p=-0.540; p<0.05), and their significant correlation with the main characteristics of mineral homeostasis. The degree of coronary artery calcification was related to the patients' age, duration of DM1, and severity of arterial hypertension. The high Agatston score index and pronounced left ventricular hypertrophy in the patients following KT are supposed to reflect the irreversible character of certain cardiovascular lesions persisting despite optimal RRT and positive dynamics of phosphorus and calcium metabolism and NT-proBNP levels. It is concluded that the development and progression of renal dysfunction are associated with the disturbances of mineral and bone metabolism that promote further progress of cardiovascular pathology that is the main cause of mortality among this cohort of patients.

Progression of Coronary Artery Calcification Is Associated with Clinically Relevant Cognitive Impairment in Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1473-P
Author(s):  
JINGCHUAN GUO ◽  
KAREN NUNLEY ◽  
CATERINA ROSANO ◽  
TREVOR J. ORCHARD
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Coronary Artery ◽  
Coronary Artery Calcification

scholarly journals Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Maria Beatriz Monteiro ◽  
Tatiana S. Pelaes ◽  
Daniele P. Santos-Bezerra ◽  
Karina Thieme ◽  
Antonio M. Lerario ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Longitudinal Data ◽  
Urinary Sediment ◽  
Renal Function Decline

scholarly journals The role of coronary artery calcification testing in incident coronary artery disease risk prediction in type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 259-268 ◽  
Author(s):  
Jingchuan Guo ◽  
Sebhat A. Erqou ◽  
Rachel G. Miller ◽  
Daniel Edmundowicz ◽  
Trevor J. Orchard ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Risk Prediction ◽  
Coronary Artery Calcification ◽  
Disease Risk ◽  
Coronary Artery Disease Risk ◽  
Artery Disease

scholarly journals Skin Fluorescence Correlates Strongly with Coronary Artery Calcification Severity in Type 1 Diabetes

2010 ◽  
Vol 12 (5) ◽  
pp. 339-345 ◽  
Author(s):  
Baqiyyah Conway ◽  
Daniel Edmundowicz ◽  
Nathaniel Matter ◽  
John Maynard ◽  
Trevor Orchard
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Skin Fluorescence
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