Late effects of childhood cancer treatment: severe hypertriglyceridaemia, central obesity, non alcoholic fatty liver disease and diabetes as complications of childhood total body irradiation

2013 ◽  
Vol 30 (8) ◽  
pp. e239-e242 ◽  
Author(s):  
R. Rajendran ◽  
E. Abu ◽  
A. Fadl ◽  
C. D. Byrne
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Cancer Treatment ◽  
Total Body Irradiation ◽  
Late Effects ◽  
Fatty Liver Disease ◽  
Central Obesity ◽  
Alcoholic Fatty Liver ◽  
Total Body ◽  
Alcoholic Fatty Liver Disease

scholarly journals Correlation of Gut Firmicutes/Bacteroidetes Ratio with Fibrosis and Steatosis in Patients with Non-alcoholic Fatty Liver Disease

2020 ◽  
Author(s):  
Chyntia Olivia Maurine Jasirwan ◽  
Akhmadu Muradi ◽  
Irsan Hasan ◽  
Marcellus Simadibrata ◽  
Ikhwan Rinaldi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Central Obesity ◽  
Gastrointestinal Microbiota ◽  
Alcoholic Fatty Liver ◽  
Microbiota Diversity ◽  
Alcoholic Fatty Liver Disease ◽  
High Triglyceride

Abstract Background : We investigated the gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) and its correlation with fibrosis and steatosis as reflected in the controlled attenuation parameter and transient elastography valuesMethods : A cross-sectional study was performed on 37 patients with NAFLD at Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. The gut microbiota was investigated in fecal samples with 16S RNA sequencing using the next-generation sequencing platform MiSeq (Illumina).Results : NAFLD was more common in patients with metabolic syndrome. Firmicutes, Bacteroidetes, and Proteobacteria were the predominant phyla. Bacteroides was more dominant than Prevotella, contrary to the results in previous studies on normal populations in Indonesia. Microbiota dysbiosis was observed in most samples. The gastrointestinal microbiota diversity was significantly decreased in patients with NAFLD with high triglyceride levels and central obesity. The Firmicutes/Bacteroidetes ratio correlated with steatosis and obesity, whereas some other species in the lower taxonomy were mostly correlated with steatosis and obesity without fibrosis. Proteobacteria is the only phylum strongly correlated with fibrosis in patients with normal body mass index.Conclusions : The gut microbiota diversity was decreased in patients with NAFLD with high triglyceride levels and central obesity, and certain gut microbes were correlated with fibrosis and steatosis.

scholarly journals The Association between Interleukin-6 and Mean Platelet Volume Levels in Central Obesity with or without Non-Alcoholic Fatty Liver Disease

2020 ◽  
Vol 21 (3) ◽  
pp. 193-198
Author(s):  
Linda Rotty ◽  
Nelly Tendean ◽  
Nancy Lestari ◽  
Randy Adiwinata
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Interleukin 6 ◽  
Mean Platelet Volume ◽  
Fatty Liver Disease ◽  
Central Obesity ◽  
Platelet Volume ◽  
Alcoholic Fatty Liver ◽  
Sample Group ◽  
Alcoholic Fatty Liver Disease

Background: Obesity had become a global problem today. Obesity is a significant risk factor of cardiovascular and other metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). It remains unclear if the increased mean platelet volume (MPV) at the steatosis state is practicable as early detection of the occurrence of fatty liver in individuals with central obesity. This study aims to determine the association of interleukin-6 (IL-6) and MPV levels in central obesity with or without NAFLD.Method: This study was descriptive-analytic with a cross-sectional approach conducted in Prof. dr. R. D. Kandou Manado general hospital from May to July 2018. Consecutive sampling was performed based on inclusion criteria, then IL-6, MPV, and abdominal ultrasound examinations were performed.Results: This study included 40 samples of men with central obesity, 28 people (70%) among them were diagnosed with NAFLD. The Fisher exact test showed an association between NAFLD and an increase in IL-6 (p = 0.039), also between MPV and NAFLD (p=0.015). Pearson correlation test showed there was no significant correlation between IL-6 and MPV in the NAFLD sample group (p = 0.084; r -0.332) and in the non-NAFLD sample group (p = 0.564; r -0.186).Conclusion: Elevated MPV and IL-6 values may be used as marker for NAFLD presence among central obesity patients.

scholarly journals Gambaran NAFLD pada Pasien dengan Sindrom Metabolik di Poliklinik Penyakit Dalam RSUP Dr. M. Djamil Padang

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Nadila Andam Astari ◽  
Eva Decroli ◽  
Eti Yerizel
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Blood Sugar ◽  
Fatty Liver Disease ◽  
Central Obesity ◽  
Fasting Blood Sugar ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

AbstrakSindrom metabolik adalah kumpulan faktor risiko penyakit kardiovaskular yang terjadi secara bersamaan pada seorang individu, antara lain: peningkatan glukosa darah puasa, obesitas sentral, dislipidemia, dan hipertensi. Salah satu manifestasi sindrom metabolik adalah non alcoholic fatty liver disease (NAFLD). Tujuan penelitian ini adalah untuk mengetahui gambaran NAFLD pada pasien dengan sindrom metabolik di poliklinik penyakit dalam RSUP Dr. M. Djamil Padang. Penelitian ini bersifat deskriptif dengan bentuk cross sectional dan pendekatan retrospektif menggunakan data primer berupa hasil USG hati dan lingkar perut serta data sekunder berupa data rekam medis hasil pemeriksaan tekanan darah dan lab darah (gula darah, kolesterol, dan trigliserida) pasien dengan sindrom metabolik di RSUP Dr. M. Djamil Padang periode Oktober 2013 – Agustus 2014. Dari 30 subjek yang didapatkan, didapatkan 20 diantaranya menderita NAFLD (67%). Dari 20 orang penderita NAFLD, 20 orang (100%) obesitas sentral, 19 orang (95%) menderita gula darah puasa terganggu, 13 orang (65%) mengalami peningkatan trigliserida darah, 13 orang (65%) mengalami penurunan kadar HDL darah, dan 15 orang (75%) hipertensi.Kata kunci: sindrom metabolik, NAFLD, obesitas AbstractMetabolic syndrome is a set of cardiovascular disease risk factors that occur simultaneously on an individual, i.e. increase in fasting blood sugar, central obesity, dyslipidemia, and hypertension. Non alcoholic fatty liver disease (NAFLD) is one of the manifestations of metabolic syndrome. The objective of this study was to determine description of NAFLD on patients with metabolic syndrome at internal medicine polyclinic RSUP. Dr. M. Djamil Padang. Descriptive research has been conducted with a cross-sectional study and a retrospective approach using liver USG result and waist circumference as primary data and medical record of blood pressure and lab (triglyceride, HDL, fasting blood sugar) as secondary data on patients with metabolic syndrome at RSUP Dr. M. Djamil Padang during October 2013 – August 2014. The result of this study showed 20 cases of NAFLD (67%) from 30 subjects found. From those 20 cases, 20 have central obesity (100%), 19 have impaired fasting blood sugar (95%), 13 have hypertriglyceridemia (65%), 13 have decrease of blood HDL level (65%), and 15 have hypertension (75%).Keywords: metabolic syndrome, NAFLD, obesity

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

2008 ◽  
Vol 78 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Suano de Souza ◽  
Silverio Amancio ◽  
Saccardo Sarni ◽  
Sacchi Pitta ◽  
Fernandes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Fatty Liver Disease ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

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