scholarly journals Pharmacological and neurosurgical interventions for individuals with cerebral palsy and dystonia: a systematic review update and meta‐analysis

2021 ◽  
Author(s):  
Emma Bohn ◽  
Katherine Goren ◽  
Lauren Switzer ◽  
Yngve Falck‐Ytter ◽  
Darcy Fehlings
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Meta Analysis

scholarly journals The efficacy of functional gait training in children and young adults with cerebral palsy: a systematic review and meta-analysis

2018 ◽  
Vol 60 (9) ◽  
pp. 866-883 ◽  
Author(s):  
Adam T C Booth ◽  
Annemieke I Buizer ◽  
Pieter Meyns ◽  
Irene L B Oude Lansink ◽  
Frans Steenbrink ◽  
...  
Keyword(s):  
Systematic Review ◽  
Young Adults ◽  
Cerebral Palsy ◽  
Meta Analysis ◽  
Gait Training ◽  
Children And Young Adults ◽  
Functional Gait

Oral health in children with cerebral palsy: A systematic review and meta‐analysis

2020 ◽  
Vol 40 (5) ◽  
pp. 401-411
Author(s):  
Caterina Bensi ◽  
Micaela Costacurta ◽  
Raffaella Docimo
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Oral Health ◽  
Meta Analysis ◽  
Children With Cerebral Palsy

scholarly journals Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Tono Djuwantono ◽  
Jenifer Kiem Aviani ◽  
Wiryawan Permadi ◽  
Tri Hanggono Achmad ◽  
Danny Halim
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Intellectual Disability ◽  
Assisted Reproductive Technology ◽  
Risk Ratio ◽  
Neurodevelopmental Disorders ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Reproductive Technology ◽  
Multiple Birth

Abstract Background Various techniques in assisted reproductive technology (ART) have been developed as solutions for specific infertility problems. It is important to gain consensual conclusions on the actual risks of neurodevelopmental disorders among children who are born from ART. This study aimed to quantify the relative risks of cerebral palsy, intellectual disability, autism spectrum disorder (ASD), and behavioral problems in children from different ART methods by using systematic review and meta-analysis. Healthcare providers could use the results of this study to suggest the suitable ART technique and plan optimum postnatal care. Methods Pubmed, Google Scholar, and Scopus databases were used to search for studies up to January 2020. Of the 181 screened full manuscripts, 17 studies (9.39%) fulfilled the selection criteria. Based on the Newcastle-Ottawa scale ratings, 7 studies were excluded, resulting in 10 studies that were eventually included in the meta-analyses. Mantel-Haenszel risk ratio model was used in the meta-analysis, and the results are described using forest plot with 95% confidence interval. Heterogeneity was assessed using the I2 value. Results Pooled evaluation of 10 studies showed that the risk of cerebral palsy in children from assisted reproductive technology (ART) is higher than children from natural conceptions (risk ratio [RR] 1.82, [1.41, 2.34]; P = 0.00001). Risk of intellectual disability (RR 1.46, [1.03, 2.08]; P = 0.03) and ASD (RR 1.49 [1.05, 2.11]; P = 0.03) are higher in intracytoplasmic sperm injection (ICSI) children compared to conventional in vitro fertilization (IVF) children. The differences in the risk of neurodevelopmental disorders in children born after frozen and fresh embryo transfers are not significant. Analysis on potential cofounder effects, including multiple birth, preterm birth, and low birth body weight highlight possibilities of significant correlation to the risks of neurodevelopmental disorders. Conclusions Pooled estimates suggest that children born after ART are at higher risk of acquiring cerebral palsy. ICSI treatment causes higher risk of intellectual disability and ASD. These findings suggest the importance of the availability of intensive care unit at the time of delivery and long-term developmental evaluation particularly in children from ICSI.

scholarly journals Neurological disorders in autism: A systematic review and meta-analysis

Autism ◽  
2020 ◽  
pp. 136236132095137 ◽  
Author(s):  
Pei-Yin Pan ◽  
Sven Bölte ◽  
Preet Kaur ◽  
Sadia Jamil ◽  
Ulf Jonsson
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Nervous System ◽  
Cerebral Palsy ◽  
General Population ◽  
Neurological Disorders ◽  
Migraine Headache ◽  
Meta Analysis ◽  
Full Range ◽  
Neurological Complications

The etiological significance of neurological disorders in autism is debated, but it is clear that they complicate support provision and clinical management, and can have negative impact on outcomes. This systematic review and meta-analysis explored the full range of co-occurring neurological disorders in autism. We estimated the odds of having neurological complications compared to the general population and other neurodevelopmental conditions, as well as the overall prevalence of different neurological disorders. Seventy-nine articles were eligible for the systematic review, including 28 case-control studies, 43 prevalence studies, and 8 cohort studies. Findings were heterogeneous across studies. Overall, autistic individuals were significantly more likely than the general population to exhibit epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headache, and congenital abnormalities of the nervous system, with prevalence estimates ranging from 1.1% (0%–3.3%; hydrocephalus) to 14.2% (11.3%–17.2%; epilepsy). Epilepsy was also more common in autism than in attention-deficit/hyperactivity disorder (odds ratio [95% confidence interval] = 4.06 [2.81–5.88]). Findings indicate that awareness of neurological disorders and neurological check-ups are indicated in autism to ensure adequate physical health care and support. Prospective studies of neurological disorders in children diagnosed with or at risk of autism might further enhance our understanding of causal pathways. Lay abstract Neurological disorders, such as epilepsy and cerebral palsy, have been reported to occur among individuals with autism beyond chance and may have an impact on daily living across the lifespan. Although there has been research investigating neurological disorders in autism, the findings are not always conclusive. Previous summaries of existing studies have not evaluated the full range of neurological disorders. This study aimed to comprehensively explore the neurological problems appearing in autism to provide updated information that is needed for better healthcare and support in this population. We looked at already published studies focusing on risk or frequency of neurological disorders in autism. Our results suggest that individuals with autism are more likely than the general population to have a range of neurological disorders, including epilepsy, macrocephaly, hydrocephalus, cerebral palsy, migraine/headache, and inborn abnormalities of the nervous system. In order to provide individualized healthcare and support of high quality to individuals diagnosed with autism, health care professionals and other support providers need to be attentive to neurological complications. To further improve our understanding about the link between autism and neurological disorders, future research should follow the neurological health of children who are diagnosed with or are at increased likelihood of autism.

Prognostic predictors for ambulation in children with cerebral palsy: a systematic review and meta-analysis of observational studies

2016 ◽  
Vol 40 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Orawan Keeratisiroj ◽  
Nuanlaor Thawinchai ◽  
Wantana Siritaratiwat ◽  
Montana Buntragulpoontawee ◽  
Chayanin Pratoomsoot
Keyword(s):  
Systematic Review ◽  
Cerebral Palsy ◽  
Observational Studies ◽  
Meta Analysis ◽  
Prognostic Predictors ◽  
Children With Cerebral Palsy
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