Neurocognitive and behavioural profile in Panayiotopoulos syndrome

2019 ◽  
Vol 62 (8) ◽  
pp. 985-992 ◽  
Author(s):  
Eric L A Fonseca Wald ◽  
Mariette H J A Debeij‐Van Hall ◽  
Eline De Jong ◽  
Albert P Aldenkamp ◽  
R Jeroen Vermeulen ◽  
...  
Author(s):  
Chiara Toschi ◽  
Mona El-Sayed Hervig ◽  
Parisa Moazen ◽  
Maximilian G. Parker ◽  
Jeffrey W. Dalley ◽  
...  

Abstract Background Work in humans has shown that impulsivity can be advantageous in certain settings. However, evidence for so-called functional impulsivity is lacking in experimental animals. Aims This study investigated the contexts in which high impulsive (HI) rats show an advantage in performance compared with mid- (MI) and low impulsive (LI) rats. We also assessed the effects of dopaminergic and noradrenergic agents to investigate underlying neurotransmitter mechanisms. Methods We tested rats on a variable inter-trial interval (ITI) version of the 5-choice serial reaction time task (5CSRTT). Rats received systemic injections of methylphenidate (MPH, 1 mg/kg and 3 mg/kg), atomoxetine (ATO, 0.3 mg/kg and 1 mg/kg), amphetamine (AMPH, 0.2 mg/kg), the alpha-2a adrenoceptor antagonist atipamezole (ATI, 0.3 mg/kg) and the alpha-1 adrenoceptor agonist phenylephrine (PHEN, 1 mg/kg) prior to behavioural testing. Results Unlike LI rats, HI rats exhibited superior performance, earning more reinforcers, on short ITI trials, when the task required rapid responding. MPH, AMPH and ATI improved performance on short ITI trials and increased impulsivity in long ITI trials, recapitulating the behavioural profile of HI. In contrast, ATO and PHEN impaired performance on short ITI trials and decreased impulsivity, thus mimicking the behavioural profile of LI rats. The effects of ATO were greater on MI rats and LI rats. Conclusions These findings indicate that impulsivity can be advantageous when rapid focusing and actions are required, an effect that may depend on increased dopamine neurotransmission. Conversely, activation of the noradrenergic system, with ATO and PHEN, led to a general inhibition of responding.


BMJ ◽  
2002 ◽  
Vol 324 (7348) ◽  
pp. 1228-1229 ◽  
Author(s):  
M. Koutroumanidis

2018 ◽  
Vol 41 (2) ◽  
pp. 185-214 ◽  
Author(s):  
Vittorio TANTUCCI

Abstract This article combines research results centred on theory of mind (ToM) from cognitive and developmental psychology (Goldman 2006; Apperly 2010; Wilkinson and Ball 2012) with the notion of intersubjectivity in usage-based linguistics (i.a. Verhagen 2005; Nuyts 2012; Traugott 2012). It identifies some of the controversies in the literature from both domains and suggests the desiderata for a hybrid approach to intersubjectivity, which is distinctively designed to tackle applied research in social and cognitive sciences. This model is based on a mismatch between interaction as mere ‘co-action’ vs. interaction as spontaneously communicated awareness of an(other) mind(s). It provides a case study centred on the first language acquisition of pre-nominal usage of this/that and such. From, respectively, a distinctive collexeme (Gries and Stefanowitsch 2004) and behavioural profile analysis (Gries 2010) will emerge that beyond expressions of joint attention, children’s ToM ability progressively underpins ‘ad-hoc’ generalized instantiations based on extended intersubjectivity, viz. the socio-cognitive skill to problematize what a general persona would act, feel, or think in a specific context.


2018 ◽  
Vol 10 (4) ◽  
pp. 361-380 ◽  
Author(s):  
Patricia Viveiros de Castro Krakauer ◽  
Gustavo Hermínio Salati Marcondes de Moraes ◽  
Roberto Coda ◽  
Davi de França Berne

Purpose The paper aims to investigate the existence of typical preferred behaviours that might characterize Brazilian women’s entrepreneurial profile and whether this profile influences their motivation to undertake a venture. Design/methodology/approach Following the evolution of the literature on women entrepreneurship, the study criticizes the rational view that conceives entrepreneurship as a universal phenomenon and immune to gender. A quantitative approach based on multivariate data analysis (structural equation modelling) was applied to a sample of 418 women entrepreneurs with regard to six hypotheses associated with a specifically conceived conceptual model. Findings The behavioural categories tested in the model that most influence Brazilian women’s entrepreneurial profile are planning, identifying opportunities, sociability and leadership, corroborating the results of other international studies. Behaviours connected with persistence did not correlate to Brazilian women’s entrepreneurial profile. The hypothesis that women’s entrepreneurial profile positively influences their entrepreneurial intention was confirmed. Research limitations/implications As the study is based on an intentional, non-probabilistic sample, further research needs to be conducted using other forms of sampling, extending the findings to other contexts internationally and to other Brazilian regions. Practical implications Women can perceive whether their behavioural profile is suited to embracing entrepreneurship challenges, helping them to make effective career choices. Originality/value The study provides a robust model with high explanatory value. It contributes to the women’s entrepreneurship literature from the perspective of a Latin American developing country, offering valuable insights regarding the impact of entrepreneurial behavioural profile on women’s entrepreneurial activities.


2017 ◽  
Vol 173 (10) ◽  
pp. 2753-2757
Author(s):  
Paolo Bonanni ◽  
Susanna Casellato ◽  
Franco Fabbro ◽  
Susanna Negrin

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