scholarly journals Cardiovascular disease and other childhood‐onset chronic conditions in adults with cerebral palsy

2018 ◽  
Vol 61 (8) ◽  
pp. 859-860
Author(s):  
Jeffrey D Edwards
Keyword(s):  
Cardiovascular Disease ◽  
Cerebral Palsy ◽  
Chronic Conditions ◽  
Childhood Onset

Trends in Technology Assistance Among Patients With Childhood Onset Chronic Conditions

2021 ◽  
Vol 11 (7) ◽  
pp. 711-719
Author(s):  
Elizabeth F. Boggs ◽  
Carolyn Foster ◽  
Parag Shah ◽  
Denise M. Goodman ◽  
Matthew Hall ◽  
...  
Keyword(s):  
Chronic Conditions ◽  
Childhood Onset ◽  
Technology Assistance

scholarly journals Hereditary spastic paraplegia associated with a rare endoplasmic reticulum lipid raft-associated protein 2 mutation

2020 ◽  
Vol 7 (10) ◽  
pp. 2077
Author(s):  
Sai Chandar Dudipala ◽  
Naveen Reddy Cheruku ◽  
Krishna Chaithanya Battu
Keyword(s):  
Endoplasmic Reticulum ◽  
Cerebral Palsy ◽  
Lipid Raft ◽  
Hereditary Spastic Paraplegia ◽  
Autosomal Recessive ◽  
Adult Population ◽  
Complex Form ◽  
Spastic Paraplegia ◽  
Childhood Onset ◽  
Exonic Deletion

Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of neurological disorders that are characterized by progressive spasticity of the lower extremities. It can present as pure form or complex form. It can be present from infancy to adulthood, but majority in adult population. Childhood onset HSP must be differentiated from common conditions like cerebral palsy, neurodegenerative disorders and metabolic disorders. Many patients with pediatric HSP are mistakenly diagnosed with cerebral palsy. In children with spastic paraplegia in whom no acquired cause identified, HSP should be considered. Here we diagnosed a 6-year-old boy with HSP who presented with progressive spastic paraplegia, intellectual disability, seizures, joint contractures and cataract. His genetic study revealed exonic deletion of endoplasmic reticulum lipid raft-associated protein gene, which is associated with complicated Autosomal recessive HSP 18 (SPG18). HSP 18 was rarely described in literature.

scholarly journals Low‐Trauma Fracture Increases 12‐Month Incidence of Cardiovascular Disease for Adults With Cerebral Palsy

2019 ◽  
Vol 38 (4) ◽  
pp. 803-810 ◽  
Author(s):  
Daniel G. Whitney ◽  
Rachael T. Whitney ◽  
Rhonda D. Prisby ◽  
Karl J. Jepsen
Keyword(s):  
Cardiovascular Disease ◽  
Cerebral Palsy ◽  
Low Trauma Fracture

Health-related quality of life in children with heart failure as perceived by children and parents

2015 ◽  
Vol 26 (5) ◽  
pp. 885-893 ◽  
Author(s):  
Ivan Wilmot ◽  
Constance E. Cephus ◽  
Amy Cassedy ◽  
Ian Kudel ◽  
Bradley S. Marino ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Cardiovascular Disease ◽  
Chronic Conditions ◽  
Healthy Children ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Children With Chronic Conditions

Advancements in paediatric heart failure management have resulted in improved survival and a focus on long-term outcomes including health-related quality of life. We compared health-related quality of life in children with heart failure with healthy patients, children with chronic conditions, and children with cardiovascular disease.Families (n=63) and children (n=73) aged 2–20 years with heart failure were enrolled and compared with data previously published for healthy patients (n=5480), those with chronic conditions (n=247), and those with cardiovascular disease (n=347). Patients and parents completed the PedsQL 4.0 and the Cardiac 3.0 Module health-related quality-of-life questionnaires. PedsQL scores including Total, Psychosocial Health Summary, and Physical were compared between groups. In general, patients with heart failure had lower scores than the healthy population (p=0.001), and comparable scores with those with chronic conditions. Parents perceived no difference in physical scores for children with heart failure when compared with healthy children, and perceived higher scores for children with heart failure when compared with those with chronic conditions (p⩽0.003). Furthermore, children with heart failure had decremental health-related quality-of-life scores as the American Heart Association stage of heart failure increased, such that patients with stage C heart failure had scores similar to children with severe cardiovascular disease.Children with heart failure reported significantly impaired health-related quality of life compared with healthy children and similar scores compared with children with chronic conditions. Parental perceptions appear to underestimate these impairments. Children with heart failure appear to have progressive impairment of health-related quality of life with advancing stage of heart failure.

scholarly journals Treating Restless Legs Syndrome Was Associated With Low Risk of Cardiovascular Disease: A Cohort Study With 3.4 Years of Follow‐Up

2021 ◽  
Vol 10 (4) ◽  
Author(s):  
Xiang Gao ◽  
Djibril M. Ba ◽  
Kanika Bagai ◽  
Guodong Liu ◽  
Chaoran Ma ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Treatment Group ◽  
Restless Legs Syndrome ◽  
Chronic Conditions ◽  
Medication Use ◽  
Cvd Risk ◽  
Restless Legs ◽  
Age And Sex

Background Restless legs syndrome (RLS) is associated with higher cardiovascular disease (CVD) risk. However, it remains unknown whether treatment of RLS lowers the cardiovascular risk associated with RLS. Methods and Results All data were collected retrospectively, but subjects were prospectively followed forward in time to determine outcomes of interest. We used the Truven Health MarketScan Commercial Claims and Encounters database from January 1, 2006, through December 31, 2014. Participants were 169 393 individuals, which included 24 199 nonpregnant participants with an RLS diagnosis (16 694 receiving treatments for RLS and 7505 without treatment) during 2006 to 2008 and 145 194 age‐ and sex‐matched participants without RLS. All participants were free of CVD before January 1, 2009 (analysis baseline). Incident CVD cases (myocardial infarction, angina, stroke, atrial fibrillation, and heart failure) were identified. We adjusted for potential confounders, such as presence of chronic conditions and medication use. We identified 16 574 incident CVD cases during 2009 to 2014. Relative to the non‐RLS group, the adjusted hazard ratio (HR) for future CVD was 1.26 (95% CI, 1.20–1.32) ( P <0.001) for the RLS with treatment group, and 1.53 (95% CI, 1.42–1.65) ( P <0.001) for the RLS without treatment group. Significant lower CVD risk was observed for all different RLS treatments, including dopaminergics, anticonvulsants, benzodiazepines, and opiates (adjusted HRs range, 0.71‐0.84; P <0.001 for all), except for ergot‐dopamine use. Conclusions RLS was associated with higher future CVD risk. However, RLS was associated with statistically significantly less future cardiovascular risk in RLS patients with treatment than in those without treatment.

scholarly journals Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-Associated Hereditary Spastic Paraplegia

2021 ◽  
Vol 7 (4) ◽  
pp. e605
Author(s):  
Catherine Jordan ◽  
Gregory Geisel ◽  
Julian E. Alecu ◽  
Bo Zhang ◽  
Mustafa Sahin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cerebral Palsy ◽  
Hereditary Spastic Paraplegia ◽  
Motor Impairment ◽  
Health Related Quality ◽  
Spastic Paraplegia ◽  
Childhood Onset ◽  
Related Quality ◽  
Health Related

ObjectiveAP-4-associated hereditary spastic paraplegia (AP-4-HSP) is a childhood-onset neurogenetic disease and mimic of cerebral palsy. Data on health-related quality of life (HRQoL) are lacking. To establish a metric for HRQoL and caregiver priorities, we used the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) questionnaire to assess HRQoL in correlation with disease severity in 64 patients with AP-4-HSP.MethodsA cross-sectional analysis of caregiver-reported HRQoL was performed using the CPCHILD questionnaire in combination with a detailed clinical characterization.ResultsHRQoL was impaired in all domains in patients with AP-4-HSP (mean score: 59.6 ± 12.6 [SD]), with no significant difference between the 4 subtypes. Age, as a surrogate for disease duration, and Spastic Paraplegia Rating Scale scores, as an indicator for corticospinal tract dysfunction and motor impairment, correlated with lower CPCHILD scores (Pearson r = −0.31, p = 0.01 and r = −0.52, p < 0.0001, respectively). Patients with tetraplegia showed lower CPCHILD scores compared with individuals with diplegia or no spasticity. Wheelchair dependence reduced HRQoL in all domains. The presence of seizures, including medically refractory epilepsy, was not associated with lower CPCHILD scores. Standardized assessment of caregiver priorities identified several areas of high importance to HRQoL.ConclusionsWe show that the CPCHILD questionnaire, developed for use in children with cerebral palsy, can be used to assess HRQoL in patients with childhood-onset complex hereditary spastic paraplegia. HRQoL is reduced in patients with AP-4-HSP and correlates with the degree of motor impairment. These results provide a framework for medical decision making and a baseline for the future development of treatment guidelines and interventional trials.

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