scholarly journals Retinal nerve fibre layer thinning is associated with worse visual outcome after optic neuritis in children with a relapsing demyelinating syndrome

2018 ◽  
Vol 60 (12) ◽  
pp. 1244-1250 ◽  
Author(s):  
Michael Eyre ◽  
Aasim Hameed ◽  
Sukhvir Wright ◽  
Wallace Brownlee ◽  
Olga Ciccarelli ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Nerve Fibre ◽  
Visual Outcome ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Is retinal nerve fibre layer thickness correlated with visual function in individuals having optic neuritis?

2021 ◽  
pp. 1-7
Author(s):  
Abbas Ali Yekta ◽  
Sara Sorouh ◽  
Amir Asharlous ◽  
Ali Mirzajani ◽  
Ebrahim Jafarzadehpur ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Correlation of Peripapillary Retinal Nerve Fibre Layer Thickness and Visual Evoked Potential in Optic Neuritis in a Tertiary Eye Care Centre

2019 ◽  
Vol 10 (2) ◽  
pp. 156-161
Author(s):  
Manita Sunam Godar ◽  
Ananda Kumar Sharma ◽  
Madhu Thapa ◽  
Sanjeeta Sitaula ◽  
Nita Sunam Gamal ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Retinal Nerve Fibre Layer ◽  
P Value ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Introduction: Optic neuritis (ON) is the involvement of the optic nerve as a result of inflammation, demyelination or infection. Objective: To study the correlation between peripapillary retinal nerve fibre layer thickness (pRNFL) and visual evoked potential (VEP) in ON cases. Materials and Method: A non-interventional, descriptive, cross sectional study enrolling 66 eyes of 49 patients with ON was done. pRNFL thickness was measured by Optical Coherence Tomography (OCT) and VEP was also done. OCT and VEP findings were compared with the control group. In addition correlation between pRNFL thickness and VEP was done. Results: The mean pRNFL in affected eyes were significantly higher than the control superiorly (p-value<0.001), inferiorly (p-value <0.001), temporally (p-value 0.005) and nasally (p-value <0.001). The mean P100 latency in the affected eyes were significantly prolonged than the control eyes both at 1º (p-value<0.001) and at 15’ (p-value=0.05). The mean N75-P100 amplitude in the affected eyes were significantly reduced than the control eyes both at 1º (p-value<0.001) and at 15’ (p-value<0.001). The mean pRNFL thickness in all four quadrants and VEP findings of the affected eyes showed no significant correlation. Conclusion: The increased thickness in non-myelinated pRNFL has no correlation with the increased latency or decreased amplitude in cases of ON. However, OCT is seen as a useful tool in detecting and quantifying even subtle pRNFL changes in cases of optic neuritis.

Degeneration of retinal layers in multiple sclerosis subtypes quantified by optical coherence tomography

2012 ◽  
Vol 18 (10) ◽  
pp. 1422-1429 ◽  
Author(s):  
P Albrecht ◽  
M Ringelstein ◽  
AK Müller ◽  
N Keser ◽  
T Dietlein ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Primary Progressive ◽  
Retinal Layers ◽  
Fibre Layer ◽  
History Of ◽  
Nerve Fibre Layer

Background: Optical coherence tomography can be used to assess retinal degeneration in multiple sclerosis (MS). Thinning of the retinal nerve fibre layer and macular thickness have been well characterized, but newer devices allow quantification of all retinal layers. Objectives: The objective of this study was to evaluate the thickness of the paramacular retina, peripapillary retinal nerve fibre layer, and deeper paramacular layers in MS patient subgroups, using state-of-the-art optical coherence tomography. Methods: Using a Heidelberg Engineering Spectralis device, we performed paramacular volumetric retinal scans and circular peripapillary fibre-layer scans, manually segmenting different retinal layers into single horizontal foveal scans in 95 patients with definite MS (42 relapsing–remitting, 41 secondary progressive, 12 primary progressive), plus 91 age- and sex-matched controls. Results: Even without a history of optic neuritis, all MS subgroups had significant thinning of the peripapillary retinal nerve fibre layer, the paramacular retinal thickness and the retinal ganglion cell- and inner plexiform layer. Only in primary progressive MS was the inner nuclear layer significantly reduced. Conclusions: Our findings indicate a primary retinal pathology involving the inner nuclear layer in primary progressive MS. Results in eyes without history of optic neuritis suggest possible subclinical episodes of optic neuritis or retrograde trans-synaptic degeneration of retinal ganglion cells and their axons.

scholarly journals Retinal Nerve Fibre Layer Thinning in Patients with Clinically Isolated Optic Neuritis and Early Treatment with Interferon-Beta

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51645 ◽  
Author(s):  
Kurt-Wolfram Sühs ◽  
Katharina Hein ◽  
Jens R. Pehlke ◽  
Barbara Käsmann-Kellner ◽  
Ricarda Diem
Keyword(s):  
Optic Neuritis ◽  
Nerve Fibre ◽  
Early Treatment ◽  
Interferon Beta ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Longitudinal Changes in Retinal Nerve Fibre Layer Thickness after an Isolated Unilateral Retrobulbar Optic Neuritis: 1-Year Results

2015 ◽  
Vol 39 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Gordon S. K. Yau ◽  
Jacky W. Y. Lee ◽  
Patrick P. K. Lau ◽  
Victor T. Y. Tam ◽  
Winnie W. Y. Wong ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Longitudinal Changes ◽  
Fibre Layer ◽  
Retrobulbar Optic Neuritis ◽  
Nerve Fibre Layer

scholarly journals Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

2017 ◽  
Vol 96 (3) ◽  
pp. e309-e314 ◽  
Author(s):  
Tereza Svrčinová ◽  
Jan Mareš ◽  
Oldřich Chrapek ◽  
Irena Šínová ◽  
Martina Rybariková ◽  
...  
Keyword(s):  
Pilot Study ◽  
Optic Neuritis ◽  
Oxygen Saturation ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer
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