scholarly journals High sensitivity and specificity in proposed clinical diagnostic criteria for anti-N -methyl-D -aspartate receptor encephalitis

2017 ◽  
Vol 59 (12) ◽  
pp. 1256-1260 ◽  
Author(s):  
Alvin C C Ho ◽  
Shekeeb S Mohammad ◽  
Sekhar C Pillai ◽  
Esther Tantsis ◽  
Hannah Jones ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Sensitivity And Specificity ◽  
High Sensitivity ◽  
Aspartate Receptor ◽  
Clinical Diagnostic ◽  
Clinical Diagnostic Criteria

scholarly journals Neuropathological validation of the MDS-PSP criteria with PSP and other frontotemporal lobar degeneration

2019 ◽  
Author(s):  
Stefano Gazzina ◽  
Gesine Respondek ◽  
Yaroslau Compta ◽  
Kieren S.J. Allinson ◽  
Maria G. Spillantini ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Diagnostic Criteria ◽  
Sensitivity And Specificity ◽  
Frontotemporal Lobar Degeneration ◽  
Corticobasal Degeneration ◽  
Primary Progressive Aphasia ◽  
Clinical Diagnostic ◽  
Novel Therapeutic Strategies ◽  
Richardson’S Syndrome ◽  
Clinical Diagnostic Criteria

ABSTRACTBackgroundProgressive supranuclear palsy (PSP) is clinically heterogeneous. Clinical diagnostic criteria were revised in 2017, to increase sensitivity and operationalize the diagnosis of PSP Richardson’s syndrome (PSP-RS) and “variant” syndromes (vPSP).ObjectivesTo determine the (1) sensitivity and specificity of the 1996 NINDS-SPSP and 2017 MDS-PSP criteria; (2) false positive rates in frontotemporal dementia with frontotemporal lobar degeneration (FTLD); and (3) clinical evolution of variant PSP syndromes (vPSP).MethodsRetrospective multicenter review of 108 neuropathologically-confirmed PSP patients and 81 patients with other forms of FTLD: 38 behavioral variant frontotemporal dementia (bvFTD), 14 non-fluent/agrammatic variant primary progressive aphasia (nfvPPA), and 29 corticobasal degeneration (CBD), Sensitivity and specificity of the MDS-PSP criteria were compared to the NINDS-SPSP criteria at baseline. In a subset of cases, the timing and frequency of clinical features were compared across groups over six years.ResultsSensitivity for recognition of probable and possible PSP pathology was higher by MDS-PSP criteria (72.2-100%) than NINDS-SPSP criteria (48.1-61.1%). Specificity was higher by NINDS-SPSP criteria (97.5-100%) than MDS-PSP criteria (53.1-95.1%). False positives by MDS-PSP criteria were few for bvFTD (10.5-18.4%) but common for CBD and nfvPPA (fulfilling “suggestive of’ PSP). Most vPSP cases developed PSP-RS-like features within six years, including falls and supranuclear gaze palsy, distinguishing frontal presentations of PSP from bvFTD, and speech/language presentations of PSP from nfvPPA.ConclusionsThe 2017 MDS-PSP criteria successfully identify PSP, including variant phenotypes. This independent validation of the revised clinical diagnostic criteria strengthens the case for novel therapeutic strategies against PSP to include variant presentations.

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