scholarly journals Clinical clues for autoimmunity and neuroinflammation in patients with autistic regression

2017 ◽  
Vol 59 (9) ◽  
pp. 947-951 ◽  
Author(s):  
Ori Scott ◽  
Diya Shi ◽  
Diana Andriashek ◽  
Brenda Clark ◽  
Helly R Goez
Keyword(s):  
Autistic Regression

scholarly journals A.02 Clinical clues for autoimmunity in the etiology of autistic regression

2016 ◽  
Vol 43 (S2) ◽  
pp. S7-S7
Author(s):  
H Goez ◽  
O Scott ◽  
D Shi ◽  
D Andriashek ◽  
B Clark
Keyword(s):  
Autoimmune Thyroiditis ◽  
Febrile Illness ◽  
Autism Spectrum ◽  
Diagnostic Interview ◽  
Type I ◽  
Perinatal Complications ◽  
Autoimmune Conditions ◽  
History Of ◽  
Autistic Regression ◽  
Immune Changes

Background: Autistic regression (AR) accounts for 20-40% of patients with Autism Spectrum Disorder (ASD) .1 Literature demonstrates specific immune changes in AR patients,2 as well as association between AR and autoimmune thyroiditis.3 Our study explores the clinical association between AR and autoimmunity, focusing on possible precipitants and familial autoimmunity, in comparison with patients with infantile autism (IA). Methods: charts of children diagnosed with ASD in 2014 were reviewed, and patients were classified as either AR or IA based on Autism Diagnostic Interview (ADI-R) criteria.4 Information regarding pregnancy, perinatal complications, febrile illness preceding the diagnosis, and family history of autoimmune conditions was collected. Results: 206 children had IA and 33 had AR. No difference was found in prevalence of pregnancy or perinatal complications. The incidence of febrile illness in the 6 months prior to diagnosis and the prevalence of familial autoimmunity, were significantly higher in the AR group (p<0.001). Diabetes type I, celiac disease, autoimmune thyroiditis, and inflammatory bowel disease were more common in families of AR patients (p<0.05). Conclusions: the association between AR and preceding febrile illness, as well as familial autoimmunity, supports the notion of AR as a separate entity within ASD, possibly mediated by autoimmune changes.

Autistic Regression in Relation to Limbic Pathology and Epilepsy: Report of Two Cases

2008 ◽  
Vol 35 (2) ◽  
pp. 166-176 ◽  
Author(s):  
Theirry Deonna ◽  
Anne-Lise Ziegler ◽  
Jaime Moura-Serra ◽  
Giorgio Innocenti
Keyword(s):  
Autistic Regression

GASTROINTESTINAL SYMPTOMS AND SEIZURES IN AUTISTIC REGRESSION.

2007 ◽  
Vol 55 (1) ◽  
pp. S82
Author(s):  
K. Angkustsiri ◽  
R. L. Hansen ◽  
S. Ozonoff ◽  
P. Krakowiak ◽  
C. Jones ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
Autistic Regression

scholarly journals Rate of Head Circumference Growth as a Function of Autism Diagnosis and History of Autistic Regression

2007 ◽  
Vol 22 (10) ◽  
pp. 1182-1190 ◽  
Author(s):  
Sara Jane Webb ◽  
Theresa Nalty ◽  
Jeff Munson ◽  
Catherine Brock ◽  
Robert Abbott ◽  
...  
Keyword(s):  
Head Circumference ◽  
Autism Diagnosis ◽  
History Of ◽  
Autistic Regression

Levetiracetam-Induced Reversible Autistic Regression

2012 ◽  
Vol 47 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Ana Camacho ◽  
José Carlos Espín ◽  
Noemí Nuñez ◽  
Rogelio Simón
Keyword(s):  
Autistic Regression

Sleep in children with autism with and without autistic regression

2010 ◽  
Vol 20 (2) ◽  
pp. 338-347 ◽  
Author(s):  
FLAVIA GIANNOTTI ◽  
FLAVIA CORTESI ◽  
ANTONELLA CERQUIGLINI ◽  
CRISTINA VAGNONI ◽  
DONATELLA VALENTE
Keyword(s):  
Children With Autism ◽  
Autistic Regression

scholarly journals N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Heba Hamed Elshahawi ◽  
Ghada Refaat Amin Taha ◽  
Hanan Mohamed Ezzeldin Azzam ◽  
Reem H. El Ghamry ◽  
Ahmed Adel Mohammad Abdelgawad ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Nmda Receptor ◽  
Autoimmune Encephalitis ◽  
Stereotyped Behavior ◽  
Autism Spectrum ◽  
Clinical Findings ◽  
Spectrum Disorder ◽  
Symptom Profile ◽  
Stereotyped Behaviors ◽  
Autistic Regression

Abstract Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like autistic regression. Thus, the purpose of the study was to test for the presence of anti-NMDAR antibodies in the ASD disorder population and to correlate this with the clinical findings. Results Eighty-seven autistic children, 4–12 years old, were enrolled in the study and were matched with sixty typically developing children used as controls. The diagnosis of cases was confirmed by ADOS-2 and clinical evaluation. None of the control children had positive anti-NMDAR antibodies, while 26.4% (23 children) of the patients’ group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was statistically correlated with better speech stage (p = 0.017), more severe stereotyped behavior (p ≤ 0.001), and abnormal EEG findings (p = 0.025). Conclusions There is a possibility of the presence of anti-NMDAR antibodies in the autism spectrum disorder population with certain characteristics, especially the severity of the stereotyped behaviors.

Language/Autistic Regression

2013 ◽  
pp. 1698-1698
Author(s):  
Moira Lewis ◽  
Courtenay Norbury ◽  
Rhiannon Luyster ◽  
Lauren Schmitt ◽  
Andrea McDuffie ◽  
...  
Keyword(s):  
Autistic Regression
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