scholarly journals Grey matter injury in cerebral palsy - pallidum for the role of the predicting severity

2015 ◽  
Vol 57 (12) ◽  
pp. 1089-1090 ◽  
Author(s):  
Ingeborg Krägeloh-Mann
2021 ◽  
Author(s):  
Prastiya Indra Gunawan ◽  
Riza Noviandi ◽  
Sunny Mariana Samosir

Abstract Background Cerebral palsy (CP) leads to a common static motor neurological disease in children that can be demonstrated with varied neuroimaging findings. Magnetic Resonance Imaging (MRI) has a vital role of determining the presence of brain injury and its extent, with any possibility of determining pathogenic pattern and disease severity. The objective of the study is to evaluate the neuroimaging findings in CP and their correlation to disease severity. Method The research was case-control study, consecutive and complete records of all patients who had a clinical diagnosis of CP and performed a head MRI between 2018 and 2019 were enrolled in this study. Cases group were children diagnosed as severe CP with The Gross Motor Function Classification System (GMFCS) IV-V. Control group were children confirmed as CP with GMFCS I-III. Brain imaging was examined by MRI, in which the abnormalities were classified into grey matter or white matter injury, focal vascular disorder and brain malformation. Kruskal-Wallis statistical analysis was applied to identify the correlation. Results Almost 60 cases were reviewed. White matter injury, malformation and focal vascular insult were not correlated significantly to CP severity (OR = 0.73; 95% CI = 0.2-2.2; p = 0.78 and OR = 0.61; 95% CI = 0.2-1.9; p = 0.57 and OR = 2.034; 95% CI = 0.51-0.76; p = 0.63, respectively). Grey matter injury was more frequent discovered in severe CP (50%) and increased the risk of CP severity (OR = 9; 95% CI = 2.2 – 36; p = 0.002). Conclusion Grey matter injury is considered the most frequent abnormalities of Brain MRI in CP and it could increase the risk of severity.


2022 ◽  
Vol 40 (1) ◽  
pp. 31-38
Author(s):  
Md Abdul Wahed ◽  
Md Altaf Hossain

Background: Cerebral Palsy is a non-progressive disorder due to insult in the developing brain. This causes disorders in muscle tone, posture and movement. Cerebral palsy is usually diagnosed by clinical features. Though risk factors are identified in about 75% of cases, the etiology remains unclear. Magnetic resonance imaging is the standard method to detect central nervous system abnormalities; but in resource poor areas CT Scanning may be an alternative method to elucidate the underlying Central Nervous System abnormalities. Objectives: The objective was to detect CT Scanning findings in different types of Cerebral palsies. Methodology: This was a prospective and cross-sectional study conducted on 525 Children registered at Child Development Center attached to Rangpur Mother and Children Hospital. Cerebral palsy was diagnosed by using an Interview Schedule. During from 1.1.2016 to 31.12.2019 CT scanning of brain was performed purposefully to all children to detect the underlying Central Nervous System abnormalities. The purpose was explained to parents and consent was taken before performing the tests. The children were in sedation during the procedure. Result: A total of 1800 registered children, 525 (29.10%) children were suffering from Cerebral Palsy. The male and female ratio was 3:2 and age distribution was 2.6±1.5 years. Seventy nine percent (79.0%) of children came from poor families. Parental education up to class V was in 65% cases. Maximum number (63.0%) of cases was suffering from spastic type of Cerebral Palsy followed by athetoid type (18.3%) and 7.1% ataxic type. Among spastics, quadriplegia was present in 68.5% of cases followed by hemiplegia (18.5%). Perinatal asphyxia was the commonest (56.1%) risk factor of Cerebral Palsy. Among all the CTs 116 (22.0%) were with normal finding and 409 (78.0%) were with various types of abnormal findings. White Matter Injury was present in 79 (15.0%) of cases and among these volume loss in periventricular areas with ventricular dilatation and deep white matter damage was common. The next abnormalities were Focal Vascular Insults (9.0%), Malformations (5.0%) and Unclassified lesions (4.0%). Grey Matter Injury was common in spastic type of cerebral palsy but there was much overlapping of abnormal findings and most (66.3%) insults occurred in perinatal period. Conclusion: CT scanning of brain is a comparable test to detect the central nervous system abnormalities in resource poor areas. Grey matter injury is the common abnormality in Cerebral palsy but there is much overlapping between CT Scanning findings and clinical diagnosis. J Bangladesh Coll Phys Surg 2022; 40: 31-38


2015 ◽  
Vol 57 (12) ◽  
pp. 1159-1167 ◽  
Author(s):  
Susan M Reid ◽  
Charuta D Dagia ◽  
Michael R Ditchfield ◽  
Dinah S Reddihough

2019 ◽  
Vol 4 (67) ◽  
pp. 180
Author(s):  
Adelina Staicu ◽  
Adela Hanga ◽  
Ioana C. Rotar ◽  
Gabriela C. Zaharie ◽  
Daniel Mureşan

2008 ◽  
Vol 12 ◽  
pp. S75
Author(s):  
G. Hnatyszyn ◽  
M.B. Czeszyńska ◽  
L. Cyryłowski ◽  
H. Konefał ◽  
O. Szmigiel ◽  
...  

2012 ◽  
Vol 321 (1-2) ◽  
pp. 111-113 ◽  
Author(s):  
Pratik Bhattacharya ◽  
Fen Bao ◽  
Megha Shah ◽  
Gautam Ramesh ◽  
Ramesh Madhavan ◽  
...  

PEDIATRICS ◽  
1960 ◽  
Vol 26 (4) ◽  
pp. 565-569
Author(s):  
William F. Windle

There is pressing need of well controlled clinical evaluation of the role of adverse factors in the prenatal, natal and early postnatal periods in the etiology of neurological disorders. This is particularly true of asphyxia neonatorum. Many articles have been written on relationships between apnea, anoxia or asphyxia and manifestations of mental retardation, cerebral palsy, epilepsy and othe neurological, psychological and behavioral defects. The majority of the writers express opinions, but give no evidence that data were collected. Controls are commonly lacking. Often no attempt to measure the variables appears to have been made. A review1 of more than 500 reports, commentaries and testimonials of clinical experiences reveals deficiency in basic information of physiology of the fetus and newborn that is nothing short of appalling.


Author(s):  
Paraskevi Theodorou ◽  
Athanasios Drigas

The purpose of this paper is to review the most representative studies of the last decade (2006-2015) which deal with the combination of technology and music and concern individuals with Generic learning disabilities. Particularly, the areas of needs in this paper are divided to the following categories: Depression/ disruptive behavior, Down syndrome, Intellectual disa¬bilities, Cerebral palsy and Severe/Profound disa-bilities. It is also underlined the important role of Information and Communication Technologies (ICTs) and digital music tools in promoting musical participation and as-sisting students with the pre-referred disa-bilities.


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