scholarly journals Intellectual disability: population-based estimates of the proportion attributable to maternal alcohol use disorder during pregnancy

2012 ◽  
Vol 55 (3) ◽  
pp. 271-277 ◽  
Author(s):  
COLLEEN O’LEARY ◽  
HELEN LEONARD ◽  
JENNY BOURKE ◽  
HEATHER D’ANTOINE ◽  
ANNE BARTU ◽  
...  
2021 ◽  
pp. 216770262110250
Author(s):  
Mallory E. Stephenson ◽  
Sara Larsson Lönn ◽  
Jessica E. Salvatore ◽  
Jan Sundquist ◽  
Kenneth S. Kendler ◽  
...  

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.


2016 ◽  
Vol 22 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Neomi van Duijvenbode ◽  
Robert Didden ◽  
Joanne EL VanDerNagel ◽  
Hubert PLM Korzilius ◽  
Rutger CME Engels

We examined cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability (MBID). Problematic drinkers were expected to show a significantly lower estimated performance IQ (PIQ), but not a lower estimated verbal IQ (VIQ), compared to light drinkers. Participants ( N = 474) were divided into four groups based on IQ and severity of alcohol use-related problems. IQ was estimated using (a short form of) the Wechsler Adult Intelligence Scale third edition. Severity of alcohol use-related problems was assessed using the Alcohol Use Disorder Identification Test. Overall, there were no significant differences between light and problematic drinkers on estimated VIQ. Within the group without MBID, estimated PIQ was significantly lower. Estimated PIQ was not lower in problematic drinkers with MBID compared to light drinkers with MBID. The results are indicative of cognitive deficits in problematic drinkers without MBID. Screening for cognitive deficits with additional instruments is advised.


PEDIATRICS ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. e20191574
Author(s):  
Colleen O’Leary ◽  
David Lawrence ◽  
Katherine Hafekost ◽  
Stephen R. Zubrick ◽  
Carol Bower

2017 ◽  
Vol 41 (8) ◽  
pp. 1452-1460 ◽  
Author(s):  
Katherine Hafekost ◽  
David Lawrence ◽  
Colleen O'Leary ◽  
Carol Bower ◽  
James Semmens ◽  
...  

Addiction ◽  
2017 ◽  
Vol 112 (4) ◽  
pp. 586-593 ◽  
Author(s):  
Jessica E. Salvatore ◽  
Sara Larsson Lönn ◽  
Jan Sundquist ◽  
Paul Lichtenstein ◽  
Kristina Sundquist ◽  
...  

2017 ◽  
Vol 174 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Sara Larsson Lönn ◽  
Jessica Salvatore ◽  
Jan Sundquist ◽  
Kristina Sundquist

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