Dynamics of transcriptional enhancers and chromosome topology in gene regulation

Moe Yokoshi; Takashi Fukaya

doi:10.1111/dgd.12597

Dynamics of transcriptional enhancers and chromosome topology in gene regulation

Development Growth & Differentiation ◽

10.1111/dgd.12597 ◽

2019 ◽

Vol 61 (5) ◽

pp. 343-352 ◽

Cited By ~ 4

Author(s):

Moe Yokoshi ◽

Takashi Fukaya

Keyword(s):

Gene Regulation ◽

Transcriptional Enhancers ◽

Chromosome Topology

Download Full-text

Nuclear receptors, transcriptional enhancers, and gene regulation

Endocrine Abstracts ◽

10.1530/endoabs.54.is3 ◽

2018 ◽

Author(s):

Hector L Franco ◽

Shino Murakami ◽

Tim Y Hou ◽

Yasmin M Vasquez ◽

Ziying Liu ◽

...

Keyword(s):

Gene Regulation ◽

Nuclear Receptors ◽

Transcriptional Enhancers

Download Full-text

The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

10.1101/2021.02.09.430385 ◽

2021 ◽

Author(s):

John Isaac Murray ◽

Elicia Preston ◽

Jeremy P. Crawford ◽

Jonathan D. Rumley ◽

Prativa Amom ◽

...

Keyword(s):

Gene Regulation ◽

Cell Division ◽

Hox Genes ◽

Hox Gene ◽

Animal Development ◽

C Elegans ◽

Transcriptional Enhancers ◽

Positional Identity ◽

Cell Position ◽

And Function

AbstractHox transcription factors play a conserved role in specifying positional identity during animal development, with posterior Hox genes typically repressing the expression of more anterior Hox genes. Here, we dissect the regulation of the posterior Hox genes nob-1 and php-3 in the nematode C. elegans. We show that nob-1 and php-3 are co-expressed in gastrulation-stage embryos in cells that express the anterior Hox gene ceh-13. This expression is controlled by several partially redundant transcriptional enhancers. Surprisingly, these enhancers require ceh-13 for expression, providing an example of an anterior Hox gene positively regulating a posterior Hox gene. Several other regulators also act positively through nob-1/php-3 enhancers, including elt-1/GATA, ceh-20/ceh-40/Pbx, unc-62/Meis, pop-1/TCF, ceh-36/Otx and unc-30/Pitx. We identified defects in both cell position and cell division patterns in ceh-13 and nob-1;php-3 mutants, suggesting that these factors regulate lineage identity in addition to positional identity. Together, our results highlight the complexity and remarkable flexibility of Hox gene regulation and function.

Download Full-text