scholarly journals Regulation of the neural niche by the soluble molecule Akhirin

2016 ◽  
Vol 58 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Uzzal Kumar Acharjee ◽  
Athary Abdulhaleem Felemban ◽  
Asrafuzzaman M. Riyadh ◽  
Kunimasa Ohta
Keyword(s):  
Soluble Molecule

scholarly journals A Review on Coordination Properties of Al(III) and Fe(III) toward Natural Antioxidant Molecules: Experimental and Theoretical Insights

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2603
Author(s):  
Luana Malacaria ◽  
Giuseppina Anna Corrente ◽  
Amerigo Beneduci ◽  
Emilia Furia ◽  
Tiziana Marino ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Natural Antioxidants ◽  
Point Of View ◽  
Water Soluble ◽  
Natural Antioxidant ◽  
Theoretical Point ◽  
Structure And Properties ◽  
Coordination Properties ◽  
Soluble Molecule ◽  
Living Organisms

This review focuses on the ability of some natural antioxidant molecules (i.e., hydroxycinnamic acids, coumarin-3-carboxylic acid, quercetin, luteolin and curcumin) to form Al(III)- and Fe(III)-complexes with the aim of evaluating the coordination properties from a combined experimental and theoretical point of view. Despite the contributions of previous studies on the chemical properties and biological activity of these metal complexes involving such natural antioxidants, further detailed relationships between the structure and properties are still required. In this context, the investigation on the coordination properties of Al(III) and Fe(III) toward these natural antioxidant molecules might deserve high interest to design water soluble molecule-based metal carriers that can improve the metal’s intake and/or its removal in living organisms.

scholarly journals The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments

2009 ◽  
Vol 419 (3) ◽  
pp. 661-668 ◽  
Author(s):  
Blandine Maître ◽  
Catherine Angénieux ◽  
Virginie Wurtz ◽  
Emilie Layre ◽  
Martine Gilleron ◽  
...  
Keyword(s):  
Amino Acids ◽  
Dendritic Cells ◽  
Amino Acid ◽  
Mammalian Species ◽  
Soluble Form ◽  
Β2 Microglobulin ◽  
Immature Dendritic Cells ◽  
Soluble Molecule ◽  
Α Chain ◽  
Acidic Compartments

CD1e displays unique features in comparison with other CD1 proteins. CD1e accumulates in Golgi compartments of immature dendritic cells and is transported directly to lysosomes, where it is cleaved into a soluble form. In these latter compartments, CD1e participates in the processing of glycolipid antigens. In the present study, we show that the N-terminal end of the membrane-associated molecule begins at amino acid 20, whereas the soluble molecule consists of amino acids 32–333. Thus immature CD1e includes an N-terminal propeptide which is cleaved in acidic compartments and so is absent from its mature endosomal form. Mutagenesis experiments demonstrated that the propeptide controls the assembly of the CD1e α-chain with β2-microglobulin, whereas propeptide-deleted CD1e molecules are immunologically active. Comparison of CD1e cDNAs from different mammalian species indicates that the CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species.

scholarly journals The control of diuresis in the tsetse fly Glossina austeni: a preliminary investigation of the diuretic hormone

1975 ◽  
Vol 63 (2) ◽  
pp. 391-401
Author(s):  
J. D. Gee
Keyword(s):  
Sialic Acid ◽  
Nervous Tissue ◽  
Preliminary Investigation ◽  
Tsetse Fly ◽  
Malpighian Tubules ◽  
Diuretic Hormone ◽  
Glossina Austeni ◽  
Heat Stable ◽  
Soluble Molecule ◽  
Degradative Enzyme

The rate of secretion of the Malpighian tubules of Glossina austeni is controlled by a diuretic hormone. This hormone is present in the nervous tissue of the fly together with a degradative enzyme that can be activated by boiling. It is demonstrated that the Malpighian tubules are able to destroy the diuretic hormone; they may therefore participate in the control of diuresis. The diuretic hormone appears to be a heat-stable, non-dialysable, alcohol-soluble molecule, containing amino acid, glucose and sialic acid residues.

scholarly journals Identification of soluble Fc receptors in mouse serum and the conditioned medium of stimulated B cells.

1984 ◽  
Vol 160 (6) ◽  
pp. 1836-1849 ◽  
Author(s):  
E Pure ◽  
C J Durie ◽  
C K Summerill ◽  
J C Unkeless
Keyword(s):  
B Cells ◽  
Normal Mouse ◽  
Culture Medium ◽  
Fold Increase ◽  
Mouse Serum ◽  
Spleen Cells ◽  
Germ Free ◽  
Murine Spleen ◽  
Soluble Molecule ◽  
Lps Activation

We have evaluated the expression of surface Fc gamma 2b/gamma 1R by lipopolysaccharide (LPS)-activated murine spleen cells, the release of soluble Fc gamma 2b/gamma 1R by activated spleen cells, and the presence of circulating Fc gamma 2b/gamma 1R in mouse serum. LPS activation of murine spleen cells and a cloned B cell line, BCL-1 CW 13.20-3B3, resulted in a 5-10-fold increase in surface Fc gamma 2b/gamma 1R and the concominant appearance in the culture medium of a soluble molecule that is antigenically related to the Fc gamma 2b/gamma 1R. The increase in cell-associated and soluble Fc gamma 2b/gamma 1R after LPS activation is attributable primarily to B cells. Circulating Fc gamma 2b/gamma 1R was also detected in normal mouse serum at a concentration of 10(-9) to 10(-8) M. Levels of circulating Fc gamma 2b/gamma 1R increase with the age of the animals, and were low in adult germ-free mice and elevated in young mice with certain autoimmune diseases. The circulating Fc gamma 2b/gamma 1R bound to IgG-Sepharose, and was partially purified by affinity chromatography on 2.4G2 Fab-Sepharose. After radiolabeling and immunoprecipitation with rabbit anti-Fc gamma 2b/gamma 1R serum, one component of Mr 48,000, was detected.

Expression in insect cells of the functional domain of CD21 (complement receptor type two) as a truncated soluble molecule using a baculovirus vector

1997 ◽  
Vol 38 (1-2) ◽  
pp. 141-148 ◽  
Author(s):  
Wolfgang M. Prodinger ◽  
Jürgen Schoch ◽  
Michael G. Schwendinger ◽  
Jens Hellwage ◽  
Walther Parson ◽  
...  
Keyword(s):  
Insect Cells ◽  
Receptor Type ◽  
Functional Domain ◽  
Complement Receptor ◽  
Baculovirus Vector ◽  
Complement Receptor Type ◽  
Soluble Molecule

scholarly journals Efficient and selective molecular catalyst for the CO2-to-CO electrochemical conversion in water

2015 ◽  
Vol 112 (22) ◽  
pp. 6882-6886 ◽  
Author(s):  
Cyrille Costentin ◽  
Marc Robert ◽  
Jean-Michel Savéant ◽  
Arnaud Tatin
Keyword(s):  
Carbon Monoxide ◽  
Carbonic Acid ◽  
Water Soluble ◽  
Turnover Frequency ◽  
High Turnover ◽  
Molecular Catalyst ◽  
Electrochemical Conversion ◽  
Production Of Hydrogen ◽  
Soluble Molecule ◽  
Neutral Water

Substitution of the four paraphenyl hydrogens of iron tetraphenylporphyrin by trimethylammonio groups provides a water-soluble molecule able to catalyze the electrochemical conversion of carbon dioxide into carbon monoxide. The reaction, performed in pH-neutral water, forms quasi-exclusively carbon monoxide with very little production of hydrogen, despite partial equilibration of CO2 with carbonic acid—a low pKa acid. This selective molecular catalyst is endowed with a good stability and a high turnover frequency. On this basis, prescribed composition of CO–H2 mixtures can be obtained by adjusting the pH of the solution, optionally adding an electroinactive buffer. The development of these strategies will be greatly facilitated by the fact that one operates in water. The same applies for the association of the cathode compartment with a proton-producing anode by means of a suitable separator.

scholarly journals The level of the soluble molecule of adhesion of vascular cells-1 and L-selectin in patients with antiphospholipid syndrome: a relationship with the disease activity, endothelial dysfunction and atherosclerosis

2013 ◽  
Vol 17 (2 (66)) ◽  
pp. 114-122
Author(s):  
Yu. S. Seheda ◽  
S. V. Shevchuk
Keyword(s):  
Antiphospholipid Syndrome ◽  
Vascular Endothelium ◽  
Antiphospholipid Antibodies ◽  
Elevated Concentration ◽  
Vascular Cells ◽  
Functional Changes ◽  
Tnf Α ◽  
Circulating Markers ◽  
Soluble Molecule ◽  
Healthy Persons

A significant increase of the indices of the molecule of adhesion of vascular cells-1 (sVCAM-1) and Lselectin was demonstrated in the course of the research in the blood of patients with antiphospholipid syndrome as compared with healthy persons. The levels of the substances under study were associated with the markers of the activity of an inflammatory process (ESR, TNF-α, IL-1, CRP), disturbances of the lipid metabolism, the presence of antiphospholipid antibodies and concomitant arterial hypertension, however, they practically did not depend on the age, gender, the duration of the disease, tobacco smoking, obesity and hypodynamia. Close correlations have also been established between an elevated concentration of sVCAM-1 and L-selectin and structural functional changes of the vascular endothelium, enabling to regard them to be circulating markers of an early development of atherosclerosis in patients with antiphospholipid syndrome.

Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection

2016 ◽  
Vol 512 (1) ◽  
pp. 137-146 ◽  
Author(s):  
Yin-Chao Tseng ◽  
Brian Linehan ◽  
Khing Jow Ng ◽  
Dustin M. Smith ◽  
Michael Markert ◽  
...  
Keyword(s):  
Cardiovascular Safety ◽  
Safety Pharmacology ◽  
Lead Selection ◽  
Poorly Soluble ◽  
Soluble Molecule ◽  
Spray Dried

Rationally developed core–shell polymeric-lipid hybrid nanoparticles as a delivery vehicle for cromolyn sodium: implications of lipid envelop on in vitro and in vivo behaviour of nanoparticles upon oral administration

RSC Advances ◽  
2015 ◽  
Vol 5 (93) ◽  
pp. 76491-76506 ◽  
Author(s):  
Ravi R. Patel ◽  
Gayasuddin Khan ◽  
Sundeep Chaurasia ◽  
Nagendra Kumar ◽  
Brahmeshwar Mishra
Keyword(s):  
Oral Administration ◽  
Oral Bioavailability ◽  
Water Soluble ◽  
Cromolyn Sodium ◽  
Hybrid Nanoparticles ◽  
Core Shell ◽  
Delivery Vehicle ◽  
Soluble Molecule

In the present study, cromolyn sodium, a highly water soluble molecule was encapsulated into rationally designed, core–shell polymeric-lipid hybrid nanoparticles for enhancing its oral bioavailability, by improving its intestinal permeability.

scholarly journals Novel soluble molecule, Akhirin, is expressed in the embryonic chick eyes and exhibits heterophilic cell-adhesion activity

2005 ◽  
Vol 233 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Mansoor Ahsan ◽  
Kunimasa Ohta ◽  
Sei Kuriyama ◽  
Hideaki Tanaka
Keyword(s):  
Cell Adhesion ◽  
Embryonic Chick ◽  
Soluble Molecule ◽  
Adhesion Activity
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