scholarly journals Antagonistic and synergistic effects of bone morphogenetic protein 2/7 and all-trans retinoic acid on the osteogenic differentiation of rat bone marrow stromal cells

2013 ◽  
Vol 55 (9) ◽  
pp. 744-754 ◽  
Author(s):  
Wenjuan Bi ◽  
Zhiyuan Gu ◽  
Yuanna Zheng ◽  
Limin Wang ◽  
Jing Guo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Synergistic Effects ◽  
Marrow Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Morphogenetic Protein ◽  
Rat Bone

Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7284-7300 ◽  
Author(s):  
Xiangfeng Li ◽  
Minjun Liu ◽  
Fuying Chen ◽  
Yuyi Wang ◽  
Menglu Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Natural Bone ◽  
Morphogenetic Protein ◽  
Bone Apatite

Biomimicking the nanostructure of natural bone apatite to enhance the bioactivity of hydroxyapatite (HA) biomaterials is an eternal topic in the bone regeneration field.

All-trans retinoic acid directly up-regulates thrombopoietin transcription in human bone marrow stromal cells

2004 ◽  
Vol 32 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Kentaro Kinjo ◽  
Yoshitaka Miyakawa ◽  
Hideo Uchida ◽  
Shigetaka Kitajima ◽  
Yasuo Ikeda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Retinoic Acid ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration

2019 ◽  
Vol 10 ◽  
pp. 204173141985270 ◽  
Author(s):  
Arooj Munir ◽  
Anne Døskeland ◽  
Steven J Avery ◽  
Tiziana Fuoco ◽  
Samih Mohamed-Ahmed ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Bone Morphogenetic Protein 2 ◽  
Matrix Group ◽  
Morphogenetic Protein ◽  
Collagen Type 1

Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied. A total of 390 proteins were identified by mass spectrometry. Bone regeneration proteins showed initial burst of release. Human bone marrow stromal cells were cultured on scaffolds physisorbed with 20 µg/mL and cultured in basal medium (DDM group) or physisorbed and cultured in osteogenic medium or cultured on non-functionalised scaffolds in osteogenic medium. The human bone marrow stromal cells proliferated less in demineralised dentine matrix group and activated ERK/1/2 after both time points. Cells on DDM group showed highest expression of IL-6 and IL-8 at 7 days and expressed higher collagen type 1 alpha 2, SPP1 and bone morphogenetic protein-2 until 21 days. Extracellular protein revealed higher collagen type 1 and bone morphogenetic protein-2 at 21 days in demineralised dentine matrix group. Cells on DDM group showed signs of mineralisation. The functionalised scaffolds were able to stimulate osteogenic differentiation of human bone marrow stromal cells.

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