scholarly journals The brain basis of handwriting deficits in Chinese children with developmental dyslexia

2021 ◽  
Author(s):  
Yang Yang ◽  
Zhentao Zuo ◽  
Fred Tam ◽  
Simon J. Graham ◽  
Junjun Li ◽  
...  
Keyword(s):  
Developmental Dyslexia ◽  
Chinese Children ◽  
The Brain

Altered topological organization of brain structural network in Chinese children with developmental dyslexia

2015 ◽  
Vol 589 ◽  
pp. 169-175 ◽  
Author(s):  
Kai Liu ◽  
Lin Shi ◽  
Feiyan Chen ◽  
Mary M.Y. Waye ◽  
Cadmon K.P. Lim ◽  
...  
Keyword(s):  
Developmental Dyslexia ◽  
Chinese Children ◽  
Structural Network ◽  
Topological Organization

scholarly journals The Influence of Articulatory Suppression on Reading Among Chinese Children with Developmental Dyslexia: An Eye-Movement and Case-Control Study

2020 ◽  
Author(s):  
Xiuhong Li ◽  
Weidong Li ◽  
Buyun Liu ◽  
Jinxin Zhang ◽  
Jingwen Ma ◽  
...  
Keyword(s):  
Eye Movement ◽  
Developmental Dyslexia ◽  
Reading Ability ◽  
High Speed ◽  
Articulatory Suppression ◽  
Reading Speed ◽  
Chinese Children ◽  
Phonological Loop ◽  
Eye Tracker ◽  
Core Deficit

Abstract Background: In Western countries, phonological processing deficit was regard as a core deficit in developmental dyslexia (DD). As Chinese is a logographic language, it’s still controversial whether and how the articulatory suppression influences reading ability and processing of Chinese children with DD. The study aimed to examine how the phonological loop influences reading ability and processing in Chinese children with DD.Methods: This study included 30 children with DD and 37 children without DD. Two types of articles (i.e., scenery prose and narrative story) and two conditions (under the conditions of articulatory-suppression and silent reading) were applied. An eye-link II High-Speed Eye Tracker was used to track a series of eye-movement parameters. The data was analyzed by the linear Mixed-Effects model. Results: Compared with children without DD, Children with DD had lower reading achievement (RA), frequency of saccades (FS) and frequency of fixations (FF), longer reading time (RT) and average fixation duration (AFD), slower reading speed (RS), shorter average saccade amplitude (ASA) and fixation distance (FD), more number of fixations (NF) and number of saccades (NS). There were significant interactions between participant group and articulatory suppression on RT and FD. We also observed interaction effects between article types and articulatory suppression on RA, AFD, ASA, and FS.Conclusion: Children DD exhibit abnormal phonological loop and eye movements while reading. The role of the articulatory suppression on reading varies with the presentation of DD and the article type.

scholarly journals Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia

2020 ◽  
Author(s):  
Andrea Bieder ◽  
Elisabet Einarsdottir ◽  
Hans Matsson ◽  
Harriet E. Nilsson ◽  
Jesper Eisfeldt ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Developmental Dyslexia ◽  
Situs Inversus ◽  
Rare Variants ◽  
Autosomal Recessive Disorder ◽  
Copy Number Variations ◽  
Single Nucleotide Variants ◽  
Dynein Arms ◽  
Left Right Asymmetry ◽  
The Brain

ABSTRACTBackgroundDevelopmental dyslexia (DD) is a neurodevelopmental learning disorder with high heritability. A number of candidate susceptibility genes have been identified, some of which are linked to the function of the cilium, an organelle regulating left-right asymmetry development in the embryo. Furthermore, it has been suggested that disrupted left-right asymmetry of the brain may play a role in neurodevelopmental disorders such as DD.MethodsHere, we studied two individuals with co-occurring situs inversus (SI) and DD using whole genome sequencing to identify single nucleotide variants or copy number variations of importance for DD and SI.ResultsIndividual 1 had primary ciliary dyskinesia (PCD), a rare, autosomal recessive disorder with oto-sino-pulmonary phenotype and SI. We identified two rare nonsynonymous variants in the dynein axonemal heavy chain 5 gene (DNAH5): c.7502G>C;p.(R2501P), a previously reported variant predicted to be damaging and c.12043T>G;p.(Y4015D), a novel variant predicted to be damaging. Ultrastructural analysis of the cilia revealed a lack of outer dynein arms and normal inner dynein arms. MRI of the brain revealed no significant abnormalities. Individual 2 had non-syndromic SI and DD. In individual 2, one rare variant (c.9110A>G;p.(H3037R)) in the dynein axonemal heavy chain 11 gene (DNAH11), coding for another component of the outer dynein arm, was identified.ConclusionsWe identified the likely genetic cause of SI and PCD in one individual, and a possibly significant heterozygosity in the other, both involving dynein genes. Given the present evidence, it is unclear if the identified variants also predispose to DD, but further studies into the association are warranted.

scholarly journals The Influence of Articulatory Suppression on Reading Among Chinese Children With Developmental Dyslexia: An Eye-Movement Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiuhong Li ◽  
Weidong Li ◽  
Buyun Liu ◽  
Jinxin Zhang ◽  
Jingwen Ma ◽  
...  
Keyword(s):  
Eye Movement ◽  
Developmental Dyslexia ◽  
Reading Ability ◽  
High Speed ◽  
Articulatory Suppression ◽  
Reading Speed ◽  
Chinese Children ◽  
Phonological Loop ◽  
Eye Tracker ◽  
Movement Parameters

Objective: The study aimed to examine how the phonological loop influences reading ability and processing in Chinese children with developmental dyslexia (DD).Methods: This study included 30 children with DD and 37 children without DD. Two types of articles (i.e., scenery prose and narrative story) and two conditions (under the conditions of articulatory-suppression and silent reading) were applied. An eye-link II High-Speed Eye Tracker was used to track a series of eye-movement parameters. The data were analyzed by the linear Mixed-Effects model.Results: Compared with children without DD, Children with DD had lower reading achievement (RA), frequency of saccades (FS) and frequency of fixations (FF), longer reading time (RT) and average fixation duration (AFD), slower reading speed (RS), shorter average saccade amplitude (ASA) and fixation distance (FD), more number of fixations (NF), and number of saccades (NS). There were significant interactions between participant group and articulatory suppression on RT and FD. We also observed interaction effects between article types and articulatory suppression on RA, AFD, ASA, and FS.Conclusion: Children DD exhibit abnormal phonological loop and eye movements while reading. The role of articulatory suppression on reading varies with the presentation of DD and the article type.

Memory for actions in Chinese children with developmental dyslexia

2019 ◽  
Vol 21 (3) ◽  
pp. 427-433
Author(s):  
Guangzheng Li ◽  
Qingling Yang ◽  
Jing Yang ◽  
Huiyue Liu ◽  
Linxiang Jia
Keyword(s):  
Developmental Dyslexia ◽  
Chinese Children
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