scholarly journals No links between genetic variation and developing theory of mind: A preregistered replication attempt of candidate gene studies

2021 ◽  
Author(s):  
Timm Opitz ◽  
Tobias Schuwerk ◽  
Markus Paulus ◽  
Daniela Kloo ◽  
Christopher Osterhaus ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Theory Of Mind ◽  
Candidate Gene ◽  
Candidate Gene Studies

scholarly journals Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results

2011 ◽  
Vol 42 (3) ◽  
pp. 607-616 ◽  
Author(s):  
A. L. Collins ◽  
Y. Kim ◽  
P. Sklar ◽  
M. C. O'Donovan ◽  
P. F. Sullivan ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Candidate Gene ◽  
Candidate Genes ◽  
Association Studies ◽  
Human Diseases ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Common Genetic Variation ◽  
Genome Wide ◽  
Candidate Gene Studies

BackgroundCandidate gene studies have been a key approach to the genetics of schizophrenia (SCZ). However, the results of these studies are confusing and no genes have been unequivocally implicated. The hypothesis-driven candidate gene literature can be appraised by comparison with the results of genome-wide association studies (GWAS).MethodWe describe the characteristics of hypothesis-driven candidate gene studies from the SZGene database, and use pathway analysis to compare hypothesis-driven candidate genes with GWAS results from the International Schizophrenia Consortium (ISC).ResultsSZGene contained 732 autosomal genes evaluated in 1374 studies. These genes had poor statistical power to detect genetic effects typical for human diseases, assessed only 3.7% of genes in the genome, and had low marker densities per gene. Most genes were assessed once or twice (76.9%), providing minimal ability to evaluate consensus across studies. The ISC studies had 89% power to detect a genetic effect typical for common human diseases and assessed 79% of known autosomal common genetic variation. Pathway analyses did not reveal enrichment of smaller ISCpvalues in hypothesis-driven candidate genes, nor did a comprehensive evaluation of meta-hypotheses driving candidate gene selection (SCZ as a disease of the synapse or neurodevelopment). The most studied hypothesis-driven candidate genes (COMT,DRD3,DRD2,HTR2A,NRG1,BDNF,DTNBP1andSLC6A4) had no notable ISC results.ConclusionsWe did not find support for the idea that the hypothesis-driven candidate genes studied in the literature are enriched for the common genetic variation involved in the etiology of SCZ. Larger samples are required to evaluate this conclusion definitively.

Candidate gene studies of bipolar disorder

2001 ◽  
Vol 33 (4) ◽  
pp. 248-256 ◽  
Author(s):  
Ian Jones ◽  
Nick Craddock
Keyword(s):  
Bipolar Disorder ◽  
Candidate Gene ◽  
Candidate Gene Studies

Candidate gene studies of fibromyalgia: a systematic review and meta-analysis

2010 ◽  
Vol 32 (2) ◽  
pp. 417-426 ◽  
Author(s):  
Young Ho Lee ◽  
Sung Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Systematic Review ◽  
Candidate Gene ◽  
Meta Analysis ◽  
Candidate Gene Studies

scholarly journals Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis

2011 ◽  
Vol 728 (1-2) ◽  
pp. 67-79 ◽  
Author(s):  
Kshitij Srivastava ◽  
Anvesha Srivastava ◽  
Kiran Lata Sharma ◽  
Balraj Mittal
Keyword(s):  
Systematic Review ◽  
Candidate Gene ◽  
Gallbladder Cancer ◽  
Meta Analysis ◽  
Candidate Gene Studies

scholarly journals The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chenxing Liu ◽  
Tetsufumi Kanazawa ◽  
Ye Tian ◽  
Suriati Mohamed Saini ◽  
Serafino Mancuso ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Candidate Gene Studies

scholarly journals Linkage and candidate gene studies of autism spectrum disorders in European populations

2010 ◽  
Vol 18 (9) ◽  
pp. 1013-1019 ◽  
Author(s):  
Richard Holt ◽  
◽  
Gabrielle Barnby ◽  
Elena Maestrini ◽  
Elena Bacchelli ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Candidate Gene ◽  
Autism Spectrum ◽  
Candidate Gene Studies ◽  
Spectrum Disorders ◽  
European Populations

scholarly journals Candidate gene studies of diabetic retinopathy in human

2016 ◽  
Vol 43 (12) ◽  
pp. 1327-1345 ◽  
Author(s):  
Petra Priščáková ◽  
Gabriel Minárik ◽  
Vanda Repiská
Keyword(s):  
Diabetic Retinopathy ◽  
Candidate Gene ◽  
Candidate Gene Studies
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