scholarly journals Usefulness of contrast‐enhanced endoscopic ultrasonography for the treatment of ethanol reinjection in patient with small pancreatic neuroendocrine neoplasm

2021 ◽  
Author(s):  
Kazuyuki Matsumoto ◽  
Hironari Kato ◽  
Hiroyuki Okada
Keyword(s):  
Endoscopic Ultrasonography ◽  
Neuroendocrine Neoplasm ◽  
Contrast Enhanced ◽  
Pancreatic Neuroendocrine Neoplasm

scholarly journals Study protocol for endoscopic ultrasonography-guided ethanol injection therapy for patients with pancreatic neuroendocrine neoplasm: a multicentre prospective study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046505
Author(s):  
Kazuyuki Matsumoto ◽  
Hironari Kato ◽  
Masayuki Kitano ◽  
Kazuo Hara ◽  
Masaki Kuwatani ◽  
...  
Keyword(s):  
Adverse Events ◽  
Prospective Study ◽  
Endoscopic Ultrasonography ◽  
Injection Therapy ◽  
Neuroendocrine Neoplasm ◽  
Efficacy And Safety ◽  
Ethanol Injection ◽  
Pancreatic Neuroendocrine Neoplasm ◽  
Ethanol Injection Therapy ◽  
Multicentre Prospective Study

IntroductionThe management of small pancreatic neuroendocrine neoplasms (PNENs) remains controversial. The standard treatment for PNENs is surgical resection; however, invasiveness of surgical procedure remains higher and the incidence of postoperative adverse events is still high. Recently, the efficacy and safety of endoscopic ultrasonography (EUS)-guided ethanol injection for small PNENs has been preliminarily demonstrated. Thus, a multicentre prospective study is being conducted to evaluate the efficacy and safety of EUS-guided ethanol injection therapy for small PNENs.Methods and analysisThe major eligibility criteria are the presence of pathologically diagnosed grade (G) 1 tumour, a tumour size of ≤15 mm and non-functional PNEN or insulinoma. For treatment, we will use a 25-gauge needle and pure ethanol. Contrast-enhanced CT (CE-CT) will be performed on postoperative day 3–5, and if enhanced areas of the tumour are still apparent, an additional session is scheduled during the same hospitalisation period. We set the total amount of ethanol per session to 2 mL. To evaluate the efficacy and safety, CE-CT will be performed at 1 and 6 months after treatment. The primary endpoint is the percentage of subjects who achieved all of the following evaluated points. Efficacy will be evaluated based on the achievement of complete ablation (defined as no enhanced area within the tumour on CE-CT) at 1 and 6 months. Safety will be evaluated based on the avoidance of severe adverse events within 1 month after treatment, continuing severe pancreatic fistula at 1 month after treatment and the incidence and/or exacerbation of diabetes mellitus at 6 months after treatment.Ethics and disseminationThis protocol has been approved by Okayama University Certified Review Board (approval number. CRB19-007). The results will be submitted to peer-reviewed journals and will be presented at international conferences.Trial registration numberjRCTs061200016.

Contrast-enhanced ultrasonography and endoscopic ultrasonography in the diagnosis of pancreatic disorders

Choonpa Igaku ◽  
2014 ◽  
Vol 41 (3) ◽  
pp. 339-351
Author(s):  
Yoshiki HIROOKA ◽  
Akihiro ITOH ◽  
Hiroki KAWASHIMA ◽  
Eizaburo ONO ◽  
Hidemi GOTO
Keyword(s):  
Endoscopic Ultrasonography ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Pancreatic Disorders

scholarly journals The Value of Alkaline Phosphatase-to-Albumin Ratio in Detecting Synchronous Metastases and Predicting Postoperative Relapses among Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Wentao Zhou ◽  
Yuan Fang ◽  
Xu Han ◽  
Tiantao Kuang ◽  
Xuefeng Xu ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Distant Metastasis ◽  
Vascular Invasion ◽  
Biological Behavior ◽  
Neuroendocrine Neoplasm ◽  
Albumin Ratio ◽  
Pancreatic Neuroendocrine Neoplasm ◽  
Synchronous Metastases ◽  
Well Differentiated ◽  
Synchronous Distant Metastasis

Backgrounds. Pancreatic neuroendocrine neoplasm (pNEN) is a highly heterogeneous entity, presenting widely varied biological behavior as well as long-term prognosis. Reliable biomarkers are urgently needed to make risk stratifications for pNEN patients, which could be beneficial to the development of individualized therapeutic strategy in the clinical practice. Here, we aimed to evaluate the predictive and prognostic roles of serum alkaline phosphatase-to-albumin ratio (APAR) in well-differentiated pNEN patients. Methods. We retrospectively analyzed the pathologically confirmed grade 1/2 pNEN patients, who were originally treated in our hospital from February 2008 to April 2018. Univariate and multivariate analyses were performed to assess the value of APAR in detecting synchronous metastases and predicting relapses following curative resections. Results. A total of 170 eligible cases were included into analysis. Logistic univariate analysis indicated APAR (P=0.002) was significantly associated with synchronous distant metastasis among well-differentiated pNEN patients, which was further demonstrated to be an independent risk factor by multivariate analysis (odds ratio 8.127, 95% confidence interval (CI) 2.105–31.372, P=0.002). For the prognostic value, APAR (P=0.007) was statistically associated with recurrence-free survival (RFS) in nonmetastatic resected pNEN patients, but it was not an independent predictor. Further subgroup analysis showed that APAR was independently related to RFS in patients with no nerve (hazard ratio (HR) 7.685, 95% CI 1.433–41.209, P=0.017) or vascular invasion (HR 4.789, 95% CI 1.241–18.473, P=0.023), respectively. Conclusion. APAR may work as a convenient pretreatment marker to detect synchronous distant metastasis for well-differentiated pNEN patients and predict recurrences for curatively resected cases without nerve or vascular invasion. However, these findings should be further verified in prospectively well-designed studies.

scholarly journals Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma

2016 ◽  
Vol 22 (3) ◽  
pp. 198 ◽  
Author(s):  
Toshiyuki Uekitani ◽  
Seiji Kaino ◽  
Hirofumi Harima ◽  
Shigeyuki Suenaga ◽  
Manabu Sen-yo ◽  
...  
Keyword(s):  
Endoscopic Ultrasonography ◽  
Ductal Carcinoma ◽  
Pancreatic Ductal Carcinoma ◽  
Contrast Enhanced

scholarly journals Duodenal Metastasis from a Pancreatic Neuroendocrine Neoplasm

2020 ◽  
Vol 59 (24) ◽  
pp. 3245-3246
Author(s):  
Akinobu Koiwai ◽  
Morihisa Hirota ◽  
Kennichi Satoh
Keyword(s):  
Neuroendocrine Neoplasm ◽  
Pancreatic Neuroendocrine Neoplasm ◽  
Duodenal Metastasis
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