scholarly journals Use of curcumin solution for probe‐based confocal laser endomicroscopy of squamous cell carcinoma of the esophagus

2018 ◽  
Vol 31 (1) ◽  
pp. 105-105 ◽  
Author(s):  
Hiroki Kurumi ◽  
Kouichi Nonaka ◽  
Shomei Ryozawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Carcinoma Of The Esophagus

Confocal Laser Endomicroscopy for In Vivo Diagnosis of Early Squamous Cell Carcinoma in the Esophagus

2007 ◽  
Vol 65 (5) ◽  
pp. AB346 ◽  
Author(s):  
Oliver Pech ◽  
Thomas Rabenstein ◽  
Hendrik Manner ◽  
Maria C. Petrone ◽  
Juergen Pohl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Early Squamous Cell Carcinoma ◽  
In Vivo Diagnosis

Confocal laser endomicroscopy for superficial esophageal squamous cell carcinoma

Endoscopy ◽  
2009 ◽  
Vol 41 (02) ◽  
pp. 99-106 ◽  
Author(s):  
H. Liu ◽  
Y. Li ◽  
T. Yu ◽  
Y. Zhao ◽  
J. Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

scholarly journals Intraoperative free margins assessment of oropharyngeal squamous cell carcinoma with confocal laser endomicroscopy: a pilot study

2021 ◽  
Author(s):  
Matti Sievert ◽  
Florian Stelzle ◽  
Marc Aubreville ◽  
Sarina K. Mueller ◽  
Markus Eckstein ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Pilot Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Resection ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Optical Biopsy ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Uniform Size

Abstract Purpose This pilot study aimed to assess the feasibility of intraoperative assessment of safe margins with confocal laser endomicroscopy (CLE) during oropharyngeal squamous cell carcinoma (OPSCC) surgery. Methods We included five consecutive patients confirmed OPSCC and planned tumor resection in September and October 2020. Healthy appearing mucosa in the marginal zone, and the tumor margin, were examined with CLE and biopsy during tumor resection. A total of 12,809 CLE frames were correlated with the gold standard of hematoxylin and eosin staining. Three head and neck surgeons and one pathologist were asked to identify carcinoma in a sample of 169 representative images, blinded to the histological results. Results Healthy mucosa showed epithelium with uniform size and shape with distinct cytoplasmic membranes and regular vessel architecture. CLE optical biopsy of OPSCC demonstrated a disorganized arrangement of variable cellular morphology. We calculated an accuracy, sensitivity, specificity, PPV, and NPV of 86%, 90%, 79%, 88%, and 82%, respectively, with inter-rater reliability and κ-value of 0.60. Conclusion CLE can be easily integrated into the intraoperative setting, generate real-time, in-vivo microscopic images of the oropharynx for evaluation and demarcation of cancer. It can eventually contribute to a less radical approach by enabling a more precise evaluation of the cancer margin.

Confocal Laser Endomicroscopy for In Vivo Diagnosis of Early Squamous Cell Carcinoma in the Esophagus

2008 ◽  
Vol 6 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Oliver Pech ◽  
Thomas Rabenstein ◽  
Hendrik Manner ◽  
Maria C. Petrone ◽  
Jürgen Pohl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Early Squamous Cell Carcinoma ◽  
In Vivo Diagnosis

scholarly journals Impact of intraepithelial capillary loops and atypical vessels in confocal laser endomicroscopy for the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

2021 ◽  
Author(s):  
Matti Sievert ◽  
Markus Eckstein ◽  
Konstantinos Mantsopoulos ◽  
Sarina K. Mueller ◽  
Florian Stelzle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Blood Vessels ◽  
Squamous Cell ◽  
Vessel Diameter ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Significant Feature ◽  
Healthy Mucosa

Abstract Purpose Confocal laser endomicroscopy (CLE) allows surface imaging of the laryngeal and pharyngeal mucosa in vivo at a thousand-fold magnification. This study aims to compare irregular blood vessels and intraepithelial capillary loops in healthy mucosa and squamous cell carcinoma (SCC) via CLE. Materials and methods We included ten patients with confirmed SCC and planned total laryngectomy in this study between March 2020 and February 2021. CLE images of these patients were collected and compared with the corresponding histology in hematoxylin and eosin staining. We analyzed the characteristic endomicroscopic patterns of blood vessels and intraepithelial capillary loops for the diagnosis of SCC. Results In a total of 54 sequences, we identified 243 blood vessels which were analyzed regarding structure, diameter, and Fluorescein leakage, confirming that irregular, corkscrew-like vessels (24.4% vs. 1.3%; P < .001), dilated intraepithelial capillary loops (90.8% vs. 28.7%; P < .001), and increased capillary leakage (40.7% vs. 2.5%; P < .001), are significantly more frequently detected in SCC compared to the healthy epithelium. We defined a vessel diameter of 30 μm in capillary loops as a cut-off value, obtaining a sensitivity, specificity, PPV, and NPV and accuracy of 90.6%, 71.3%, 57.4%, 94.7%, and 77.1%, respectively, for the detection of malignancy based solely on capillary architecture. Conclusion Capillaries within malignant lesions are fundamentally different from those in healthy mucosa regions. The capillary architecture is a significant feature aiding the identification of malignant mucosa areas during in-vivo, real-time CLE examination.

p53 Overexpression in squamous cell carcinoma of the esophagus

1997 ◽  
Vol 4 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Paul L. Baron ◽  
Christopher E. Gates ◽  
Carolyn E. Reed ◽  
Roberta L. D. Dikeman ◽  
Jay J. Drosieko ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Overexpression ◽  
Carcinoma Of The Esophagus

Tu1673 Usefulness of Magnified Endoscopy With NBI for Diagnosing the Depth of Invasion of Squamous Cell Carcinoma of the Esophagus

2012 ◽  
Vol 75 (4) ◽  
pp. AB484
Author(s):  
Toshiro Iizuka ◽  
Daisuke Kikuchi ◽  
Akihiro Yamada ◽  
Osamu Ogawa ◽  
Masanori Nakamura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Depth Of Invasion ◽  
Carcinoma Of The Esophagus ◽  
Magnified Endoscopy
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