Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium

2016 ◽  
Vol 28 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Waku Hatta ◽  
Kaname Uno ◽  
Tomoyuki Koike ◽  
Nobuyuki Ara ◽  
Naoki Asano ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Squamous Epithelium ◽  
Optical Coherence ◽  
Barrett’S Mucosa ◽  
Barrett's Mucosa

scholarly journals Contrast of nuclei in stratified squamous epithelium in optical coherence tomography images at 800 nm

2019 ◽  
Vol 12 (9) ◽  
Author(s):  
Si Chen ◽  
Xinyu Liu ◽  
Nanshuo Wang ◽  
Qianshan Ding ◽  
Xianghong Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Squamous Epithelium ◽  
Optical Coherence ◽  
Stratified Squamous Epithelium

Dysregulated expression of minichromosome maintenance proteins 2 and 5 in esophageal squamous epithelium and Barrett's mucosa

2000 ◽  
Vol 118 (4) ◽  
pp. A37
Author(s):  
Lisa J. Neilson ◽  
Robert C. Stuart ◽  
Kai Stoeber ◽  
Gareth Williams ◽  
James J. Going
Keyword(s):  
Squamous Epithelium ◽  
Minichromosome Maintenance ◽  
Barrett’S Mucosa ◽  
Barrett's Mucosa

Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture

2007 ◽  
Vol 293 (1) ◽  
pp. G45-G53 ◽  
Author(s):  
Sabine Roman ◽  
Aurélia Pétré ◽  
Amélie Thépot ◽  
Agnès Hautefeuille ◽  
Jean-Yves Scoazec ◽  
...  
Keyword(s):  
Stress Responses ◽  
Squamous Epithelium ◽  
Degradation Mechanism ◽  
P53 Protein ◽  
Time Frame ◽  
Lower Esophagus ◽  
Barrett’S Mucosa ◽  
Cox 2 ◽  
Barrett's Mucosa ◽  
Glandular Metaplasia

p63 is a member of the p53 protein family that regulates differentiation and morphogenesis in epithelial tissues and is required for the formation of squamous epithelia. Barrett's mucosa is a glandular metaplasia of the squamous epithelium that develops in the lower esophagus in the context of chronic, gastroesophageal reflux and is considered as a precursor for adenocarcinoma. Normal or squamous cancer esophageal cells were exposed to deoxycholic acid (DCA, 50, 100, or 200 μM) and chenodeoxycholic and taurochenodeoxycholic acid at pH 5. p63 and cyclooxygenase-2 (COX-2) expressions were studied by Western blot and RT-PCR. DCA exposure at pH 5 led to a spectacular decrease in the levels of all isoforms of the p63 proteins. This decrease was observed within minutes of exposure, with a synergistic effect between DCA and acid. Within the same time frame, levels of p63 mRNA were relatively unaffected, whereas levels of COX-2, a marker of stress responses often induced in Barrett's mucosa, were increased. Similar results were obtained with chenodeoxycholic acid but not its taurine conjugate at pH 5. Proteasome inhibition by lactacystin or MG-132 partially blocked the decrease in p63, suggesting a posttranslational degradation mechanism. These results show that combined exposure to bile salt and acid downregulates a critical regulator of squamous differentiation, providing a mechanism to explain the replacement of squamous epithelium by a glandular metaplasia upon exposure of the lower esophagus to gastric reflux.

1086: Cystoscopic Optical Coherence Tomography in Diagnosis and Management of Clinical Bladder Tumors

2007 ◽  
Vol 177 (4S) ◽  
pp. 358-359 ◽  
Author(s):  
Christopher S. Lee ◽  
Alek Mishail ◽  
Jason M. Kim ◽  
Alexander Kirshenbaum ◽  
Howard L. Adler ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Tumors ◽  
Diagnosis And Management

1227: Optical Coherence Tomography-Guided Surgery of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Guided Surgery

258: Diagnosis and Intraoperative Staging of Bladder Disease by in-vivo Optical Coherence Tomography (OCT)

2004 ◽  
Vol 171 (4S) ◽  
pp. 68-68 ◽  
Author(s):  
Markus D. Sachs ◽  
Dmitry Daniltchenko ◽  
Eva Lankenau ◽  
Frank Koenig ◽  
Gerion Huettmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Bladder Disease
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