Topical calcineurin inhibitors and risk of lymphoma: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Po‐Chien Wu ◽  
I‐Hsin Huang ◽  
Che‐Wei Liu ◽  
Yu‐Chen Huang
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Calcineurin Inhibitors ◽  
Topical Calcineurin Inhibitors

Topical calcineurin inhibitors in the treatment of oral lichen planus: a systematic review and meta‐analysis

2019 ◽  
Vol 181 (6) ◽  
pp. 1166-1176 ◽  
Author(s):  
S.‐L. Sun ◽  
J.‐J. Liu ◽  
B. Zhong ◽  
J.‐K. Wang ◽  
X. Jin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Calcineurin Inhibitors ◽  
Topical Calcineurin Inhibitors ◽  
Oral Lichen

Topical calcineurin inhibitors in atopic dermatitis: A systematic review and meta-analysis

2009 ◽  
Vol 54 (2) ◽  
pp. 76-87 ◽  
Author(s):  
Mohammad Maged. Y. El-Batawy ◽  
Manal A.-W. Bosseila ◽  
Heba M. Mashaly ◽  
Vanessa Suzan G.A. Hafez
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Meta Analysis ◽  
Calcineurin Inhibitors ◽  
Topical Calcineurin Inhibitors

Mammalian Target of Rapamycin Inhibitors Vs Calcineurin Inhibitors in Chronic Graft Rejection After Lung Transplantation: A Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Andressa Rodrigues de Souza ◽  
Thulssa Auxiliadora Gomes Medeiros dos Santos ◽  
Camila Bomfim Von Jakitsch ◽  
Ana Lúcia Gargione Galvão de Sant'Anna ◽  
João Carlos Marchiori de Claudio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Transplantation ◽  
Graft Rejection ◽  
Meta Analysis ◽  
Mammalian Target Of Rapamycin ◽  
Calcineurin Inhibitors ◽  
Target Of Rapamycin

scholarly journals EFFICACY OF TACROLIMUS FOR INDUCTION OF REMISSION IN PATIENTS WITH MODERATE-TO-SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2017 ◽  
Vol 54 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Juan LASA ◽  
Pablo OLIVERA
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Clinical Response ◽  
Clinical Efficacy ◽  
Lower Risk ◽  
Meta Analysis ◽  
Calcineurin Inhibitors ◽  
Cochrane Library ◽  
Severe Ulcerative Colitis ◽  
Risk Of Failure

ABSTRACT BACKGROUND There is evidence that shows that calcineurin inhibitors may be useful for the treatment of severe ulcerative colitis. However, evidence regarding the efficacy of tacrolimus for remission induction in this setting is scarce. OBJECTIVE To develop a systematic review on the existing evidence regarding the clinical efficacy of tacrolimus for the induction of remission in patients with moderate-to-severe ulcerative colitis. METHODS A literature search was undertaken from 1966 to August 2016 using MEDLINE, Embase, LILACS and the Cochrane Library. The following MeSH terms were used: “Inflammatory Bowel Diseases” or “Ulcerative Colitis” and “Calcineurin Inhibitors” or “Tacrolimus” or “FK506”. Studies performed in adult ulcerative colitis patients that evaluated the clinical efficacy of tacrolimus for the induction of remission were considered for revision. A meta-analysis was performed with those included studies that were also placebo-controlled and randomized. Clinical response as well as clinical remission and mucosal healing were evaluated. RESULTS Overall, 755 references were identified, from which 22 studies were finally included. Only two of them were randomized, placebo-controlled trials. A total of 172 patients were evaluated. A significantly lower risk of failure in clinical response was found for tacrolimus versus placebo [RR 0.58 (0.45-0.73)]; moreover, a lower risk of failure in the induction of remission was also found versus placebo [RR 0.91 (0.82-1)]. CONCLUSION Tacrolimus seems to be a valid therapeutic alternative for the induction of remission in patients with moderate-to-severe ulcerative colitis.

Sign in / Sign up

Export Citation Format

Share Document