Persisting maculopapular exanthema in a 78‐year‐old woman

2021 ◽  
Author(s):  
Elena Eber ◽  
Teresa Deinlein ◽  
Birger Kränke ◽  
Birgit Sadoghi
Keyword(s):  
Maculopapular Exanthema

Maculopapular exanthema from diacetyl-midecamycin (MOM)

Allergy ◽  
1998 ◽  
Vol 53 (10) ◽  
pp. 1004-1005 ◽  
Author(s):  
J. M. Borja ◽  
P. A. Galindo ◽  
F. Feo ◽  
E. Gomez ◽  
A. Lasanta
Keyword(s):  
Maculopapular Exanthema

Expression of the Tim3‐galectin‐9 axis is altered in drug‐induced maculopapular exanthema

Allergy ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 1769-1779 ◽  
Author(s):  
Ruben Fernandez‐Santamaría ◽  
Francisca Palomares ◽  
Maria Salas ◽  
Inmaculada Doña ◽  
Gador Bogas ◽  
...  
Keyword(s):  
Drug Induced ◽  
Maculopapular Exanthema

scholarly journals Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients

Neurology ◽  
2017 ◽  
Vol 90 (4) ◽  
pp. e332-e341 ◽  
Author(s):  
Mark McCormack ◽  
Hongsheng Gui ◽  
Andrés Ingason ◽  
Doug Speed ◽  
Galen E.B. Wright ◽  
...  
Keyword(s):  
Genome Wide Association Study ◽  
Alternative Pathway ◽  
Han Chinese ◽  
Factor H ◽  
Complement Factor H ◽  
Chinese Patients ◽  
Complement Factor ◽  
Genetic Associations ◽  
Genetic Predictors ◽  
Maculopapular Exanthema

ObjectiveTo characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs.MethodsWe conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed.ResultsWe report an association between a rare variant in the complement factor H–related 4 (CFHR4) gene and phenytoin-induced MPE in Europeans (p = 4.5 × 10–11; odds ratio [95% confidence interval] 7 [3.2–16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H (CFH) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients.ConclusionsThe identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H–related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients.

Up-regulation of CCL17, CCL22 and CCR4 in drug-induced maculopapular exanthema

2007 ◽  
Vol 37 (5) ◽  
pp. 704-713 ◽  
Author(s):  
B. Tapia ◽  
E. Morel ◽  
M.-Á. Martín-Díaz ◽  
R. Díaz ◽  
J. Alves-Ferreira ◽  
...  
Keyword(s):  
Drug Induced ◽  
Maculopapular Exanthema

scholarly journals Dress Syndrome - A Case Report

2016 ◽  
Vol 8 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Zorana Kremić ◽  
Željko P. Mijušković ◽  
Lidija Kandolf-Sekulović
Keyword(s):  
Supportive Therapy ◽  
Dress Syndrome ◽  
Drug Induced ◽  
Systemic Manifestations ◽  
Inflammatory Drugs ◽  
Hematological Abnormalities ◽  
Systemic Symptoms ◽  
Generalized Epilepsy ◽  
Maculopapular Exanthema ◽  
Induced Reaction

Abstract The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse drug-induced reaction that occurs most commonly after exposure to drugs, most frequently anticonvulsants, sulfa derivates, antidepressants, nonsteroidal anti-inflammatory drugs, and antimicrobials. We present a 61-year-old male, with a generalized maculopapular exanthema on the trunk, face, extremities, palms, soles, palate, and fever (38°C). His medical history was notable for generalized epilepsy, treated with carbamazepine during 1 month. The diagnosis of DRESS syndrome was confirmed by specific RegiSCAR criteria. In our case, skin eruptions were successfully treated with oral methylprednisolone, cephalexin, and topical corticosteroid ointment. In conclusion, although the mechanisms of this syndrome are not completely understood, numerous cases were reported in children and adults. This syndrome should be considered in every patient with skin eruption, fever, eosinophilia, liver and hematological abnormalities. Prompt recognition, supportive therapy and initiation of corticosteroids may prevent systemic manifestations.

scholarly journals Severe Maculopapular Exanthema Induced by Regorafenib: Successful Desensitization and Adaptation of a Dosage Regimen

2019 ◽  
Vol 29 (4) ◽  
pp. 300-302 ◽  
Author(s):  
I García-Gutiérrez ◽  
M Acevedo ◽  
P Tornero ◽  
A Matilla ◽  
L Márquez ◽  
...  
Keyword(s):  
Dosage Regimen ◽  
Maculopapular Exanthema

scholarly journals Incidental papillary thyroid cancer diagnosis in patient with adult-onset Still’s disease-like manifestations

Reumatismo ◽  
2019 ◽  
Vol 71 (1) ◽  
pp. 42-45 ◽  
Author(s):  
R. Tirri ◽  
D. Capocotta
Keyword(s):  
Thyroid Cancer ◽  
Psoriatic Arthritis ◽  
Papillary Thyroid Cancer ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Papillary Thyroid ◽  
History Of ◽  
Maculopapular Exanthema ◽  
Adult Onset Still's Disease

Adult onset Still’s disease (AOSD) is a systemic inflammatory disease characterized primarily by a triad consisting of daily fever, arthritis and maculopapular exanthema. The pathogenesis and etiology of AOSD are unknown and the diagnosis, which can be very challenging, is often made by exclusion. Here, we report a case of a 61-year-old woman with a history of mild psoriatic arthritis, fever, arthritis and maculopapular exanthema. Her initial laboratory tests showed neutrophilic leukocytosis, hypertransaminasemia, and markedly elevated levels of the erythrocyte sedimentation rate and C-reactive protein. With a presumptive diagnosis of AOSD, based on Yamaguchi criteria, the patient started an extensive diagnostic work-up to exclude other potential differential diagnoses. With fluorodeoxyglucose (FDG) positron-emission tomography, a thyroid nodule with moderate FDG uptakes was detected. The fine needle aspiration biopsy led to diagnosis of papillary thyroid cancer. The history of psoriatic arthritis, the patient’s age, and atypical features of the skin rash described as not concomitant with fever flares, suggested a diagnosis of paraneoplastic AOSD-like manifestations.

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