Implementing real-time prescription drug monitoring: Are we ready?

2014 ◽  
Vol 33 (5) ◽  
pp. 463-465 ◽  
Author(s):  
Suzanne Nielsen ◽  
Raimondo Bruno
Keyword(s):  
Prescription Drug ◽  
Real Time ◽  
Drug Monitoring

scholarly journals Constructing a Real-Time Prescription Drug Monitoring System

2016 ◽  
Vol 22 (3) ◽  
pp. 178 ◽  
Author(s):  
Young-Taek Park ◽  
Youn Tae Lee ◽  
Emmanuel C. Jo
Keyword(s):  
Prescription Drug ◽  
Real Time ◽  
Monitoring System ◽  
Drug Monitoring ◽  
Drug Monitoring System

scholarly journals Real-time access to prescription drug monitoring databases

2012 ◽  
Vol 184 (16) ◽  
pp. 1767-1768 ◽  
Author(s):  
B. Wilsey ◽  
H. Prasad
Keyword(s):  
Prescription Drug ◽  
Real Time ◽  
Drug Monitoring

scholarly journals Impact of prescription drug monitoring program mandate on postoperative opioid prescriptions in children

2021 ◽  
Author(s):  
Christina M. Theodorou ◽  
Jordan E. Jackson ◽  
Ganesh Rajasekar ◽  
Miriam Nuño ◽  
Kaeli J. Yamashiro ◽  
...  
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Prescription Drug ◽  
Drug Monitoring ◽  
Monitoring Program ◽  
Interrupted Time Series ◽  
Surgical Patients ◽  
Interrupted Time Series Analysis ◽  
Opioid Prescription ◽  
Series Analysis

Abstract Purpose Prescription drug monitoring programs (PDMPs) have been established to combat the opioid epidemic, but there is no data on their efficacy in children. We hypothesized that a statewide PDMP mandate would be associated with fewer opioid prescriptions in pediatric surgical patients. Methods Patients < 18 undergoing inguinal hernia repair, orchiopexy, orchiectomy, appendectomy, or cholecystectomy at a tertiary children’s hospital were included. The primary outcome, discharge opioid prescription, was compared for 10 months pre-PDMP (n = 158) to 10 months post-PDMP (n = 228). Interrupted time series analysis was performed to determine the effect of the PDMP on opioid prescribing. Results Over the 20-month study period, there was an overall decrease in the rate of opioid prescriptions per month (− 3.6% change, p < 0.001). On interrupted time series analysis, PDMP implementation was not associated with a significant decrease in the monthly rate of opioid prescriptions (1.27% change post-PDMP, p = 0.4). However, PDMP implementation was associated with a reduction in opioid prescriptions of greater than 5 days’ supply (− 2.7% per month, p = 0.03). Conclusion Opioid prescriptions declined in pediatric surgical patients over the study time period. State-wide PDMP implementation was associated with a reduction in postoperative opioid prescriptions of more than 5 days’ duration.

Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Susanne Weber ◽  
Sara Tombelli ◽  
Ambra Giannetti ◽  
Cosimo Trono ◽  
Mark O’Connell ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Real Time ◽  
Drug Monitoring ◽  
Time Course ◽  
Drug Dosage ◽  
Immunosuppressive Drug ◽  
Therapeutic Drug ◽  
Continuous Sampling ◽  
Real Time Analysis ◽  
Drug Concentrations

AbstractObjectivesTherapeutic drug monitoring (TDM) plays a crucial role in personalized medicine. It helps clinicians to tailor drug dosage for optimized therapy through understanding the underlying complex pharmacokinetics and pharmacodynamics. Conventional, non-continuous TDM fails to provide real-time information, which is particularly important for the initial phase of immunosuppressant therapy, e.g., with cyclosporine (CsA) and mycophenolic acid (MPA).MethodsWe analyzed the time course over 8 h of total and free of immunosuppressive drug (CsA and MPA) concentrations measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 16 kidney transplant patients. Besides repeated blood sampling, intravenous microdialysis was used for continuous sampling. Free drug concentrations were determined from ultracentrifuged EDTA-plasma (UC) and compared with the drug concentrations in the respective microdialysate (µD). µDs were additionally analyzed for free CsA using a novel immunosensor chip integrated into a fluorescence detection platform. The potential of microdialysis coupled with an optical immunosensor for the TDM of immunosuppressants was assessed.ResultsUsing LC-MS/MS, the free concentrations of CsA (fCsA) and MPA (fMPA) were detectable and the time courses of total and free CsA comparable. fCsA and fMPA and area-under-the-curves (AUCs) in µDs correlated well with those determined in UCs (r≥0.79 and r≥0.88, respectively). Moreover, fCsA in µDs measured with the immunosensor correlated clearly with those determined by LC-MS/MS (r=0.82).ConclusionsThe new microdialysis-supported immunosensor allows real-time analysis of immunosuppressants and tailor-made dosing according to the AUC concept. It readily lends itself to future applications as minimally invasive and continuous near-patient TDM.

A Review on Prescription Drug Monitoring Program

2021 ◽  
pp. 265-268
Author(s):  
Someshwar D. Mankar ◽  
Abhijit S. Navale ◽  
Suraj R. Kadam
Keyword(s):  
Systematic Review ◽  
Prescription Drug ◽  
Drug Monitoring ◽  
Monitoring Program ◽  
Opioid Abuse ◽  
Prescription Opioid ◽  
Prescription Drug Monitoring Program ◽  
Prescription Opioid Abuse

Nowadays Prescription Opioid Abuse has become a serious problem, to monitor and reduce Opioid Abuse most of countries developed Prescription Drug Monitoring Program (PDMP). Regarding to this we conduct a systematic review to understanding the PDMP impact in order to reduce Opioid Abuse and improving prescriber practices. This review can help to guide efforts to better response to the Opioid crises.

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